Dystonia 1

Common Name(s)

Dystonia 1

'Dystonia' describes a neurologic condition characterized by involuntary, sustained muscle contractions affecting one or more sites of the body; 'torsion' refers to the twisting nature of body movements observed in dystonia. Dystonia has been classified as primary (dystonia as the sole or major symptom) or secondary (a symptom of another disorder), and by age of onset, muscle groups affected, and mode of inheritance ({42:Muller and Kupke, 1990}; {44:Nemeth, 2002}).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dystonia 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dystonia 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dystonia 1" returned 14 free, full-text research articles on human participants. First 3 results:

Dysport and Botox at a ratio of 2.5:1 units in cervical dystonia: a double-blind, randomized study.
 

Author(s): Ji Young Yun, Jae Woo Kim, Hee-Tae Kim, Sun Ju Chung, Jong-Min Kim, Jin Whan Cho, Jee-Young Lee, Ha Neul Lee, Sooyeoun You, Eungseok Oh, Heejeong Jeong, Young Eun Kim, Han-Joon Kim, Won Yong Lee, Beom S Jeon

Journal: Mov. Disord.. 2015 Feb;30(2):206-13.

 

We aimed to compare Dysport (abobotulinumtoxinA, Ipsen Biopharm, Slough, UK) and Botox (onabotulinumtoxinA, Allergan, Irvine, CA, USA) at a 2.5:1 ratio in the treatment of cervical dystonia (CD). A Dysport/Botox ratio of lower than 3:1 was suggested as a more appropriate conversion ...

Last Updated: 4 Feb 2015

Go To URL
Parkinsonism in GTP cyclohydrolase 1-deficient DOPA-responsive dystonia.
 

Author(s): Yoshiaki Furukawa, Stephen J Kish

Journal: Brain. 2015 May;138(Pt 5):e351.

 

Last Updated: 24 Apr 2015

Go To URL
Blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentration in dystonia cases vs. controls.
 

Author(s): Elan D Louis, Pam Factor-Litvak, Monika Michalec, Wendy Jiang, Wei Zheng

Journal: Neurotoxicology. 2014 Sep;44():110-3.

 

Harmane (1-methyl-9H-pyrido[3,4-b]indole) (HA) is a potent neurotoxin that has been linked to two neurological diseases, essential tremor and Parkinson's disease. Blood harmane concentrations [HA] are elevated in patients with both diseases. An important question is whether HA is ...

Last Updated: 24 Sep 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dystonia 1" returned 2 free, full-text review articles on human participants. First 3 results:

Guanine triphosphate-cyclohydrolase 1-deficient dopa-responsive dystonia presenting as frequent falling in 2 children.
 

Author(s): Chang-Yong Tsao

Journal: J. Child Neurol.. 2012 Mar;27(3):389-91.

 

Guanine triphosphate (GTP)-cyclohydrolase 1 (GCH1)-deficient dopa-responsive dystonia is caused by GCH1 gene mutation. Two children presenting with frequent daily falling are reported with GCH1 gene mutations with persistent response to low-dose levodopa/carbidopa. Typical and atypical ...

Last Updated: 20 Mar 2012

Go To URL
Autosomal dominant GTP cyclohydrolase I (AD GCH 1) deficiency (Segawa disease, dystonia 5; DYT 5).
 

Author(s): Masaya Segawa

Journal: Chang Gung Med J. ;32(1):1-11.

 

Autosomal dominant GTP cyclohydrolase I (AD GCH 1) deficiency (Segawa disease) is an autosomal dominant dopa responsive dystonia caused by heterozygous mutation of the GCH 1 gene located on 14q22.1-q22.2. Although a number of mutations have been reported, the change remains highly ...

Last Updated: 18 Mar 2009

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Ampicillin for DYT-1 Dystonia Motor Symptoms
 

Status: Recruiting

Condition Summary: DYT-1; Dystonia

 

Last Updated: 13 Sep 2016

Go to URL
Identification, Prevalence, and Lifespan of Rapid-Onset Dystonia-Parkinsonism
 

Status: Recruiting

Condition Summary: Dystonia; Parkinsonism

 

Last Updated: 8 Dec 2014

Go to URL
WILSTIM - DBS (WILson STIMulation - Deep Brain Stimulation)
 

Status: Not yet recruiting

Condition Summary: Severe Dystonia; Wilson's Disease

 

Last Updated: 17 Sep 2015

Go to URL