Lennox-Gastaut Syndrome

Common Name(s)

Lennox-Gastaut Syndrome, Epileptic Encephalopathy Lennox-Gastaut Type

Lennox-Gastaut syndrome is a form of severe epilepsy that begins in childhood. It is characterized by multiple types of seizures and intellectual disability. This condition can be caused by brain malformations, perinatal asphyxia (lack of oxygen), severe head injury, central nervous system infection and inherited degenerative or metabolic conditions. In about one-third of cases, no cause can be found. Treatment for Lennox-Gastaut syndrome includes anti-epileptic medications such as valproate, lamotrigine, felbamate, or topiramate. There is usually no single antiepileptic medication that will control seizures. Children may improve initially, but many later show tolerance to a drug or develop uncontrollable seizures. .
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lennox-Gastaut Syndrome" for support, advocacy or research.

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CNS Foundation

CNS Foundation's Mission is Three-fold: - Expedite scientific research to find treatments and cures for the more than 14 million children living with some form of neurological disorder - Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology - Educate the public, and public officials, on the critical importance of funding pediatric neurological disorder research

http://www.cnsfoundation.org

Last Updated: 12 Oct 2013

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International Foundation for CDKL5 Research

To lead the way in finding a cure and treatments for CDKL5 disorder by funding global research efforts and increasing awareness while enhancing the quality of life for those affected by CDKL5 disorder, by providing information, programs, and services.

http://www.CDKL5.com

Last Updated: 19 Feb 2013

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LGS Foundation

The LGS Foundation is a not-for-profit organization dedicated to providing information about Lennox-Gastaut Syndrome, a rare and severe form of childhood-onset epilepsy, while raising funds for research, programs, and services for individuals living with LGS, and their families.

http://www.lgsfoundation.org

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lennox-Gastaut Syndrome" for support, advocacy or research.

Logo
CNS Foundation

CNS Foundation's Mission is Three-fold: - Expedite scientific research to find treatments and cures for the more than 14 million children living with some form of neurological disorder - Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology - Educate the public, and public officials, on the critical importance of funding pediatric neurological disorder research

http://www.cnsfoundation.org

Last Updated: 12 Oct 2013

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International Foundation for CDKL5 Research

To lead the way in finding a cure and treatments for CDKL5 disorder by funding global research efforts and increasing awareness while enhancing the quality of life for those affected by CDKL5 disorder, by providing information, programs, and services.

http://www.CDKL5.com

Last Updated: 19 Feb 2013

View Details
LGS Foundation

The LGS Foundation is a not-for-profit organization dedicated to providing information about Lennox-Gastaut Syndrome, a rare and severe form of childhood-onset epilepsy, while raising funds for research, programs, and services for individuals living with LGS, and their families.

http://www.lgsfoundation.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lennox-Gastaut Syndrome" returned 15 free, full-text research articles on human participants. First 3 results:

Surgical treatment of patients with Lennox-Gastaut syndrome phenotype.
 

Author(s): Shi-Yong Liu, Ning An, Xiang Fang, Prabhdeep Singh, Joseph Oommen, Qing Yin, Mei-Hua Yang, Yong Liu, Wei Liao, Chang-Qing Gao, Hui Yang

Journal: ScientificWorldJournal. 2012 ;2012():614263.

 

Lennox-Gastaut syndrome (LGS) is a devastating and refractory generalized epilepsy affecting children and adolescents. In this study we report the results of resective surgery in 18 patients with LGS phenotype who underwent single-lobe/lesionectomy or multilobe resection plus multiple ...

Last Updated: 25 May 2012

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Late-onset Lennox-Gastaut syndrome as a phenotype of 15q11.1q13.3 duplication.
 

Author(s): João Rocha, Cátia Guerra, Renata Oliveira, Sofia Dória, Ricardo Rego, Maria José Rosas

Journal: Epileptic Disord. 2012 Jun;14(2):159-62.

 

The clinical symptoms associated with chromosome 15q duplication syndrome manifest through a heterogeneous group of symptoms characterised by hypotonia, delay in motor skills and language development, cognitive and learning disabilities, autism spectrum disorder and refractory epilepsy. ...

Last Updated: 25 Jun 2012

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Levetiracetam efficacy in patients with Lennox-Gastaut syndrome. Presentation of a case.
 

Author(s): A Díaz Negrillo, F Martín Del Valle, M González Salaices, C Prieto Jurczynska, J Carneado Ruiz

Journal: Neurologia. 2011 Jun;26(5):285-90.

 

The Lennox-Gastaut syndrome (LGS) is one of the most severe epileptic encephalopathies of childhood, characterized by electro-clinical triad of generalized spike-wave activity, slow (POL) in the electroencephalogram (EEG), multiple types of seizures and development delay. This paper ...

Last Updated: 23 May 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lennox-Gastaut Syndrome" returned 4 free, full-text review articles on human participants. First 3 results:

Vagus nerve stimulation vs. corpus callosotomy in the treatment of Lennox-Gastaut syndrome: a meta-analysis.
 

Author(s): Guido Lancman, Michael Virk, Huibo Shao, Madhu Mazumdar, Jeffrey P Greenfield, Steven Weinstein, Theodore H Schwartz

Journal: Seizure. 2013 Jan;22(1):3-8.

 

Lennox-Gastaut syndrome (LGS) is an epileptogenic disorder that arises in childhood and is typically characterized by multiple seizure types, slow spike-and-wave complexes on EEG and cognitive impairment. If medical treatment fails, patients can proceed to one of two palliative surgeries, ...

Last Updated: 14 Jan 2013

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[Lennox-Gastaut syndrome--course and treatment].
 

Author(s): Caroline Lund, Eylert Brodtkorb, Karl O Nakken

Journal: Tidsskr. Nor. Laegeforen.. 2011 Jan;131(1):24-7.

 

Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy, which starts in childhood with various seizure types. The children develop cognitive impairment and a typical EEG pattern. The aim of this article is to describe the clinical presentation of LGS, with particular emphasis ...

Last Updated: 14 Jan 2011

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[The value of topiramate used with conventional schemes as an adjunctive therapy in the treatment of Lennox-Gastaut syndrome].
 

Author(s): E Alva-Moncayo, A Ruiz-Ruiz

Journal: Rev Neurol. ;36(5):453-7.

 

Lennox Gastaut syndrome (LGS), which appears in children aged between 2 and 8 years old, is characterised by a triad of epileptic seizures with different patterns, variable degrees of mental retardation, an electroencephalogram (EEG) with slow spike wave complexes at 1.5 4 Hz and ...

Last Updated: 17 Mar 2003

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological Effects
 

Status: Not yet recruiting

Condition Summary: Lennox-Gastaut Syndrome

 

Last Updated: 9 Jun 2011

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