Exudative vitreoretinopathy 4

Common Name(s)

Exudative vitreoretinopathy 4

Familial exudative vitreoretinopathy (FEVR) is an inherited disorder characterized by the incomplete development of the retinal vasculature. Its clinical appearance varies considerably, even within families, with severely affected patients often registered as blind during infancy, whereas mildly affected patients with few or no visual problems may have such a small area of avascularity in their peripheral retina that it is visible only by fluorescein angiography. It is believed that this peripheral avascularity is the primary anomaly in FEVR and results from defective retinal angiogenesis. The sight-threatening features of the FEVR phenotype are considered secondary to retinal avascularity and develop because of the resulting retinal ischemia; they include the development of hyperpermeable blood vessels, neovascularization, vitreoretinal traction, retinal folds, and retinal detachments (summary by {3:Poulter et al., 2010}). For a discussion of genetic heterogeneity of familial exudative vitreoretinopathy, see EVR1 ({133780}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Exudative vitreoretinopathy 4" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Exudative vitreoretinopathy 4" returned 1 free, full-text research articles on human participants. First 3 results:

Frizzled 4 gene (FZD4) mutations in patients with familial exudative vitreoretinopathy with variable expressivity.
 

Author(s): H Kondo, H Hayashi, K Oshima, T Tahira, K Hayashi

Journal: Br J Ophthalmol. 2003 Oct;87(10):1291-5.

 

To search for mutations in the frizzled 4 (FZD4) gene in patients with familial exudative vitreoretinopathy (FEVR) and to delineate the defective gene associated clinical features.

Last Updated: 25 Sep 2003

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Exudative vitreoretinopathy 4" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.