Fallot Tetralogy

Common Name(s)

Fallot Tetralogy

Tetralogy of Fallot is a complex congenital heart defect characterized by a large ventricular septal defect (hole between the right and left ventricles), pulmonary stenosis (narrowing of the valve and artery that connect the heart with the lungs), an overriding aorta (the aorta - the artery that carries oxygen-rich blood to the body - is shifted over the right ventricle and ventricular septal defect, instead of coming out only from the left ventricle), and right ventricular hypertrophy (the muscle of the right ventricle is thicker than usual). Tetralogy of Fallot causes low oxygen levels in the blood, which can lead to cyanosis (a bluish-purple color to the skin). The cause of this condition is unknown. Treatment involves surgery to repair the heart defects. Sometimes more than one surgery is needed.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fallot Tetralogy" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

Last Updated: 15 Mar 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fallot Tetralogy" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

http://www.savinglittlehearts.com

Last Updated: 15 Mar 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Fallot Tetralogy" returned 440 free, full-text research articles on human participants. First 3 results:

DNA methylation status of NKX2-5, GATA4 and HAND1 in patients with tetralogy of fallot.
 

Author(s): Wei Sheng, Yanyan Qian, Huijun Wang, Xiaojing Ma, Ping Zhang, Lianwei Diao, Quan An, Long Chen, Duan Ma, Guoying Huang

Journal:

 

NKX2-5, GATA4 and HAND1 are essential for heart development, however, little is known regarding their epigenetic regulation in the pathogenesis of tetralogy of fallot (TOF).

Last Updated: 17 Jan 2014

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Contemporary predictors of death and sustained ventricular tachycardia in patients with repaired tetralogy of Fallot enrolled in the INDICATOR cohort.
 

Author(s): Anne Marie Valente, Kimberlee Gauvreau, Gabriele Egidy Assenza, Sonya V Babu-Narayan, Jenna Schreier, Michael A Gatzoulis, Maarten Groenink, Ryo Inuzuka, Philip J Kilner, Zeliha Koyak, Michael J Landzberg, Barbara Mulder, Andrew J Powell, Rachel Wald, Tal Geva

Journal: Heart. 2014 Feb;100(3):247-53.

 

Patients with repaired tetralogy of Fallot (TOF) experience increased rates of mortality and morbidity in adulthood. This study was designed to identify risk factors for death and ventricular tachycardia (VT) in a large contemporary cohort of patients with repaired TOF.

Last Updated: 6 Jan 2014

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[Histone acetylation and expression of acetylation-related enzymes in children with tetralogy of Fallot].
 

Author(s): Jun Xu, Yi-Xiang Lin, Ruo-Yi Gu, Hui-Jun Wang, Xiao-Jing Ma, Duan Ma, Guo-Ying Huang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2013 Oct;15(10):817-21.

 

To study the expression of histone acetyltransferases (HATs) and histone deacetylases (HDACs) in children with tetralogy of Fallot (TOF), and to investigate the role of histone acetylation and acetylation-related enzymes in the pathogenesis of TOF.

Last Updated: 17 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Fallot Tetralogy" returned 16 free, full-text review articles on human participants. First 3 results:

Tetralogy of fallot with dextrocardia and situs inversus in a 7-year-old boy.
 

Author(s): Michael Dilorenzo, Samuel Weinstein, Rajesh Shenoy

Journal: Tex Heart Inst J. 2013 ;40(4):481-3.

 

Tetralogy of Fallot is one of the most frequently diagnosed congenital cardiac abnormalities; however, its association with dextrocardia and situs inversus is reported only rarely. We report a case of these findings in a 7-year-old boy, describe the patient's postoperative course, ...

Last Updated: 1 Oct 2013

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Which is the best tissue valve used in the pulmonary position, late after previous repair of tetralogy of Fallot?
 

Author(s): Jonathan Raihan Abbas, J Andreas Hoschtitzky

Journal: Interact Cardiovasc Thorac Surg. 2013 Nov;17(5):854-60.

 

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: which is the best tissue valve for use in the pulmonary position, late after previous repair of tetralogy of Fallot? Altogether 141 papers were found using the reported ...

Last Updated: 23 Oct 2013

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Label-free quantitative proteomic analysis of right ventricular remodeling in infant Tetralogy of Fallot patients.
 

Author(s): Yu Xia, Haifa Hong, Lincai Ye, Yanlin Wang, Huiwen Chen, Jinfen Liu

Journal: J Proteomics. 2013 Jun;84():78-91.

 

Tetralogy of Fallot (TOF) results in chronic progressive right ventricular (RV) pressure overload and shunt hypoxemia. We investigated the global changes in the proteome of RV among infant patients with and without TOF to gain an insight into early RV remodeling. One hundred and thirty-six ...

Last Updated: 5 Jun 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tetralogy of Fallot Seed Grant
 

Status: Recruiting

Condition Summary: Pulmonary Regurgitation After Repair of Tetralogy of Fallot

 

Last Updated: 23 Jul 2008

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Right and Left Ventricle Remodeling Predictors After Pulmonary Valve Replacement in Patients With Repaired Tetralogy of Fallot
 

Status: Recruiting

Condition Summary: Tetralogy of Fallot With Pulmonary Stenosis

 

Last Updated: 8 Jul 2014

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Biomodel in Tetralogy of Fallot
 

Status: Recruiting

Condition Summary: Tetralogy of Fallot

 

Last Updated: 19 Dec 2005

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