Crigler Najjar Syndrome, Type 1

Common Name(s)

Crigler Najjar Syndrome, Type 1

Crigler Najjar syndrome, type 1 is an inherited disorder in which bilirubin, a substance made by the liver, cannot be broken down. This condition occurs when the enzyme that normally converts bilirubin into a form that can easily be removed from the body does not work correctly. Without this enzyme, bilirubin can build up in the body and lead to jaundice and damage to the brain, muscles, and nerves. Crigler Najjar syndrome, type 1 is caused by mutations in the UGT1A1 gene. The condition is inherited in an autosomal recessive manner. Treatment relies on regular phototherapy throughout life. Blood transfusions and calcium compounds have also been used. Liver transplantation may be considered in some individuals.   
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Crigler Najjar Syndrome, Type 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Long-term Safety Follow-up Study of Patients Having Received Infusions of HepaStem
 

Status: Recruiting

Condition Summary: Urea Cycle Disorders,; Crigler Najjar Syndrome

 

Last Updated: 30 Jan 2014

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Comparison of Biofeedback vs. Botox Injection to Treat Levator Ani Syndrome
 

Status: Recruiting

Condition Summary: Levator Ani Syndrome With Pain and/or Constipation Symptoms.

 

Last Updated: 26 Nov 2007

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