Ewing's Sarcoma

Common Name(s)

Ewing's Sarcoma, Ewing Sarcoma, Ewings Sarcoma

Ewing's sarcoma is a malignant (cancerous) bone tumor that affects children. It can occur any time during childhood and young adulthood, but usually develops during puberty, when bones are growing rapidly. The tumor may arise anywhere in the body, usually in the long bones of the arms and legs, the pelvis, or the chest. It may also develop in the skull or the flat bones of the trunk. There are few symptoms. The most common is pain and occasionally swelling at the site of the tumor. Fever may also be present. The tumor often spreads (metastasis) to the lungs and other bones. The cause of Ewing's sarcoma is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ewing's Sarcoma" for support, advocacy or research.

Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ewing's Sarcoma" for support, advocacy or research.

Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ewing's Sarcoma" returned 246 free, full-text research articles on human participants. First 3 results:

Morphoproteomic profiling of the mammalian target of rapamycin (mTOR) signaling pathway in desmoplastic small round cell tumor (EWS/WT1), Ewing's sarcoma (EWS/FLI1) and Wilms' tumor(WT1).
 

Author(s): Vivek Subbiah, Robert E Brown, Yunyun Jiang, Jamie Buryanek, Andrea Hayes-Jordan, Razelle Kurzrock, Pete M Anderson

Journal:

 

Desmoplastic small round cell tumor (DSRCT) is a rare sarcoma in adolescents and young adults. The hallmark of this disease is a EWS-WT1 translocation resulting from apposition of the Ewing's sarcoma (EWS) gene with the Wilms' tumor (WT1) gene. We performed morphoproteomic profiling ...

Last Updated: 7 Aug 2013

Go To URL
The dual inhibitory effect of thiostrepton on FoxM1 and EWS/FLI1 provides a novel therapeutic option for Ewing's sarcoma.
 

Author(s): Aniruddha Sengupta, Mahbubur Rahman, Silvia Mateo-Lozano, Oscar M Tirado, Vicente Notario

Journal: Int. J. Oncol.. 2013 Sep;43(3):803-12.

 

The poor prognosis of Ewing's sarcoma (EWS), together with its high lethal recurrence rate and the side‑effects of current treatments, call for novel targeted therapies with greater curative effectiveness and substantially reduced side‑effects. The oncogenic chimeric protein EWS/FLI1 ...

Last Updated: 18 Jul 2013

Go To URL
Potential of herpesvirus saimiri-based vectors to reprogram a somatic Ewing's sarcoma family tumor cell line.
 

Author(s): Hannah F Brown, Christian Unger, Adrian Whitehouse

Journal: J. Virol.. 2013 Jun;87(12):7127-39.

 

Herpesvirus saimiri (HVS) infects a range of human cell types with high efficiency. Upon infection, the viral genome can persist as high-copy-number, circular, nonintegrated episomes that segregate to progeny cells upon division. This allows HVS-based vectors to stably transduce a ...

Last Updated: 29 May 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ewing's Sarcoma" returned 23 free, full-text review articles on human participants. First 3 results:

Primary Ewing's sarcoma/primitive neuroectodermal tumor of the urogenital tract in children.
 

Author(s): Hong-cheng Song, Ning Sun, Wei-ping Zhang, Cheng-ru Huang

Journal: Chin. Med. J.. 2012 Mar;125(5):932-6.

 

Primary Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) of urogenital tract is a rare condition with non-specific clinical presentations, which can make it difficult to diagnose. In this study, we summarize the clinical presentation, pathological features, therapeutic strategies, ...

Last Updated: 11 Apr 2012

Go To URL
Promiscuous partnerships in Ewing's sarcoma.
 

Author(s): Savita Sankar, Stephen L Lessnick

Journal: Cancer Genet. 2011 Jul;204(7):351-65.

 

Ewing's sarcoma is a highly aggressive bone and soft tissue tumor of children and young adults. At the molecular genetic level Ewing's sarcoma is characterized by a balanced reciprocal translocation, t(11;22)(q24;q12), which encodes an oncogenic fusion protein and transcription factor ...

Last Updated: 29 Aug 2011

Go To URL
Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing's sarcoma.
 

Author(s): Xing Dai, Wei Ma, Xijing He, Rajiv Kumar Jha

Journal: Med. Sci. Monit.. 2011 Aug;17(8):RA177-190.

 

The most prevalent forms of bone cancer are osteosarcoma, chondrosarcoma, and Ewing's sarcoma. Although chemotherapy and radiotherapy have replaced traditional surgical treatments, survival rates have undergone only marginal improvements. Current knowledge of the molecular pathways ...

Last Updated: 1 Aug 2011

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Whole-Body Radiation Therapy, Systemic Chemotherapy, and High-Dose Chemotherapy Followed By Stem Cell Rescue in Treating Patients With Poor-Risk Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Adult Supratentorial Primitive Neuroectodermal Tumor (PNET); Ewing Sarcoma of Bone; Extraosseous Ewing Sarcoma; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor

 

Last Updated: 11 Feb 2014

Go to URL
Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Adult Supratentorial Primitive Neuroectodermal Tumor (PNET); Childhood Supratentorial Primitive Neuroectodermal Tumor; Ewing Sarcoma of Bone; Extraosseous Ewing Sarcoma; Extraosseous Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Peripheral Primitive Neuroectodermal Tumor of the Kidney; Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor

 

Last Updated: 5 Feb 2014

Go to URL
Collecting and Storing Biological Samples From Patients With Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Askin Tumor; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

 

Last Updated: 18 Feb 2014

Go to URL