Creutzfeldt-Jakob Disease

Common Name(s)

Creutzfeldt-Jakob Disease, CJD

Creutzfeldt-Jakob disease (CJD) is a rare, degenerative, invariably fatal brain disorder. It affects about one person in every one million people per year worldwide. CJD usually appears in later life and runs a rapid course. Typically, onset of symptoms occurs about age 60, and about 90 percent of patients die within 1 year. In the early stages of disease, patients may have failing memory, behavioral changes, lack of coordination and visual disturbances. As the illness progresses, mental deterioration becomes pronounced and involuntary movements, blindness, weakness of extremities, and coma may occur.

CJD belongs to a family of human and animal diseases known as the transmissible spongiform encephalopathies (TSEs). Spongiform refers to the characteristic appearance of infected brains, which become filled with holes until they resemble sponges under a microscope. CJD is the most common of the known human TSEs. Other human TSEs include kuru, fatal familial insomnia (FFI), and Gerstmann-Straussler-Scheinker disease (GSS).

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Creutzfeldt-Jakob Disease" for support, advocacy or research.

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The CJD Foundation

The Creutzfeldt-Jakob Disease Foundation consists of members who are concerned about the complexity of issues surrounding this fatal brain disease. Our mission is to support families and loved ones touched by CJD.

Last Updated: 11 Mar 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Creutzfeldt-Jakob Disease" for support, advocacy or research.

Logo
The CJD Foundation

The Creutzfeldt-Jakob Disease Foundation consists of members who are concerned about the complexity of issues surrounding this fatal brain disease. Our mission is to support families and loved ones touched by CJD.

http://www.cjdfoundation.org

Last Updated: 11 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Creutzfeldt-Jakob Disease" returned 488 free, full-text research articles on human participants. First 3 results:

Increased interleukin-17 in the cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease: a case-control study of rapidly progressive dementia.
 

Author(s): Koji Fujita, Naoko Matsui, Yukitoshi Takahashi, Yasushi Iwasaki, Mari Yoshida, Tatsuhiko Yuasa, Yuishin Izumi, Ryuji Kaji

Journal:

 

Inflammatory responses in the cerebrospinal fluid (CSF) of patients with sporadic Creutzfeldt-Jakob disease (sCJD) remain elusive.

Last Updated: 9 Dec 2013

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Splice site SNPs of phospholipase PLCXD3 are significantly associated with variant and sporadic Creutzfeldt-Jakob disease.
 

Author(s): Matthew T Bishop, Pascual Sanchez-Juan, Richard S G Knight

Journal:

 

Variant Creutzfeldt-Jakob disease is an infectious, neurodegenerative, protein-misfolding disease, of the prion disease family, originally acquired through ingestion of meat products contaminated with bovine spongiform encephalopathy (BSE). Public health concern was increased by the ...

Last Updated: 15 Nov 2013

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Lack of prion infectivity in fixed heart tissue from patients with Creutzfeldt-Jakob disease or amyloid heart disease.
 

Author(s): Suzette A Priola, Anne E Ward, Sherman A McCall, Matthew Trifilo, Young Pyo Choi, Laura Solforosi, R Anthony Williamson, Justin T Cruite, Michael B A Oldstone

Journal: J. Virol.. 2013 Sep;87(17):9501-10.

 

In most forms of prion disease, infectivity is present primarily in the central nervous system or immune system organs such as spleen and lymph node. However, a transgenic mouse model of prion disease has demonstrated that prion infectivity can also be present as amyloid deposits ...

Last Updated: 14 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Creutzfeldt-Jakob Disease" returned 41 free, full-text review articles on human participants. First 3 results:

Creutzfeldt-Jakob disease: a case report and differential diagnoses.
 

Author(s): Gotaro Kojima, Brent K Tatsuno, Michiko Inaba, Stephanie Velligas, Kamal Masaki, Kore K Liow

Journal: Hawaii J Med Public Health. 2013 Apr;72(4):136-9.

 

Sporadic Creutzfeldt-Jakob disease is a rare neurodegenerative disorder of unknown etiology that causes rapidly progressive dementia. This disease is uniformly fatal and most patients die within 12 months. Clinical findings include myoclonus, visual disturbances, and cerebellar and ...

Last Updated: 24 Jun 2013

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Sensitivity to biases of case-control studies on medical procedures, particularly surgery and blood transfusion, and risk of Creutzfeldt-Jakob disease.
 

Author(s): Jesús de Pedro Cuesta, María Ruiz Tovar, Hester Ward, Miguel Calero, Andrew Smith, Concepción Alonso Verduras, Maurizio Pocchiari, Marc L Turner, Frode Forland, Daniel Palm, Robert G Will

Journal: Neuroepidemiology. 2012 ;39(1):1-18.

 

Evidence of risk of Creutzfeldt-Jakob disease (CJD) associated with medical procedures, including surgery and blood transfusion, is limited by susceptibility to bias in epidemiological studies.

Last Updated: 26 Jul 2012

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Health professions and risk of sporadic Creutzfeldt-Jakob disease, 1965 to 2010.
 

Author(s): E Alcalde-Cabero, J Almazan-Isla, J P Brandel, M Breithaupt, J Catarino, S Collins, J Hayback, R Hoftberger, E Kahana, G G Kovacs, A Ladogana, E Mitrova, A Molesworth, Y Nakamura, M Pocchiari, M Popovic, M Ruiz-Tovar, Al Taratuto, C van Duijn, M Yamada, R G Will, I Zerr, J de Pedro Cuesta

Journal:

 

In 2009, a pathologist with sporadic Creutzfeldt-Jakob Disease (sCJD) was reported to the Spanish registry. This case prompted a request for information on health-related occupation in sCJD cases from countries participating in the European Creutzfeldt Jakob Disease Surveillance network ...

Last Updated: 20 Apr 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Notification of Donors With Positive Microbiology Markers
 

Status: Not yet recruiting

Condition Summary: Human Immunodeficiency Virus; Hepatitis B; Hepatitis C; Human T-lymphotropic Virus I & II; Creutzfeldt-Jakob Syndrome; HIV Infections

 

Last Updated: 12 Feb 2010

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