Fallot Tetralogy

Common Name(s)

Fallot Tetralogy

Tetralogy of Fallot is a complex congenital heart defect characterized by a large ventricular septal defect (hole between the right and left ventricles), pulmonary stenosis (narrowing of the valve and artery that connect the heart with the lungs), an overriding aorta (the aorta - the artery that carries oxygen-rich blood to the body - is shifted over the right ventricle and ventricular septal defect, instead of coming out only from the left ventricle), and right ventricular hypertrophy (the muscle of the right ventricle is thicker than usual). Tetralogy of Fallot causes low oxygen levels in the blood, which can lead to cyanosis (a bluish-purple color to the skin). The cause of this condition is unknown. Treatment involves surgery to repair the heart defects. Sometimes more than one surgery is needed.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fallot Tetralogy" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

Last Updated: 15 Mar 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fallot Tetralogy" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

http://www.savinglittlehearts.com

Last Updated: 15 Mar 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Fallot Tetralogy" returned 661 free, full-text research articles on human participants. First 3 results:

Immediate and Midterm Cardiac Remodeling After Surgical Pulmonary Valve Replacement in Adults With Repaired Tetralogy of Fallot: A Prospective Cardiovascular Magnetic Resonance and Clinical Study.
 

Author(s): Ee Ling Heng, Michael A Gatzoulis, Anselm Uebing, Babulal Sethia, Hideki Uemura, Gillian C Smith, Gerhard-Paul Diller, Karen P McCarthy, Siew Yen Ho, Wei Li, Piers Wright, Veronica Spadotto, Philip J Kilner, Paul Oldershaw, Dudley J Pennell, Darryl F Shore, Sonya V Babu-Narayan

Journal: Circulation. 2017 Oct;136(18):1703-1713.

 

Pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot provides symptomatic benefit and right ventricular (RV) volume reduction. However, data on the rate of ventricular structural and functional adaptation are scarce. We aimed to assess immediate and midterm ...

Last Updated: 31 Dec 1969

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Effect of Pregnancy on Ventricular and Aortic Dimensions in Repaired Tetralogy of Fallot.
 

Author(s): Matthew Cauldwell, Michael A Quail, Gillian S Smith, Ee Ling Heng, Sarah Ghonim, Anselm Uebing, Lorna Swan, Wei Li, Roshni R Patel, Dudley J Pennell, Philip J Steer, Mark R Johnson, Michael A Gatzoulis, Sonya V Babu-Narayan

Journal:

 

The aim was to assess whether cardiovascular adaptation to pregnancy in women with repaired tetralogy of Fallot (TOF) adversely affects hemodynamic stability, in particular with respect to right ventricular (RV) dilatation, pulmonary regurgitation, or aortic root dilatation.

Last Updated: 31 Dec 1969

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Microarray analysis reveals key genes and pathways in Tetralogy of Fallot.
 

Author(s): Yue-E He, Hui-Xian Qiu, Jian-Bing Jiang, Rong-Zhou Wu, Ru-Lian Xiang, Yuan-Hai Zhang

Journal: Mol Med Rep. 2017 Sep;16(3):2707-2713.

 

The aim of the present study was to identify key genes that may be involved in the pathogenesis of Tetralogy of Fallot (TOF) using bioinformatics methods. The GSE26125 microarray dataset, which includes cardiovascular tissue samples derived from 16 children with TOF and five healthy ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Fallot Tetralogy" returned 16 free, full-text review articles on human participants. First 3 results:

Ventricular arrhythmias and sudden death in tetralogy of Fallot.
 

Author(s): Philippe Maury, Frederic Sacher, Anne Rollin, Pierre Mondoly, Alexandre Duparc, Katja Zeppenfeld, Sebastien Hascoet,

Journal: Arch Cardiovasc Dis. 2017 May;110(5):354-362.

 

Malignant ventricular arrhythmias and sudden cardiac death may late happen in repaired tetralogy of Fallot, although probably less frequently than previously thought, especially with the advent of new surgical techniques/management. Ventricular tachycardias are caused by reentry around ...

Last Updated: 31 Dec 1969

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Tetralogy of Fallot: Preoperative assessment with MR and CT imaging.
 

Author(s): C Lapierre, J Dubois, F Rypens, M-J Raboisson, J Déry

Journal: Diagn Interv Imaging. 2016 May;97(5):531-41.

 

Tetralogy of Fallot has a broad anatomical spectrum. In mild forms of the condition the obstruction is only located in the right ventricular infundibulum, whereas in severe forms the pulmonary valve is atretic, the pulmonary arteries are absent and the lung is supplied by aorto-pulmonary ...

Last Updated: 31 Dec 1969

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Late postoperative prosthetic pulmonary valve endocarditis in a 13-year-old girl with repaired tetralogy of fallot.
 

Author(s): Michael C O'Brien, Kamal K Pourmoghadam, William M DeCampli

Journal:

 

Prosthetic pulmonary valve endocarditis has infrequently been described outside large cohort reviews, which have typically focused on infections of the left-sided heart valves. Hence, the pathogenesis, clinical presentation, and management principles of prosthetic pulmonary valve ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Predictive Factors of Right Ventricular Function Early After Repair of Tetralogy of Fallot
 

Status: Not yet recruiting

Condition Summary: Tetralogy of Fallot

 

Last Updated: 18 Mar 2018

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Right and Left Ventricle Remodeling Predictors After Pulmonary Valve Replacement in Patients With Repaired Tetralogy of Fallot
 

Status: Recruiting

Condition Summary: Tetralogy of Fallot With Pulmonary Stenosis

 

Last Updated: 8 Jul 2014

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Tetralogy of Fallot for Life
 

Status: Recruiting

Condition Summary: Tetralogy of Fallot; Congenital Heart Disease; Congenital Heart Defect

 

Last Updated: 20 Sep 2017

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