Chronic Infantile Neurological Cutaneous Articular Syndrome

Common Name(s)

Chronic Infantile Neurological Cutaneous Articular Syndrome, CINCA, Infantile multisystem inflammatory disease, NOMID

Chronic infantile neurologic cutaneous and articular (CINCA) syndrome, also known as 'neonatal onset multisystem inflammatory disease,' or NOMID, is a congenital inflammatory disorder characterized by a triad of neonatal onset of cutaneous symptoms (skin rash), chronic meningitis, and joint pain with recurrent fever and inflammation.  CINCA is the most severe form of the cryopyrin associated periodic syndromes (CAPS) caused by mutations in the CIAS1/NLRP3 gene. About 50% of affected individuals have mutations in this gene. This condition is inherited in an autosomal dominant fashion.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Infantile Neurological Cutaneous Articular Syndrome" for support, advocacy or research.

The NOMID Alliance

The NOMID Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases.

http://www.nomidalliance.org

Last Updated: 16 Aug 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Infantile Neurological Cutaneous Articular Syndrome" for support, advocacy or research.

The NOMID Alliance

The NOMID Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases.

http://www.nomidalliance.org

Last Updated: 16 Aug 2013

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General Resources

Comparison Chart of Systemic Autoinflammatory DIseases

This comparative chart of Autoinflammatory Diseases lists symptoms, lab findings, genetic mutations and images for each disease.

Uploaded By: The NOMID Alliance

Updated 15 Aug 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chronic Infantile Neurological Cutaneous Articular Syndrome" returned 2 free, full-text research articles on human participants. First 3 results:

Dramatic improvement with anakinra in a case of chronic infantile neurological cutaneous and articular (CINCA) syndrome.
 

Author(s): B Granel, J Serratrice, P Disdier, P-J Weiller

Journal: Rheumatology (Oxford). 2005 May;44(5):689-90.

 

Last Updated: 20 Apr 2005

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Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes.
 

Author(s): Jérôme Feldmann, Anne-Marie Prieur, Pierre Quartier, Patrick Berquin, Stephanie Certain, Elisabetta Cortis, Dominique Teillac-Hamel, Alain Fischer, Genevieve de Saint Basile

Journal: Am. J. Hum. Genet.. 2002 Jul;71(1):198-203.

 

Chronic infantile neurological cutaneous and articular (CINCA) syndrome is a severe chronic inflammatory disease of early onset, characterized by cutaneous symptoms, central-nervous-system involvement, and arthropathy. In the present study, we report, in seven unrelated patients with ...

Last Updated: 17 Jun 2002

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chronic Infantile Neurological Cutaneous Articular Syndrome" returned 0 free, full-text review articles on human participants.

 
 
 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease
 

Status: Recruiting

Condition Summary: Cryopyrin-associated Periodic Syndromes; Familial Cold Autoinflammatory Syndrome; Muckle-Wells Syndrome; Neonatal Onset Multisystem Inflammatory Disease

 

Last Updated: 12 Oct 2013

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Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease
 

Status: Recruiting

Condition Summary: Cryopyrin-associated Periodic Syndromes; Familial Cold Autoinflammatory Syndrome; Muckle-Wells Syndrome; Neonatal Onset Multisystem Inflammatory Disease

 

Last Updated: 6 Mar 2014

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Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease
 

Status: Recruiting

Condition Summary: Nervous System Malformations; Arthropathy, Neurogenic; Urticaria; Papilledema

 

Last Updated: 14 Mar 2014

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