Crigler-Najjar syndrome

Common Name(s)

Crigler-Najjar syndrome

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Crigler-Najjar syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Crigler-Najjar syndrome" returned 29 free, full-text research articles on human participants. First 3 results:

UGT1A1 gene mutation due to Crigler-Najjar syndrome in Iranian patients: identification of a novel mutation.
 

Author(s): Javad Mohammadi Asl, Mohammad Amin Tabatabaiefar, Hamid Galehdari, Kourosh Riahi, Mohammad Hosein Masbi, Zohre Zargar Shoshtari, Fakher Rahim

Journal: Biomed Res Int. 2013 ;2013():342371.

 

Crigler-Najjar syndrome (CNS) type I and type II are inherited as autosomal recessive conditions that are caused by mutations in the UGT1A1 gene. We present the analysis of UGT1A1 gene in 12 individuals from three different families. This analysis allowed us to identify one novel ...

Last Updated: 28 Nov 2013

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Role of a homozygous A(TA)₇TAA promoter polymorphism and an exon 1 heterozygous frameshift mutation UGT1A1 in Crigler-Najjar syndrome type II in a Thai neonate.
 

Author(s): P Nilyanimit, A Krasaelap, M Foonoi, V Chongsrisawat, Y Poovorawan

Journal:

 

Crigler-Najjar syndrome is a rare autosomal recessive disease caused by mutations in the UGT1A1 gene. These mutations result in the deficiency of UGT1A1, a hepatic enzyme essential for bilirubin conjugation. This report describes the case of a 4-month-old boy with the cardinal symptoms ...

Last Updated: 25 Sep 2013

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Liver transplantation in Crigler-Najjar syndrome type I disease.
 

Author(s): Zhen-Hua Tu, De-Sheng Shang, Jin-Cai Jiang, Wu Zhang, Min Zhang, Wei-Lin Wang, Hai-Yan Lou, Shu-Sen Zheng

Journal: HBPD INT. 2012 Oct;11(5):545-8.

 

Crigler-Najjar syndrome type I (CNS I) is a very rare autosomal recessive inherited disease that liver transplantation can properly deal with.

Last Updated: 12 Oct 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Crigler-Najjar syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

Neurophysiological follow-up of two siblings with Crigler-Najjar syndrome type I and review of literature.
 

Author(s): Erhan Bayram, Yeşim Öztürk, Semra Hız, Yasemin Topçu, Murat Kılıç, Murat Zeytunlu

Journal: Turk. J. Pediatr.. ;55(3):349-53.

 

Crigler-Najjar syndrome type I is an autosomal recessive inherited disease and rarely seen in childhood. Bilirubin neurotoxicity is the morbidity of the disease due to the elevated unconjugated bilirubin levels. Mental retardation, seizures, cognitive dysfunction, oculomotor nerve ...

Last Updated: 12 Nov 2013

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Pregnancy outcome in maternal Crigler-Najjar syndrome type II: a case report and systematic review of the literature.
 

Author(s): V Passuello, A G Puhl, S Wirth, E Steiner, C Skala, H Koelbl, N Kohlschmidt

Journal: Fetal. Diagn. Ther.. 2009 ;26(3):121-6.

 

To report a case of maternal Crigler-Najjar syndrome (CNS) type II in pregnancy, systematically review the literature for similar case reports, and to evaluate whether pregnancy is safe in patients with the disease. Data sources included the PubMed and up to date databases.

Last Updated: 9 Dec 2009

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Liver cell transplantation for Crigler-Najjar syndrome type I: update and perspectives.
 

Author(s): Philippe-A Lysy, Mustapha Najimi, Xavier Stephenne, Annick Bourgois, Francoise Smets, Etienne-M Sokal

Journal: World J. Gastroenterol.. 2008 Jun;14(22):3464-70.

 

Liver cell transplantation is an attractive technique to treat liver-based inborn errors of metabolism. The feasibility and efficacy of the procedure has been demonstrated, leading to medium term partial metabolic control of various diseases. Crigler-Najjar is the paradigm of such ...

Last Updated: 20 Jun 2008

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Immunity Against AAV in Crigler Najjar Patient
 

Status: Recruiting

Condition Summary: Crigler Najjar Syndrome

 

Last Updated: 1 Dec 2014

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Comparison of Biofeedback vs. Botox Injection to Treat Levator Ani Syndrome
 

Status: Recruiting

Condition Summary: Levator Ani Syndrome With Pain and/or Constipation Symptoms.

 

Last Updated: 26 Nov 2007

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