Fallot Tetralogy

Common Name(s)

Fallot Tetralogy

Tetralogy of Fallot is a complex congenital heart defect characterized by a large ventricular septal defect (hole between the right and left ventricles), pulmonary stenosis (narrowing of the valve and artery that connect the heart with the lungs), an overriding aorta (the aorta - the artery that carries oxygen-rich blood to the body - is shifted over the right ventricle and ventricular septal defect, instead of coming out only from the left ventricle), and right ventricular hypertrophy (the muscle of the right ventricle is thicker than usual). Tetralogy of Fallot causes low oxygen levels in the blood, which can lead to cyanosis (a bluish-purple color to the skin). The cause of this condition is unknown. Treatment involves surgery to repair the heart defects. Sometimes more than one surgery is needed.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fallot Tetralogy" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

http://www.savinglittlehearts.com

Last Updated: 15 Mar 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fallot Tetralogy" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

http://www.savinglittlehearts.com

Last Updated: 15 Mar 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Fallot Tetralogy" returned 392 free, full-text research articles on human participants. First 3 results:

Contemporary predictors of death and sustained ventricular tachycardia in patients with repaired tetralogy of Fallot enrolled in the INDICATOR cohort.
 

Author(s): Anne Marie Valente, Kimberlee Gauvreau, Gabriele Egidy Assenza, Sonya V Babu-Narayan, Jenna Schreier, Michael A Gatzoulis, Maarten Groenink, Ryo Inuzuka, Philip J Kilner, Zeliha Koyak, Michael J Landzberg, Barbara Mulder, Andrew J Powell, Rachel Wald, Tal Geva

Journal: Heart. 2014 Feb;100(3):247-53.

 

Patients with repaired tetralogy of Fallot (TOF) experience increased rates of mortality and morbidity in adulthood. This study was designed to identify risk factors for death and ventricular tachycardia (VT) in a large contemporary cohort of patients with repaired TOF.

Last Updated: 6 Jan 2014

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[A 67-year-old men with not corrected tetralogy of Fallot].
 

Author(s): Kamila Ludwikowska, Karolina Konieczna, Anna Szarek, Dorota Kustrzycka-Kratochwil, Małgorzata Sukiennik-Kujawa, Elżbieta Kalicińska, Waldemar Banasiak, Piotr Ponikowski, Ewa A Jankowska

Journal: Kardiol Pol. 2013 ;71(8):861-3.

 

Tetralogy of Fallot is the most common cyanotic congenital heart disease. Total surgical correction of this defect during infancyallows for long-term survival in most of the patients. The long-term prognosis for untreated tetralogy of Fallot is poor and patients who have not undergone ...

Last Updated: 19 Sep 2013

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Low-frequency intermediate penetrance variants in the ROCK1 gene predispose to Tetralogy of Fallot.
 

Author(s): Julian Palomino Doza, Ana Topf, Jamie Bentham, Shoumo Bhattacharya, Catherine Cosgrove, J David Brook, Javier Granados-Riveron, Frances A Bu'Lock, John O'Sullivan, A Graham Stuart, Jonathan Parsons, Caroline Relton, Judith Goodship, Deborah J Henderson, Bernard Keavney

Journal:

 

Epidemiological studies indicate a substantial excess familial recurrence of non-syndromic Tetralogy of Fallot (TOF), implicating genetic factors that remain largely unknown. The Rho induced kinase 1 gene (ROCK1) is a key component of the planar cell polarity signalling pathway, which ...

Last Updated: 6 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Fallot Tetralogy" returned 13 free, full-text review articles on human participants. First 3 results:

Population-based review of tetralogy of Fallot with absent pulmonary valve: is prenatal diagnosis really associated with a poor prognosis?
 

Author(s): Y Mivelaz, K I Lim, C Templeton, A I Campbell, J E Potts, G G S Sandor

Journal: Ultrasound Obstet Gynecol. 2012 Nov;40(5):536-41.

 

Tetralogy of Fallot with absent pulmonary valve syndrome (TETAPV) is reported in obstetric literature to have an extremely poor prognosis. We sought to determine the clinical outcome associated with TETAPV and whether prenatal diagnosis confers a poor prognosis.

Last Updated: 21 Nov 2012

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[Patients after surgical repair of tetralogy of Fallot. Treatment or correction].
 

Author(s): Edward Malec, Katarzyna Malec, Katarzyna Januszewska

Journal: Kardiol Pol. 2012 ;70(1):75-9.

 

Last Updated: 23 Jan 2012

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Repaired tetralogy of Fallot: the roles of cardiovascular magnetic resonance in evaluating pathophysiology and for pulmonary valve replacement decision support.
 

Author(s): Tal Geva

Journal:

 

Surgical management of tetralogy of Fallot (TOF) results in anatomic and functional abnormalities in the majority of patients. Although right ventricular volume load due to severe pulmonary regurgitation can be tolerated for many years, there is now evidence that the compensatory ...

Last Updated: 10 Feb 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tetralogy of Fallot Seed Grant
 

Status: Recruiting

Condition Summary: Pulmonary Regurgitation After Repair of Tetralogy of Fallot

 

Last Updated: 23 Jul 2008

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Biomodel in Tetralogy of Fallot
 

Status: Recruiting

Condition Summary: Tetralogy of Fallot

 

Last Updated: 19 Dec 2005

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Effects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of Fallot
 

Status: Not yet recruiting

Condition Summary: Congenital Heart Defects; Tetralogy Of Fallot

 

Last Updated: 9 Sep 2013

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