Dandy-Walker Syndrome

Common Name(s)

Dandy-Walker Syndrome, Dandy-Walker complex

Dandy-Walker malformation is defined by hypoplasia and upward rotation of the cerebellar vermis and cystic dilation of the fourth ventricle. Affected individuals often have motor deficits such as delayed motor development, hypotonia, and ataxia; about half have mental retardation and some have hydrocephalus. DWM is a heterogeneous disorder. The low empiric recurrence risk of approximately 1 to 2% for nonsyndromic DWM suggests that mendelian inheritance is unlikely (summary by {11:Murray et al., 1985}).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dandy-Walker Syndrome" for support, advocacy or research.

Logo
CNS Foundation

CNS Foundation's Mission is Three-fold: - Expedite scientific research to find treatments and cures for the more than 14 million children living with some form of neurological disorder - Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology - Educate the public, and public officials, on the critical importance of funding pediatric neurological disorder research

Last Updated: 12 Oct 2013

View Details
Dandy-Walker Alliance, Inc.

The Dandy-Walker Alliance, Inc. is a non-profit corporation providing support and outreach to families, producing educational publications, hosting awareness events and programs, and funding research for the most common malformation of the hindbrain region, Dandy-Walker Syndrome. We support all efforts to determine the causes of, find the cure for and to ameliorate the effects of Dandy-Walker Syndrome.

Last Updated: 13 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dandy-Walker Syndrome" for support, advocacy or research.

Logo
CNS Foundation

CNS Foundation's Mission is Three-fold: - Expedite scientific research to find treatments and cures for the more than 14 million children living with some form of neurological disorder - Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology - Educate the public, and public officials, on the critical importance of funding pediatric neurological disorder research

http://www.cnsfoundation.org

Last Updated: 12 Oct 2013

View Details
Dandy-Walker Alliance, Inc.

The Dandy-Walker Alliance, Inc. is a non-profit corporation providing support and outreach to families, producing educational publications, hosting awareness events and programs, and funding research for the most common malformation of the hindbrain region, Dandy-Walker Syndrome. We support all efforts to determine the causes of, find the cure for and to ameliorate the effects of Dandy-Walker Syndrome.

http://www.dandy-walker.org

Last Updated: 13 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dandy-Walker Syndrome" returned 12 free, full-text research articles on human participants. First 3 results:

Dandy-Walker malformation and Wisconsin syndrome: novel cases add further insight into the genotype-phenotype correlations of 3q23q25 deletions.
 

Author(s): Alessandro Ferraris, Laura Bernardini, Vesna Sabolic Avramovska, Ginevra Zanni, Sara Loddo, Elena Sukarova-Angelovska, Valentina Parisi, Anna Capalbo, Stefano Tumini, Lorena Travaglini, Francesca Mancini, Filip Duma, Sabina Barresi, Antonio Novelli, Eugenio Mercuri, Luigi Tarani, , Enrico Bertini, Bruno Dallapiccola, Enza Maria Valente

Journal:

 

The Dandy-Walker malformation (DWM) is one of the commonest congenital cerebellar defects, and can be associated with multiple congenital anomalies and chromosomal syndromes. The occurrence of overlapping 3q deletions including the ZIC1 and ZIC4 genes in few patients, along with data ...

Last Updated: 30 May 2013

Go To URL
[Dandy-Walker syndrome].
 

Author(s): Jesús Rodríguez Virgili, Alberto A Cabal García

Journal: Aten Primaria. 2010 Jan;42(1):50-1.

 

Last Updated: 19 Jan 2010

Go To URL
[Quantitative analysis of cerebellar vermis in fetuses with Dandy-Walker syndrome with three-dimensional ultrasonography].
 

Author(s): Hong-Ning Xie, Dan-Lei Cai, Hua He, Yun-Xiao Zhu, Li-Juan Li

Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008 Feb;30(1):80-5.

 

To evaluate the third plane image of the three-dimensional sonography (3D US) for the quantitative analysis of the cerebellar vermis in normal and Dandy-Walker syndrome (DWS) fetuses.

Last Updated: 25 Mar 2008

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dandy-Walker Syndrome" returned 0 free, full-text review articles on human participants.

 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Clinical and Molecular Investigations Into Ciliopathies
 

Status: Recruiting

Condition Summary: Autosomal Recessive Polycystic Kidney Disease; Congenital Hepatic Fibrosis; Caroli's Disease; Polycystic Kidney Disease; Joubert Syndrome; Cerebro-Oculo-Renal Syndromes; COACH Syndrome; Senior-Loken Syndrome; Dekaban-Arima Syndrome; Cogan Oculomotor Apraxia; Nephronophthisis; Bardet-Biedl Syndrome; Alstrom Syndrome; Oral-Facial-Digital Syndrome

 

Last Updated: 14 Mar 2014

Go to URL
Genetic Analysis of PHACE Syndrome (Hemangioma With Other Congenital Anomalies)
 

Status: Recruiting

Condition Summary: PHACE Syndrome

 

Last Updated: 31 Oct 2013

Go to URL
Brain Development Research Program
 

Status: Recruiting

Condition Summary: Brain Disorders; Aicardi Syndrome

 

Last Updated: 16 May 2013

Go to URL