Cyclic Neutropenia

Common Name(s)

Cyclic Neutropenia, Cyclic Hematopoiesis

Cyclic neutropenia is a rare blood disorder characterized by recurrent episodes of abnormally low levels of neutrophils (a type of white blood cell) in the body. Neutrophils are instrumental in fighting off infection by surrounding and destroying bacteria that enter the body. Symptoms of cyclic neutropenia may include fever, a general feeling of ill health, and/or sores (ulcers) of the mucous membranes of the mouth. Individuals with low levels of neutrophils (neutropenia) are highly susceptible to recurrent infections. Cyclic neutropenia may be inherited or acquired. Some cases are present at birth and appear to occur randomly for no apparent reason (sporadic). Inherited cases appear to be transmitted in an autosomal dominant fashion and caused by mutations in the ELANE gene.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cyclic Neutropenia" for support, advocacy or research.

National Neutropenia Network Inc.

To promote awareness, education, and research, and to provide a support system for patients with severe chronic neutropenia and their families through a national resource network.

Last Updated: 29 Apr 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cyclic Neutropenia" for support, advocacy or research.

National Neutropenia Network Inc.

To promote awareness, education, and research, and to provide a support system for patients with severe chronic neutropenia and their families through a national resource network.

http://www.neutropenianet.org/

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cyclic Neutropenia" returned 33 free, full-text research articles on human participants. First 3 results:

A case report of cyclic neutropenia associated with pyoderma gangrenosum.
 

Author(s): Hossain Jabbari, Fatemeh Payvarmehr, SeyedAhmad SeyedAlinaghi, Neda Roosta

Journal: Acta Med Iran. 2011 ;49(11):763-5.

 

We present a 24-year-old female referred with non-healing wound of a few days duration on anterior aspect of her right foreleg. Biopsy of the wound was reported to be pyoderma gangrenosum on pathologic report. Further work up of the patient for high grade fever and occasional leukopenias ...

Last Updated: 1 Dec 2011

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Cyclic neutropenia and severe congenital neutropenia in patients with a shared ELANE mutation and paternal haplotype: evidence for phenotype determination by modifying genes.
 

Author(s): Peter E Newburger, Talia N Pindyck, Zhiqing Zhu, Audrey Anna Bolyard, Andrew A G Aprikyan, David C Dale, Gary D Smith, Laurence A Boxer

Journal: Pediatr Blood Cancer. 2010 Aug;55(2):314-7.

 

Cyclic neutropenia (CN) and severe congenital neutropenia (SCN) are disorders of neutrophil production that differ markedly in disease severity. Mutations of the ELANE gene (the symbol recently replacing ELA2) are considered largely responsible for most cases of CN and SCN, but specific ...

Last Updated: 1 Jul 2010

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Progenitor cell self-renewal and cyclic neutropenia.
 

Author(s): D Dingli, T Antal, A Traulsen, J M Pacheco

Journal: Cell Prolif.. 2009 Jun;42(3):330-8.

 

Cyclic neutropenia (CN) is a rare genetic disorder where patients experience regular cycling of numbers of neutrophils and various other haematopoietic lineages. The nadir in neutrophil count is the main source of problems due to risk of life-threatening infections. Patients with ...

Last Updated: 12 Jun 2009

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cyclic Neutropenia" returned 3 free, full-text review articles on human participants. First 3 results:

ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology.
 

Author(s): Marshall S Horwitz, Seth J Corey, H Leighton Grimes, Timothy Tidwell

Journal: Hematol. Oncol. Clin. North Am.. 2013 Feb;27(1):19-41, vii.

 

The 2 main forms of hereditary neutropenia are cyclic (CN) and severe congenital (SCN) neutropenia. CN is an autosomal dominant disorder in which neutrophil counts fluctuate with 21-day periodicity. SCN consists of static neutropenia, with promyelocytic maturation arrest in the bone ...

Last Updated: 28 Jan 2013

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Neutrophil elastase in cyclic and severe congenital neutropenia.
 

Author(s): Marshall S Horwitz, Zhijun Duan, Brice Korkmaz, Hu-Hui Lee, Matthew E Mealiffe, Stephen J Salipante

Journal: Blood. 2007 Mar;109(5):1817-24.

 

Mutations in ELA2 encoding the neutrophil granule protease, neutrophil elastase (NE), are the major cause of the 2 main forms of hereditary neutropenia, cyclic neutropenia and severe congenital neutropenia (SCN). Genetic evaluation of other forms of neutropenia in humans and model ...

Last Updated: 21 Feb 2007

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A patient with cyclic neutropenia complicated by severe persistent neutropenia successfully delivered a healthy baby.
 

Author(s): T Abe, H Azuma, A Watanabe, T Shigekiyo, S Endou, R Pou, R Fukui, K Maeda, T Aono, T Matsumoto

Journal: Intern. Med.. 2000 Aug;39(8):663-6.

 

We describe a 24-year-old pregnant woman complicated by cyclic neutropenia (CN), who was successfully treated with granulocyte-colony stimulating factor (G-CSF). Her white blood cell (WBC) and neutrophil count fluctuated from 2,600 to 4,600/microl, and 26 to 2,530/microl, respectively. ...

Last Updated: 21 Nov 2000

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety and Efficacy of YPEG-rhG-CSF in Cancer Patients Receiving Chemotherapy
 

Status: Recruiting

Condition Summary: Non Small Cell Lung Cancer; Breast Cancer

 

Last Updated: 10 Jul 2014

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