Epidermal nevus

Common Name(s)

Epidermal nevus

Epidermal nevi are congenital lesions that affect about 1 in 1,000 people. They appear at or shortly after birth as localized epidermal thickening with hyperpigmentation that frequently follow the lines of Blaschko, suggesting that they result from postzygotic somatic mutation in the skin ({11:Paller et al., 1994}). A rare subgroup of epidermal nevi is clinically indistinguishable from other epidermal nevi, but displays histopathologic features typical of epidermolytic hyperkeratosis (see EHK, {113800}), and patients with this type of epidermal nevi sometimes have offspring with generalized EHK ({11:Paller et al., 1994}). See giant pigmented hairy nevus ({137550}) and malignant melanoma ({155600}). Nevus sebaceous is a benign congenital skin lesion that preferentially affects the scalp and face. It occurs in about 1 in 1,000 live births and is characterized by hairless, yellow-orange plaques of various size and shape. Histology shows that nevus sebaceous is a hamartoma consisting of epidermal, sebaceous, and apocrine elements. About 24% of nevi develop secondary tumors, some of which may be malignant (summary by {5:Groesser et al., 2012}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Epidermal nevus" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Epidermal nevus" returned 37 free, full-text research articles on human participants. First 3 results:

Involucrin in the differential diagnosis between linear psoriasis and inflammatory linear verrucous epidermal nevus: a report of one case.
 

Author(s): Flávia Regina Ferreira, Nilton Gioia Di Chiacchio, Márcia Lanzoni de Alvarenga, Samuel Henrique Mandelbaum

Journal: An Bras Dermatol. ;88(4):604-7.

 

Inflammatory linear verrucous epidermal nevus is a variant of verrucous epidermal nevus, characterized by recurrent inflammatory phenomena. Despite well-established clinical manifestations, the differential diagnosis between inflammatory linear verrucous epidermal nevus and linear ...

Last Updated: 26 Sep 2013

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Is it inflammatory linear verrucous epidermal nevus or linear psoriasis?
 

Author(s): Bin Yin, Yu-ping Ran, Peng Wang, Jebina Lama

Journal: Chin. Med. J.. 2013 ;126(9):1794-5.

 

Last Updated: 8 May 2013

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An inflammatory verrucous epidermal nevus concomitant with psoriasis: treatment with adalimumab.
 

Author(s): Mustafa Özdemir, Ali Balevi, Hasan Esen

Journal:

 

A 42-year-old-man presented with generalized inflammatory linear verrucous epidermal nevus with concomitant psoriasis vulgaris. Because of unresponsiveness of the conventional treatment, we considered treatment with adalimumab. Adalimumab was well tolerated and no side effects were ...

Last Updated: 5 Nov 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Epidermal nevus" returned 2 free, full-text review articles on human participants. First 3 results:

Oral linear epidermal nevus: a review of the literature and report of two new cases.
 

Author(s): Domenico Tesi, Giuseppe Ficarra

Journal: Head Neck Pathol. 2010 Jun;4(2):139-43.

 

Linear epidermal nevus (LEN) is a sporadic hamartomatous lesion of the skin due to the proliferation of clones of embryonic ectodermal cells, which are arranged according to a typical linear configuration known as Blaschko's lines. Oral involvement of LEN is very rare and few cases ...

Last Updated: 31 May 2010

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Linear Cowden nevus: a new distinct epidermal nevus.
 

Author(s): Rudolf Happle

Journal: Eur J Dermatol. ;17(2):133-6.

 

Within the group of epidermal nevi, a so far nameless disorder is described under the term "linear Cowden nevus". This non-organoid epidermal nevus is caused by loss of heterozygosity, occurring at an early developmental stage in an embryo with a germline PTEN mutation, giving rise ...

Last Updated: 15 Mar 2007

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Symptoms, Diagnosis, and Treatment

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