Congenital hyperammonemia, type I

Common Name(s)

Congenital hyperammonemia, type I

Carbamoyl phosphate synthetase I deficiency is an autosomal recessive inborn error of metabolism of the urea cycle which causes hyperammonemia. There are 2 main forms: a lethal neonatal type and a less severe, delayed-onset type (summary by {14:Klaus et al., 2009}). Urea cycle disorders are characterized by the triad of hyperammonemia, encephalopathy, and respiratory alkalosis. Five disorders involving different defects in the biosynthesis of the enzymes of the urea cycle have been described: ornithine transcarbamylase deficiency ({311250}), carbamyl phosphate synthetase deficiency, argininosuccinate synthetase deficiency, or citrullinemia ({215700}), argininosuccinate lyase deficiency ({207900}), and arginase deficiency ({207800}).
 

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Condition Specific Organizations

Following organizations serve the condition "Congenital hyperammonemia, type I" for support, advocacy or research.

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Scientific Literature

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