Cowden-like syndrome

Common Name(s)

Cowden-like syndrome

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cowden-like syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cowden-like syndrome" returned 3 free, full-text research articles on human participants. First 3 results:

Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53.
 

Author(s): Ying Ni, Xin He, Jinlian Chen, Jessica Moline, Jessica Mester, Mohammed S Orloff, Matthew D Ringel, Charis Eng

Journal: Hum. Mol. Genet.. 2012 Jan;21(2):300-10.

 

Cowden syndrome (CS), a Mendelian autosomal-dominant disorder, predisposes to breast, thyroid and other cancers. Germline mutations in phosphatase and tensin homolog (PTEN) have been recently reported in 23% of a large series of classic CS. Here, we validated our small (n = 10) pilot ...

Last Updated: 28 Dec 2011

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Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with Cowden and Cowden-like syndrome characterized by germline PTEN, SDH, or KLLN alterations.
 

Author(s): Joanne Ngeow, Jessica Mester, Lisa A Rybicki, Ying Ni, Mira Milas, Charis Eng

Journal: J. Clin. Endocrinol. Metab.. 2011 Dec;96(12):E2063-71.

 

Thyroid cancer is believed to be an important component of Cowden syndrome (CS). Germline PTEN and SDHx mutations and KLLN epimutation cause CS and CS-like phenotypes. Despite the established association, little is known about the incidence and clinical features of thyroid cancer ...

Last Updated: 6 Dec 2011

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Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome.
 

Author(s): Kristi L Bennett, Jessica Mester, Charis Eng

Journal: JAMA. 2010 Dec;304(24):2724-31.

 

Germline loss-of-function phosphatase and tensin homolog gene (PTEN) mutations cause 80% of Cowden syndrome, a rare autosomal-dominant disorder (1 in 200,000 live births), characterized by high risks of breast, thyroid, and other cancers. A large heterogeneous group of individuals ...

Last Updated: 23 Dec 2010

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cowden-like syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer
 

Status: Recruiting

Condition Summary: Familial Ovarian Cancer; Familial Breast Cancer; BRCA1-associate Malignancies; BRCA2-associated Malignancies

 

Last Updated: 21 Jun 2014

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