Familial Mediterranean fever

Common Name(s)

Familial Mediterranean fever

Familial Mediterranean fever (FMF) is an inherited condition characterized by episodes of painful inflammation of the abdominal lining (peritonitis),  lining surrounding the lungs (pleurisy), and joints (arthralgia and occasionally arthritis). These episodes are often accompanied by fever and sometimes a characteristic ankle rash. The first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. Between attacks, people often do not have any symptoms. Without treatment, FMF can lead to kidney failure due to a buildup of certain protein deposits (amyloidosis). FMF is usually inherited in an autosomal recessive fashion and is caused by mutations in the MEFV gene.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Familial Mediterranean fever" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

Last Updated: 24 Jul 2015

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Familial Mediterranean fever" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

http://www.autoinflammatory.org

Last Updated: 24 Jul 2015

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

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General Resources

Healthier Ever After (injection tips book & program)

This child-friendly book is for patients and their families to learn how to manage their injectable medications, and has a program to help children to discuss and make a plan of care, and goals with rewards to chart on a reusable white board page.

Updated 6 May 2015

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Arts and Literature

CAPS medical guidebook.

Medical guidebook about Cryopyrin-Associated Periodic syndromes (CAPS).

Updated 6 May 2015

Open Doc
 
 
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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Familial Mediterranean fever" returned 371 free, full-text research articles on human participants. First 3 results:

Malignant nephrosclerosis in a patient with familial Mediterranean fever.
 

Author(s): Masayuki Yamanouchi, Yoshifumi Ubara, Aya Imafuku, Masahiro Kawada, Mise Koki, Keiichi Sumida, Rikako Hiramatsu, Eiko Hasegawa, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenichi Ohashi, Takeshi Fujii, Masayuki Matsuda, Kenmei Takaichi

Journal: Intern. Med.. 2015 ;54(20):2643-6.

 

A 37-year-old man was admitted to our hospital for an evaluation of renal dysfunction and hypertension. The C-reactive protein level was 6.0 mg/dL, and the serum renin activity was extremely high. A renal biopsy showed malignant nephrosclerosis-like lesions with an onion skin pattern. ...

Last Updated: 15 Oct 2015

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Diffuse and multifocal nephrogenic adenoma with Familial Mediterranean Fever: a case report with molecular study.
 

Author(s): Noriyoshi Ishikawa, Chika Amano, Takeshi Taketani, Koji Kumori, Yuji Harada, Hisayuki Hiraiwa, Kayoko Itamura, Riruke Maruyama

Journal:

 

Nephrogenic adenoma, also referred to nephrogenic metaplasia, is a benign proliferative lesion of urothelium, usually associated with chronic physical stimuli or inflammation. Familial Mediterranean fever is an inherited autosomal recessive disease characterized by recurrent short ...

Last Updated: 2 Oct 2015

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Different disease subtypes with distinct clinical expression in familial Mediterranean fever: results of a cluster analysis.
 

Author(s): Servet Akar, Dilek Solmaz, Timucin Kasifoglu, Sule Yasar Bilge, Ismail Sari, Zeynep Zehra Gumus, Mehmet Tunca

Journal: Rheumatology (Oxford). 2016 Feb;55(2):343-6.

 

The aim of this study was to evaluate whether there are clinical subgroups that may have different prognoses among FMF patients.

Last Updated: 14 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Familial Mediterranean fever" returned 27 free, full-text review articles on human participants. First 3 results:

Update on Auto-Inflammatory Diseases and Familial Mediterranean Fever.
 

Author(s): Yackov Berkun, Eli M Eisenstein

Journal: Isr. Med. Assoc. J.. ;18(3-4):221-4.

 

Last Updated: 27 May 2016

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EULAR recommendations for the management of familial Mediterranean fever.
 

Author(s): Seza Ozen, Erkan Demirkaya, Burak Erer, Avi Livneh, Eldad Ben-Chetrit, Gabriella Giancane, Huri Ozdogan, Illana Abu, Marco Gattorno, Philip N Hawkins, Sezin Yuce, Tilmann Kallinich, Yelda Bilginer, Daniel Kastner, Loreto Carmona

Journal: Ann. Rheum. Dis.. 2016 Apr;75(4):644-51.

 

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease, but many rheumatologists are not well acquainted with its management. The objective of this report is to produce evidence-based recommendations to guide rheumatologists and other health professionals ...

Last Updated: 11 Mar 2016

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Familial Mediterranean Fever.
 

Author(s): Adem Kucuk, Ilknur Albayrak Gezer, Ramazan Ucar, Ali Yavuz Karahan

Journal: Acta Medica (Hradec Kralove). 2014 ;57(3):97-104.

 

Familial Mediterranean Fever is an autosomal recessive inherited disease with a course of autoinflammation, which is characterized by the episodes of fever and serositis. It affects the populations from Mediterranean basin. Genetic mutation of the disease is on MEFV gene located on ...

Last Updated: 4 Feb 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Familial Mediterranean Fever and Related Disorders: Genetics and Disease Characteristics
 

Status: Recruiting

Condition Summary: Familial Mediterranean Fever (FMF)

 

Last Updated: 17 Aug 2016

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Last Updated: 26 Dec 2013

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Magnetic Resonance (MR) Spectroscopy In Familial Mediterranean Fever (FMF) Patients
 

Status: Recruiting

Condition Summary: Familial Mediterranean Fever

 

Last Updated: 11 Apr 2008

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