Ewing Sarcoma

Common Name(s)

Ewing Sarcoma

Ewing's sarcoma is a malignant (cancerous) bone tumor that affects children. It can occur any time during childhood and young adulthood, but usually develops during puberty, when bones are growing rapidly. The tumor may arise anywhere in the body, usually in the long bones of the arms and legs, the pelvis, or the chest. It may also develop in the skull or the flat bones of the trunk. There are few symptoms. The most common is pain and occasionally swelling at the site of the tumor. Fever may also be present. The tumor often spreads (metastasis) to the lungs and other bones. The cause of Ewing's sarcoma is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ewing Sarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ewing Sarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ewing Sarcoma" returned 311 free, full-text research articles on human participants. First 3 results:

MiR-193b, downregulated in Ewing Sarcoma, targets the ErbB4 oncogene to inhibit anchorage-independent growth.
 

Author(s): Colin Moore, Janet K Parrish, Paul Jedlicka

Journal:

 

Ewing Sarcoma is an aggressive, oncofusion-driven, malignant neoplasm of bone and soft tissue affecting predominantly children and young adults. Seeking to identify potential novel therapeutic targets/agents for this disease, our previous studies uncovered microRNAs regulated by EWS/Fli1, ...

Last Updated: 25 May 2017

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Transcriptomic and proteomic insight into the effects of a defined European mistletoe extract in Ewing sarcoma cells reveals cellular stress responses.
 

Author(s): M Twardziok, D Meierhofer, S Börno, B Timmermann, S Jäger, Sengül Boral, A Eggert, C I Delebinski, G Seifert

Journal:

 

The hydrophobic triterpenes, oleanolic and betulinic acid as well as the hydrophilic mistletoe lectins and viscotoxins possess anticancer properties. They do all occur in combination in European mistletoe (Viscum album L.). Commercial Viscum album L. extracts are aqueous, excluding ...

Last Updated: 29 Apr 2017

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The histone demethylase KDM3A, and its downstream target MCAM, promote Ewing Sarcoma cell migration and metastasis.
 

Author(s): M Sechler, J K Parrish, D K Birks, P Jedlicka

Journal: Oncogene. 2017 Jul;36(29):4150-4160.

 

Ewing Sarcoma is the second most common solid pediatric malignant neoplasm of bone and soft tissue. Driven by EWS/Ets, or rarely variant, oncogenic fusions, Ewing Sarcoma is a biologically and clinically aggressive disease with a high propensity for metastasis. However, the mechanisms ...

Last Updated: 20 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ewing Sarcoma" returned 26 free, full-text review articles on human participants. First 3 results:

Ewing Sarcoma in the Right Ventricle.
 

Author(s): Marija Petrovic, Bihong Zhao, Manoj Thangam, Pranav Loyalka, L Maximilian Buja, Biswajit Kar, Igor D Gregoric

Journal:

 

Ewing sarcoma is the second most prevalent malignant primary bone tumor but constitutes only a small proportion of cardiac metastases. We present a case of asymptomatic Ewing sarcoma metastatic to the right ventricle. A 36-year-old man presented for evaluation and resection of a pedunculated ...

Last Updated: 25 Oct 2016

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Primary intestinal mold infection in children with solid tumors: a case report in an adolescent with Ewing sarcoma, and literature review.
 

Author(s): Aldo Naselli, Alberto Garaventa, Piero Buffa, Claudio Granata, Roberto Bandettini, Giuliana Cangemi, Andrea Moscatelli, Elio Castagnola

Journal: New Microbiol.. 2016 Jul;39(3):232-234.

 

We report a case of primary intestinal infection due to filamentous fungi in an adolescent with Ewing sarcoma. The clinical picture was that of peritonitis secondary to intestinal perforation and the diagnosis was established only on histopathological bases. This condition is very ...

Last Updated: 10 Jun 2016

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Multiple Ewing Sarcoma/Primitive Neuroectodermal Tumors in the Mediastinum: A Case Report and Literature Review.
 

Author(s): Sung Hwan Bae, Jung Hwa Hwang, Bo Da Nam, Hyun Jo Kim, Ki-Up Kim, Dong Won Kim, In Ho Choi

Journal: Medicine (Baltimore). 2016 Feb;95(7):e2725.

 

Ewing sarcoma/primitive neuroectodermal tumors (ES/PNET) are high-grade malignant neoplasms. These malignancies present very rare tumors of thoracopulmonary area and even rarer in the mediastinum. In our knowledge, ES/PNET presented with multiple mediastinal masses has not been reported ...

Last Updated: 18 Feb 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy of Dose Intensification in Patients With Non-metastatic Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Ewing's Sarcoma

 

Last Updated: 26 Apr 2017

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Study in Localized and Disseminated Ewing Sarcoma
 

Status: Recruiting

Condition Summary: Ewing's Sarcoma

 

Last Updated: 19 May 2016

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Single Patient Expanded Access to Ganitumab for Metastatic Ewing Sarcoma
 

Status: Available

Condition Summary: Ewing Sarcoma

 

Last Updated: 23 Jan 2017

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