Factor V Deficiency

Common Name(s)

Factor V Deficiency

Factor V deficiency is an inherited blood disorder that involves abnormal blood clotting (coagulation). This disorder is caused by the deficiency of a blood protein called factor V. The reduced amount of factor V leads to episodes of abnormal bleeding that range from mild to severe.  Factor V deficiency is inherited in an autosomal recessive manner, which means that both copies of the F5 gene in each cell have mutations.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Factor V Deficiency" for support, advocacy or research.

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The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

Last Updated: 3 Apr 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Factor V Deficiency" for support, advocacy or research.

Logo
The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

http://www.haemophilia.org.uk/

Last Updated: 3 Apr 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Factor V Deficiency" returned 66 free, full-text research articles on human participants. First 3 results:

Factor V Deficiency in Korean Patients: Clinical and Laboratory Features, Treatment, and Outcome.
 

Author(s): Young Hoon Park, Joo Han Lim, Hyeon Gyu Yi, Moon Hee Lee, Chul Soo Kim

Journal: J. Korean Med. Sci.. 2016 Feb;31(2):208-13.

 

Due to rarity of factor V (FV) deficiency, there have been only a few case reports in Korea. We retrospectively analysed the clinical-laboratory features of FV deficiency in 10 Korean patients. Between January 1987 and December 2013, 10 case reports published in a Korean journal or ...

Last Updated: 3 Feb 2016

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Platelets and platelet-derived factor Va confer hemostatic competence in complete factor V deficiency.
 

Author(s): Beth A Bouchard, John Chapin, Kathleen E Brummel-Ziedins, Peter Durda, Nigel S Key, Paula B Tracy

Journal: Blood. 2015 Jun;125(23):3647-50.

 

Whole genome sequencing of an individual completely devoid of plasma- and platelet-derived factor V (FV) identified 167 variants in his F5 gene including previously identified and damaging missense mutations at rs6027 and Leu90Ser. Because the administration of fresh frozen plasma ...

Last Updated: 5 Jun 2015

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Acquired factor V deficiency in a patient without evidence of a classical inhibitor.
 

Author(s): I R Sosa, P Ellery, A Mast, A T Neff, D Gailani

Journal: Haemophilia. 2014 Jan;20(1):e81-3.

 

Last Updated: 20 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Factor V Deficiency" returned 1 free, full-text review articles on human participants. First 3 results:

Factor V deficiency in a patient with rheumatoid arthritis.
 

Author(s): F Omata, Y Ichikawa, H Nozaki, H Nomoto, S Arimori

Journal: Jpn. J. Med.. ;30(2):157-60.

 

Factor V deficiency associated with rheumatoid arthritis was found in a 54-year-old woman. Hereditary factor V deficiency is very rare; only about 150 cases have been reported since its discovery in 1943. This appears to be the first case report of factor V deficiency associated with ...

Last Updated: 11 Sep 1991

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.