Fallot Tetralogy

Common Name(s)

Fallot Tetralogy

Tetralogy of Fallot is a complex congenital heart defect characterized by a large ventricular septal defect (hole between the right and left ventricles), pulmonary stenosis (narrowing of the valve and artery that connect the heart with the lungs), an overriding aorta (the aorta - the artery that carries oxygen-rich blood to the body - is shifted over the right ventricle and ventricular septal defect, instead of coming out only from the left ventricle), and right ventricular hypertrophy (the muscle of the right ventricle is thicker than usual). Tetralogy of Fallot causes low oxygen levels in the blood, which can lead to cyanosis (a bluish-purple color to the skin). The cause of this condition is unknown. Treatment involves surgery to repair the heart defects. Sometimes more than one surgery is needed.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fallot Tetralogy" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

Last Updated: 15 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fallot Tetralogy" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

http://www.savinglittlehearts.com

Last Updated: 15 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Fallot Tetralogy" returned 446 free, full-text research articles on human participants. First 3 results:

Assessing the role of multiple pregnancies in the association between tetralogy of Fallot and assisted reproductive techniques: a path-analysis approach.
 

Author(s): Karim Tararbit, Nathalie Lelong, Lucile Houyel, Damien Bonnet, Fran├žois Goffinet, Babak Khoshnood,

Journal:

 

Assisted reproductive techniques (ART) are associated with a higher risk of tetralogy of Fallot (TOF) and multiple pregnancies may be associated with a higher risk of congenital anomalies. We assessed the extent to which the association between ART and risk of TOF may be mediated ...

Last Updated: 25 Feb 2014

Go To URL
Ultra high-resolution gene centric genomic structural analysis of a non-syndromic congenital heart defect, Tetralogy of Fallot.
 

Author(s): Douglas C Bittel, Xin-Gang Zhou, Nataliya Kibiryeva, Stephanie Fiedler, James E O'Brien, Jennifer Marshall, Shihui Yu, Hong-Yu Liu

Journal:

 

Tetralogy of Fallot (TOF) is one of the most common severe congenital heart malformations. Great progress has been made in identifying key genes that regulate heart development, yet approximately 70% of TOF cases are sporadic and nonsyndromic with no known genetic cause. We created ...

Last Updated: 5 Feb 2014

Go To URL
Association of promoter methylation statuses of congenital heart defect candidate genes with Tetralogy of Fallot.
 

Author(s): Wei Sheng, Yanyan Qian, Ping Zhang, Yao Wu, Huijun Wang, Xiaojing Ma, Long Chen, Duan Ma, Guoying Huang

Journal:

 

Although a lower methylation level of whole genome has been demonstrated in Tetralogy of Fallot (TOF) patients, little is known regarding changes in specific gene DNA methylation profiles and the possible associations with TOF. In current study, the promoter methylation statuses of ...

Last Updated: 7 Feb 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Fallot Tetralogy" returned 16 free, full-text review articles on human participants. First 3 results:

Is there a role for mechanical valve prostheses in pulmonary valve replacement late after tetralogy of Fallot repair?
 

Author(s): Jonathan Raihan Abbas, J Andreas Hoschtitzky

Journal: Interact Cardiovasc Thorac Surg. 2014 May;18(5):661-6.

 

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: What is the role of mechanical valve prostheses in pulmonary valve replacement late after tetralogy of Fallot (TOF) repair? Altogether more than 30 papers were found ...

Last Updated: 23 Apr 2014

Go To URL
Tetralogy of fallot with dextrocardia and situs inversus in a 7-year-old boy.
 

Author(s): Michael Dilorenzo, Samuel Weinstein, Rajesh Shenoy

Journal: Tex Heart Inst J. 2013 ;40(4):481-3.

 

Tetralogy of Fallot is one of the most frequently diagnosed congenital cardiac abnormalities; however, its association with dextrocardia and situs inversus is reported only rarely. We report a case of these findings in a 7-year-old boy, describe the patient's postoperative course, ...

Last Updated: 1 Oct 2013

Go To URL
Which is the best tissue valve used in the pulmonary position, late after previous repair of tetralogy of Fallot?
 

Author(s): Jonathan Raihan Abbas, J Andreas Hoschtitzky

Journal: Interact Cardiovasc Thorac Surg. 2013 Nov;17(5):854-60.

 

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: which is the best tissue valve for use in the pulmonary position, late after previous repair of tetralogy of Fallot? Altogether 141 papers were found using the reported ...

Last Updated: 23 Oct 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Right and Left Ventricle Remodeling Predictors After Pulmonary Valve Replacement in Patients With Repaired Tetralogy of Fallot
 

Status: Recruiting

Condition Summary: Tetralogy of Fallot With Pulmonary Stenosis

 

Last Updated: 8 Jul 2014

Go to URL
Tetralogy of Fallot Seed Grant
 

Status: Recruiting

Condition Summary: Pulmonary Regurgitation After Repair of Tetralogy of Fallot

 

Last Updated: 23 Jul 2008

Go to URL
Biomodel in Tetralogy of Fallot
 

Status: Recruiting

Condition Summary: Tetralogy of Fallot

 

Last Updated: 19 Dec 2005

Go to URL