Fallot Tetralogy

Common Name(s)

Fallot Tetralogy

Tetralogy of Fallot is a complex congenital heart defect characterized by a large ventricular septal defect (hole between the right and left ventricles), pulmonary stenosis (narrowing of the valve and artery that connect the heart with the lungs), an overriding aorta (the aorta - the artery that carries oxygen-rich blood to the body - is shifted over the right ventricle and ventricular septal defect, instead of coming out only from the left ventricle), and right ventricular hypertrophy (the muscle of the right ventricle is thicker than usual). Tetralogy of Fallot causes low oxygen levels in the blood, which can lead to cyanosis (a bluish-purple color to the skin). The cause of this condition is unknown. Treatment involves surgery to repair the heart defects. Sometimes more than one surgery is needed.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fallot Tetralogy" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

Last Updated: 15 Mar 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fallot Tetralogy" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

http://www.savinglittlehearts.com

Last Updated: 15 Mar 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Fallot Tetralogy" returned 602 free, full-text research articles on human participants. First 3 results:

Usage of 3D models of tetralogy of Fallot for medical education: impact on learning congenital heart disease.
 

Author(s): Yue-Hin Loke, Ashraf S Harahsheh, Axel Krieger, Laura J Olivieri

Journal:

 

Congenital heart disease (CHD) is the most common human birth defect, and clinicians need to understand the anatomy to effectively care for patients with CHD. However, standard two-dimensional (2D) display methods do not adequately carry the critical spatial information to reflect ...

Last Updated: 12 Mar 2017

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Basic arterial blood gas biomarkers as a predictor of mortality in tetralogy of Fallot patients.
 

Author(s): Vandana Bhardwaj, Poonam Malhotra Kapoor, Kalpana Irpachi, Suruchi Ladha, Ujjwal Kumar Chowdhury

Journal: Ann Card Anaesth. ;20(1):67-71.

 

Serum lactate and base deficit have been shown to be a predictor of morbidity and mortality in critically ill patients. Poor preoperative oxygenation appears to be one of the significant factors that affects early mortality in tetralogy of Fallot (TOF). There is little published literature ...

Last Updated: 11 Jan 2017

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High CpG island methylation of p16 gene and loss of p16 protein expression associate with the development and progression of tetralogy of Fallot.
 

Author(s): Si-Ju Gao, Gui-Fang Zhang, Rong-Peng Zhang

Journal: J. Genet.. 2016 Dec;95(4):831-837.

 

We examined CpG island methylation in p16 gene and its effect on p16 protein expression in tetralogy of Fallot (ToF) patients to explore its potential implications in the development and progression of ToF. The study subjects consisted of 75 healthy controls and 63 ToF patients recruited ...

Last Updated: 20 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Fallot Tetralogy" returned 15 free, full-text review articles on human participants. First 3 results:

Late postoperative prosthetic pulmonary valve endocarditis in a 13-year-old girl with repaired tetralogy of fallot.
 

Author(s): Michael C O'Brien, Kamal K Pourmoghadam, William M DeCampli

Journal:

 

Prosthetic pulmonary valve endocarditis has infrequently been described outside large cohort reviews, which have typically focused on infections of the left-sided heart valves. Hence, the pathogenesis, clinical presentation, and management principles of prosthetic pulmonary valve ...

Last Updated: 16 Jul 2015

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Tetralogy of fallot with dextrocardia and situs inversus in a 7-year-old boy.
 

Author(s): Michael Dilorenzo, Samuel Weinstein, Rajesh Shenoy

Journal: Tex Heart Inst J. 2013 ;40(4):481-3.

 

Tetralogy of Fallot is one of the most frequently diagnosed congenital cardiac abnormalities; however, its association with dextrocardia and situs inversus is reported only rarely. We report a case of these findings in a 7-year-old boy, describe the patient's postoperative course, ...

Last Updated: 1 Oct 2013

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Which is the best tissue valve used in the pulmonary position, late after previous repair of tetralogy of Fallot?
 

Author(s): Jonathan Raihan Abbas, J Andreas Hoschtitzky

Journal: Interact Cardiovasc Thorac Surg. 2013 Nov;17(5):854-60.

 

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: which is the best tissue valve for use in the pulmonary position, late after previous repair of tetralogy of Fallot? Altogether 141 papers were found using the reported ...

Last Updated: 23 Oct 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Right and Left Ventricle Remodeling Predictors After Pulmonary Valve Replacement in Patients With Repaired Tetralogy of Fallot
 

Status: Recruiting

Condition Summary: Tetralogy of Fallot With Pulmonary Stenosis

 

Last Updated: 8 Jul 2014

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Effects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of Fallot
 

Status: Recruiting

Condition Summary: Congenital Heart Defects; Tetralogy Of Fallot

 

Last Updated: 20 Apr 2016

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Tetralogy of Fallot for Life
 

Status: Recruiting

Condition Summary: Tetralogy of Fallot; Congenital Heart Disease; Congenital Heart Defect

 

Last Updated: 15 Nov 2016

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