Congenital Heart Defects

Common Name(s)

Congenital Heart Defects, Congenital Heart Disease

Congenital Heart Disease (or Congenital Heart Defects) is one of the most common abnormalities found in newborn babies. Congenital Heart Disease, or CHD, is a problem with the structure of the heart that is present at birth and may present in a wide range - from very mild to critically life threatening in the first days of life. The defects generally cause disruptions in the normal blood flow or rhythm of the heart. Defects can be associated with the chambers or valves of the heart or the arteries or veins near the heart. Critical Congenital Heart Disease (CCHD) defines more severe forms of CHD that can lead to death soon after the baby is born. CCHD happens when a baby’s heart does not develop normally before birth. Although it is rare, affecting only 2-3 of every 10,000 babies born, CCHD can quickly lead to serious illness and even death in the first few days of life. Some babies with CCHD are discovered early in pregnancy by prenatal ultrasound, but many babies with CCHD are diagnosed after they are born. Unfortunately, many of these babies can appear perfectly normal until they become critically ill.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Congenital Heart Defects" for support, advocacy or research.

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Congenital Heart Information Network

C.H.I.N. is a national organization that provides reliable information, advocacy, support services, financial assistance and resources to families of children with congenital heart defects and acquired heart disease, and adults with congenital heart defects.

http://tchin.org

Last Updated: 12 Oct 2013

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It's My Heart, Inc.

It's My Heart's mission is to provide support, spread awareness, educate and advocate for those affected by congenital heart defects by creating alliances with fellow families, hospitals, support groups, and the community.

http://www.itsmyheart.org

Last Updated: 10 Jan 2013

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Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 30 Oct 2012

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Mended Hearts, Inc.

Our mission is dedicated to “Inspiring hope and improving the quality of life for heart patients and their families through ongoing peer-to-peer support”.

http://www.mendedhearts.org

Last Updated: 11 Mar 2013

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Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

http://www.savinglittlehearts.com

Last Updated: 15 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Congenital Heart Defects" for support, advocacy or research.

Logo
Congenital Heart Information Network

C.H.I.N. is a national organization that provides reliable information, advocacy, support services, financial assistance and resources to families of children with congenital heart defects and acquired heart disease, and adults with congenital heart defects.

http://tchin.org

Last Updated: 12 Oct 2013

View Details
It's My Heart, Inc.

It's My Heart's mission is to provide support, spread awareness, educate and advocate for those affected by congenital heart defects by creating alliances with fellow families, hospitals, support groups, and the community.

http://www.itsmyheart.org

Last Updated: 10 Jan 2013

View Details
Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 30 Oct 2012

View Details
Logo
Mended Hearts, Inc.

Our mission is dedicated to “Inspiring hope and improving the quality of life for heart patients and their families through ongoing peer-to-peer support”.

http://www.mendedhearts.org

Last Updated: 11 Mar 2013

View Details
Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

http://www.savinglittlehearts.com

Last Updated: 15 Mar 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Congenital Heart Defects" returned 206 free, full-text research articles on human participants. First 3 results:

Public health science agenda for congenital heart defects: report from a Centers for Disease Control and Prevention experts meeting.
 

Author(s): Matthew E Oster, Tiffany Riehle-Colarusso, Regina M Simeone, Michelle Gurvitz, Jonathan R Kaltman, Michael McConnell, Geoffrey L Rosenthal, Margaret A Honein

Journal:

 

Last Updated: 29 Aug 2013

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Increased risk for congenital heart defects in children carrying the ABCB1 Gene C3435T polymorphism and maternal periconceptional toxicants exposure.
 

Author(s): Chuan Wang, Liang Xie, Kaiyu Zhou, Yalan Zhan, Yifei Li, Huaying Li, Lina Qiao, Fang Wang, Yimin Hua

Journal:

 

The etiology of congenital heart defect (CHD) is commonly believed to involve the interaction of multiple environmental and genetic factors. This study aimed to explore the joint effects of the ABCB1 gene C3435T polymorphism and maternal periconceptional toxicants exposure on the ...

Last Updated: 22 Jul 2013

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The complex SNP and CNV genetic architecture of the increased risk of congenital heart defects in Down syndrome.
 

Author(s): M Reza Sailani, Periklis Makrythanasis, Armand Valsesia, Federico A Santoni, Samuel Deutsch, Konstantin Popadin, Christelle Borel, Eugenia Migliavacca, Andrew J Sharp, Genevieve Duriaux Sail, Emilie Falconnet, Kelly Rabionet, Clara Serra-Juhé, Stefano Vicari, Daniela Laux, Yann Grattau, Guy Dembour, Andre Megarbane, Renaud Touraine, Samantha Stora, Sofia Kitsiou, Helena Fryssira, Chariklia Chatzisevastou-Loukidou, Emmanouel Kanavakis, Giuseppe Merla, Damien Bonnet, Luis A Pérez-Jurado, Xavier Estivill, Jean M Delabar, Stylianos E Antonarakis

Journal: Genome Res.. 2013 Sep;23(9):1410-21.

 

Congenital heart defect (CHD) occurs in 40% of Down syndrome (DS) cases. While carrying three copies of chromosome 21 increases the risk for CHD, trisomy 21 itself is not sufficient to cause CHD. Thus, additional genetic variation and/or environmental factors could contribute to the ...

Last Updated: 2 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Congenital Heart Defects" returned 24 free, full-text review articles on human participants. First 3 results:

Nuchal translucency and major congenital heart defects in fetuses with normal karyotype: a meta-analysis.
 

Author(s): A Sotiriadis, S Papatheodorou, M Eleftheriades, G Makrydimas

Journal: Ultrasound Obstet Gynecol. 2013 Oct;42(4):383-9.

 

To pool published data regarding the sensitivity and specificity of nuchal translucency (NT) in the diagnosis of major congenital heart defects (CHDs) in fetuses with normal karyotype.

Last Updated: 30 Sep 2013

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Anterolateral minithoracotomy versus median sternotomy for the treatment of congenital heart defects: a meta-analysis and systematic review.
 

Author(s): Chao Ding, Chunmao Wang, Aiqiang Dong, Minjian Kong, Daming Jiang, Kaiyu Tao, Zhonghua Shen

Journal:

 

Anterolateral Minithoracotomy (ALMT) for the radical correction of Congenital Heart Defects is an alternative to Median Sternotomy (MS) due to reduce operative trauma accelerating recovery and yield a better cosmetic outcome after surgery. Our purpose is to conduct whether ALMT would ...

Last Updated: 13 Sep 2012

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A decade of advances in the molecular embryology and genetics underlying congenital heart defects.
 

Author(s): Kazuki Kodo, Hiroyuki Yamagishi

Journal: Circ. J.. 2011 ;75(10):2296-304.

 

Congenital heart defects (CHD) are the most common type of human birth defect and result in significant mortality worldwide. Despite numerous epidemiologic studies in the past decades, few genetic causes have been identified until recently. CHD result from abnormal morphogenesis of ...

Last Updated: 22 Sep 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Molecular Basis of Congenital Heart Defects
 

Status: Recruiting

Condition Summary: Congenital Heart Defects

 

Last Updated: 5 Nov 2010

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Intestinal Function in Neonates With Complex Congenital Heart Disease
 

Status: Recruiting

Condition Summary: Congenital Heart Defects; Growth Failure

 

Last Updated: 21 May 2013

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An Evaluation of Routine Developmental Follow-Up in Infants and Children With Congenital Heart Disease
 

Status: Recruiting

Condition Summary: Congenital Heart Defects

 

Last Updated: 31 Jul 2013

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