Crigler-Najjar syndrome

Common Name(s)

Crigler-Najjar syndrome

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Crigler-Najjar syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Crigler-Najjar syndrome" returned 39 free, full-text research articles on human participants. First 3 results:

Spectrum of UGT1A1 Variations in Chinese Patients with Crigler-Najjar Syndrome Type II.
 

Author(s): Lufeng Li, Guohong Deng, Yi Tang, Qing Mao

Journal:

 

Crigler-Najjar Syndrome type II (CNS-II) is an autosomal recessive hereditary condition of unconjugated hyperbilirubinemia without hemolysis, with bilirubin levels ranging from 102.6 μmol/L to 342 μmol/L. CNS-II is caused by a deficiency of UDP-glucuronyl transferase (UGT), which ...

Last Updated: 21 May 2015

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Compound heterozygosity of a novel exon 3 frameshift (p.R357P fs*24) mutation and Y486D mutation in exon 5 of the UGT1A1 gene in a Thai infant with Crigler-Najjar syndrome type 2.
 

Author(s): L Tesapirat, P Nilyanimit, N Wanlapakorn, Y Poovorawan

Journal:

 

Mutations in the UGT1A1 gene cause Crigler-Najjar syndrome (CN), which causes non-hemolytic unconjugated hyperbilirubinemia, and is categorized as CN1 and CN2 according to the severity of bilirubin levels. The UGT1A1 gene is responsible for encoding the liver enzyme uridine diphosphate-glucuronosyltransferase, ...

Last Updated: 13 May 2015

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A novel stop codon mutation in exon 1 (558C>A) of the UGT1A1 gene in a Thai neonate with Crigler-Najjar syndrome type I.
 

Author(s): N Wanlapakorn, P Nilyanimit, T Vorawandthanachai, T Deesudjit, N Dumrongpisutikul, Y Poovorawan

Journal:

 

Human uridine 5'-diphosphate-glucuronosyltransferases play a critical role in detoxification by conjugating bilirubin with glucoronic acid. Impaired or reduced enzymatic activity causes a spectrum of clinical disorders such as Crigler-Najjar syndrome type I (CN1), Crigler-Najjar syndrome ...

Last Updated: 3 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Crigler-Najjar syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

Neurophysiological follow-up of two siblings with Crigler-Najjar syndrome type I and review of literature.
 

Author(s): Erhan Bayram, Yeşim Öztürk, Semra Hız, Yasemin Topçu, Murat Kılıç, Murat Zeytunlu

Journal: Turk. J. Pediatr.. ;55(3):349-53.

 

Crigler-Najjar syndrome type I is an autosomal recessive inherited disease and rarely seen in childhood. Bilirubin neurotoxicity is the morbidity of the disease due to the elevated unconjugated bilirubin levels. Mental retardation, seizures, cognitive dysfunction, oculomotor nerve ...

Last Updated: 12 Nov 2013

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Pregnancy outcome in maternal Crigler-Najjar syndrome type II: a case report and systematic review of the literature.
 

Author(s): V Passuello, A G Puhl, S Wirth, E Steiner, C Skala, H Koelbl, N Kohlschmidt

Journal: Fetal. Diagn. Ther.. 2009 ;26(3):121-6.

 

To report a case of maternal Crigler-Najjar syndrome (CNS) type II in pregnancy, systematically review the literature for similar case reports, and to evaluate whether pregnancy is safe in patients with the disease. Data sources included the PubMed and up to date databases.

Last Updated: 9 Dec 2009

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Liver cell transplantation for Crigler-Najjar syndrome type I: update and perspectives.
 

Author(s): Philippe-A Lysy, Mustapha Najimi, Xavier Stephenne, Annick Bourgois, Francoise Smets, Etienne-M Sokal

Journal: World J. Gastroenterol.. 2008 Jun;14(22):3464-70.

 

Liver cell transplantation is an attractive technique to treat liver-based inborn errors of metabolism. The feasibility and efficacy of the procedure has been demonstrated, leading to medium term partial metabolic control of various diseases. Crigler-Najjar is the paradigm of such ...

Last Updated: 20 Jun 2008

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Immunity Against AAV in Crigler Najjar Patient
 

Status: Recruiting

Condition Summary: Crigler Najjar Syndrome

 

Last Updated: 15 Feb 2016

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Comparison of Biofeedback vs. Botox Injection to Treat Levator Ani Syndrome
 

Status: Recruiting

Condition Summary: Levator Ani Syndrome With Pain and/or Constipation Symptoms.

 

Last Updated: 26 Nov 2007

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Hepatocyte Transplantation for Liver Based Metabolic Disorders
 

Status: Recruiting

Condition Summary: Metabolic Diseases

 

Last Updated: 1 Dec 2015

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