Familial Mediterranean fever

Common Name(s)

Familial Mediterranean fever

Familial Mediterranean fever (FMF) is an inherited condition characterized by episodes of painful inflammation of the abdominal lining (peritonitis),  lining surrounding the lungs (pleurisy), and joints (arthralgia and occasionally arthritis). These episodes are often accompanied by fever and sometimes a characteristic ankle rash. The first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. Between attacks, people often do not have any symptoms. Without treatment, FMF can lead to kidney failure due to a buildup of certain protein deposits (amyloidosis). FMF is usually inherited in an autosomal recessive fashion and is caused by mutations in the MEFV gene.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Familial Mediterranean fever" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

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The NOMID Alliance

The NOMID Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases.

Last Updated: 16 Aug 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Familial Mediterranean fever" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

View Details
stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

View Details
The NOMID Alliance

The NOMID Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases.

http://www.nomidalliance.org

Last Updated: 16 Aug 2013

View Details

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Familial Mediterranean fever" returned 280 free, full-text research articles on human participants. First 3 results:

A novel insertion mutation identified in exon 10 of the MEFV gene associated with Familial Mediterranean Fever.
 

Author(s): Hasan Dogan, Fatih Akdemir, Sener Tasdemir, Omer Atis, Eda Diyarbakir, Rahsan Yildirim, Mucahit Emet, Mevlit Ikbal

Journal:

 

Familial Mediterranean Fever (FMF), characterized by recurrent fever and inflammation of serous membranes, is an autosomal recessive disease caused by mutations in the Mediterranean fever (MEFV) gene. Around 296 mutations have been reported to date.

Last Updated: 14 Jul 2014

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Familial Mediterranean fever: genetic update.
 

Author(s): Alessandra Soriano, Elon Pras

Journal: Isr. Med. Assoc. J.. 2014 May;16(5):274-6.

 

Last Updated: 1 Jul 2014

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Colchicine failure in familial Mediterranean fever and potential alternatives: embarking on the anakinra trial.
 

Author(s): Ilan Ben-Zvi, Avi Livneh

Journal: Isr. Med. Assoc. J.. 2014 May;16(5):271-3.

 

Familial Mediterranean fever (FMF) is a genetic auto-inflammatory disease characterized by spontaneous short attacks of fever, elevated acute-phase reactants, and serositis. Approximately 5%-10% of FMF patients do not respond to colchicine treatment and another 5% are intolerant to ...

Last Updated: 1 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Familial Mediterranean fever" returned 22 free, full-text review articles on human participants. First 3 results:

Treatment of familial Mediterranean fever: colchicine and beyond.
 

Author(s): Ahmet Güil

Journal: Isr. Med. Assoc. J.. 2014 May;16(5):281-4.

 

Last Updated: 1 Jul 2014

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Three family members with familial Mediterranean fever carrying the M694V mutation showed different clinical presentations.
 

Author(s): Sukran Erten, Cahide Erzurum, Alpaslan Altunoglu

Journal: Intern. Med.. 2012 ;51(13):1765-8.

 

Familial Mediterranean fever (FMF) is an inherited disease characterized by recurrent episodes of fever and serositis. FMF is caused by mutations in the MEFV gene that encodes pyrin/marenostrin. The 5 most frequent mutations are M694V, M694I, V726A, M680I and E148Q. Here, we reported ...

Last Updated: 13 Jul 2012

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[Clinical aspects of Familial Mediterranean fever].
 

Author(s): Kiyoshi Migita, Kazunaga Agematsu

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2011 ;34(5):355-60.

 

Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease characterized by recurrent and short duration (1-3 days) of fever, and serositis. Based on the nationwide survey of FMF in Japan, the estimated number of Japanese FMF patients is about three hundred. High ...

Last Updated: 1 Nov 2011

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean Fever
 

Status: Recruiting

Condition Summary: Familial Mediterranean Fever,

 

Last Updated: 3 Nov 2013

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Familial Mediterranean Fever and Related Disorders: Genetics and Disease Characteristics
 

Status: Recruiting

Condition Summary: Periodic Disease

 

Last Updated: 14 Mar 2014

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Last Updated: 26 Dec 2013

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