Congenital Stromal Corneal Dystrophy

Common Name(s)

Congenital Stromal Corneal Dystrophy

Congenital stromal corneal dystrophy (CSCD) is a rare autosomal dominant eye disease characterized by diffuse bilateral corneal clouding with flake-like whitish opacities throughout the stroma. These small flakes and spots are present at or shortly after birth and are thought to become more numerous with age. Some affected individuals may have strabismus or nystagmus. Normal corneal thickness, horizontal diameter, and endothelial function distinguish the condition from congenital corneal opacifications such as congenital hereditary endothelial dystrophy (see {121700}), posterior polymorphous dystrophy (see {122000}), and congenital glaucoma (see {137760}). Most individuals undergo a penetrating keratoplasty in late adolescence or in early adulthood with good results (summary by {4:Kim et al., 2011} and {3:Jing et al., 2014}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Congenital Stromal Corneal Dystrophy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Congenital Stromal Corneal Dystrophy" returned 1 free, full-text research articles on human participants. First 3 results:

Decorin accumulation contributes to the stromal opacities found in congenital stromal corneal dystrophy.
 

Author(s): Cecilie Bredrup, Espen Stang, Ove Bruland, Barbara P Palka, Robert D Young, Jan Haavik, Per M Knappskog, Eyvind Rødahl

Journal: Invest. Ophthalmol. Vis. Sci.. 2010 Nov;51(11):5578-82.

 

Congenital stromal corneal dystrophy (CSCD) is characterized by stromal opacities that morphologically are seen as interlamellar layers of amorphous substance with small filaments, the nature of which has hitherto been unknown. CSCD is associated with truncating mutations in the decorin ...

Last Updated: 28 Oct 2010

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Reviews from the PubMed Database

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The terms "Congenital Stromal Corneal Dystrophy" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.