Diabetes mellitus type 1

Common Name(s)

Diabetes mellitus type 1

Diabetes mellitus type 1 (DM1) is a condition in which cells in the pancreas (beta cells) stop producing insulin, causing abnormally high blood sugar levels. Lack of insulin results in the inability of the body to use glucose for energy and control the amount of sugar in the blood. DM1 can occur at any age, but usually develops by early adulthood, most often in adolescence. Symptoms of high blood sugar may include frequent urination, excessive thirst, fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. The exact cause of DM1 is unknown, but having certain "variants" of specific genes may increase a person's risk to develop the condition. A predisposition to develop DM1 runs in families, but no known inheritance pattern exists. Treatment includes blood sugar control and insulin replacement therapy. Improper control can cause recurrence of high blood sugar, or abnormally low blood sugar (hypoglycemia) during exercise or when eating is delayed. If not treated, the condition can be life-threatening. Over many years, chronic high blood sugar may be associated with a variety of complications that affect many parts of the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes mellitus type 1" for support, advocacy or research.

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Diabetes Hands Foundation

We work to connect, engage, and empower people touched by diabetes while keeping in mind a vision of a world where people with diabetes and their loved ones do not feel alone, understand and manage a life with diabetes and work together towards a better future.

Last Updated: 6 Mar 2013

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Taking Control of Your Diabetes

Guided by the belief that every person with diabetes has the right to live a healthy, happy, and productive life, Taking Control of Your Diabetes educates and motivates people with diabetes to take a more active role in their condition and provides innovative and integrative continuing diabetes education to medical professionals caring for people with diabetes.

Last Updated: 28 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes mellitus type 1" for support, advocacy or research.

Logo
Diabetes Hands Foundation

We work to connect, engage, and empower people touched by diabetes while keeping in mind a vision of a world where people with diabetes and their loved ones do not feel alone, understand and manage a life with diabetes and work together towards a better future.

http://www.diabeteshandsfoundation.org

Last Updated: 6 Mar 2013

View Details
Logo
Taking Control of Your Diabetes

Guided by the belief that every person with diabetes has the right to live a healthy, happy, and productive life, Taking Control of Your Diabetes educates and motivates people with diabetes to take a more active role in their condition and provides innovative and integrative continuing diabetes education to medical professionals caring for people with diabetes.

http://www.tcoyd.org

Last Updated: 28 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diabetes mellitus type 1" returned 604 free, full-text research articles on human participants. First 3 results:

Assessment of skeletal and dental ages of children and adolescents with type 1 diabetes mellitus.
 

Author(s): Ilana Sanamaika Queiroga Bezerra, Francielle Topolski, Suzana Nesi França, Márcia Rejane Brücker, Ângela Fernandes

Journal: Braz Oral Res. 2015 ;29():.

 

The present study aimed to assess the skeletal and dental ages of type 1 diabetes mellitus (T1DM) patients. Therefore, panoramic and hand-wrist radiographs of 82 patients, aged between 5 and 15 years, were collected and divided into case and control groups. The case group consisted ...

Last Updated: 28 Jan 2015

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Arresting beta-cell destruction in type 1 diabetes mellitus: mobilizing homuncultar autoimmunity to treat autoimmune disease.
 

Author(s): Irun R Cohen

Journal: Isr. Med. Assoc. J.. 2014 Oct;16(10):638-9.

 

Last Updated: 2 Dec 2014

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Effect of the ingestion of the palm oil and glutamine in serum levels of GLP-1, PYY and glycemia in diabetes mellitus type 2 patients submitted to metabolic surgery.
 

Author(s): Tharsus Dias Takeuti, Guilherme Azevedo Terra, Alex Augusto da Silva, Júverson Alves Terra, Luci Mara da Silva, Eduardo Crema

Journal: Arq Bras Cir Dig. 2014 ;27 Suppl 1():51-5.

 

Incretins are hormones produced by the intestine and can stimulate the secretion of insulin, helping to diminish the post-prandial glycemia. The administration of an emulsion of palm oil can help in the maintenance of the weight, and can increase circulating incretins levels. Glutamine ...

Last Updated: 21 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diabetes mellitus type 1" returned 80 free, full-text review articles on human participants. First 3 results:

Fulminant type 1 diabetes mellitus and fulminant viral myocarditis. A case report and literature review.
 

Author(s): Nobumasa Ohara, Masanori Kaneko, Hirohiko Kuwano, Katsuya Ebe, Toshio Fujita, Tsuneo Nagai, Tatsuo Furukawa, Yoshifusa Aizawa, Kyuzi Kamoi

Journal: Int Heart J. 2015 ;56(2):239-44.

 

A 35-year-old Japanese woman was admitted with coma following flu-like symptoms. She was diagnosed with diabetic ketoacidosis and fulminant type 1 diabetes (FT1D) and received intravenous infusion of insulin and saline. The next day, the ketoacidosis disappeared, and she recovered ...

Last Updated: 23 Mar 2015

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Nonhuman primate models of type 1 diabetes mellitus for islet transplantation.
 

Author(s): Haitao Zhu, Liang Yu, Yayi He, Bo Wang

Journal: J Diabetes Res. 2014 ;2014():785948.

 

Islet transplantation is an attractive treatment of type 1 diabetes mellitus (T1DM). Animal models of diabetes mellitus (DM) contribute a lot to the experimental studies of islet transplantation and to evaluations of isolated islet grafts for future clinical applications. Diabetic ...

Last Updated: 12 Nov 2014

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Physical activity interventions in children and young people with Type 1 diabetes mellitus: a systematic review with meta-analysis.
 

Author(s): H Quirk, H Blake, R Tennyson, T L Randell, C Glazebrook

Journal: Diabet. Med.. 2014 Oct;31(10):1163-73.

 

To synthesize evidence from randomized and non-randomized studies of physical activity interventions in children and young people with Type 1 diabetes so as to explore clinically relevant health outcomes and inform the promotion of physical activity.

Last Updated: 17 Sep 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation of Vildagliptin (Galvus®) as add-on to Insulin in New-onset Type 1 Diabetes Mellitus
 

Status: Recruiting

Condition Summary: Type 1 Diabetes; Insulin Dependent Diabetes; Juvenile Onset Diabetes Mellitus; Autoimmune Diabetes

 

Last Updated: 13 May 2014

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Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study
 

Status: Recruiting

Condition Summary: Diabetes Mellitus Type 1

 

Last Updated: 18 Nov 2013

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Last Updated: 15 May 2015

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