Neonatal onset multisystem inflammatory disease

Common Name(s)

Neonatal onset multisystem inflammatory disease, Chronic infantile neurological cutaneous articular syndrome, CINCA, Infantile multisystem inflammatory disease, NOMID

Chronic infantile neurologic cutaneous and articular (CINCA) syndrome, also known as 'neonatal onset multisystem inflammatory disease,' or NOMID, is a congenital inflammatory disorder characterized by a triad of neonatal onset of cutaneous symptoms (skin rash), chronic meningitis, and joint pain with recurrent fever and inflammation.  CINCA is the most severe form of the cryopyrin associated periodic syndromes (CAPS) caused by mutations in the CIAS1/NLRP3 gene. About 50% of affected individuals have mutations in this gene. This condition is inherited in an autosomal dominant fashion.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neonatal onset multisystem inflammatory disease" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

Last Updated: 24 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neonatal onset multisystem inflammatory disease" for support, advocacy or research.

Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

http://www.autoinflammatory.org

Last Updated: 24 Jul 2015

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General Support Organizations

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General Resources

Comparison Chart of Systemic Autoinflammatory DIseases

This comparative chart of Autoinflammatory Diseases lists symptoms, lab findings, genetic mutations and images for each disease.

Updated 15 Aug 2013

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Healthier Ever After (injection tips book & program)

This child-friendly book is for patients and their families to learn how to manage their injectable medications, and has a program to help children to discuss and make a plan of care, and goals with rewards to chart on a reusable white board page.

Updated 6 May 2015

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Arts and Literature

CAPS medical guidebook.

Medical guidebook about Cryopyrin-Associated Periodic syndromes (CAPS).

Updated 6 May 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neonatal onset multisystem inflammatory disease" returned 13 free, full-text research articles on human participants. First 3 results:

Enhanced chondrogenesis of induced pluripotent stem cells from patients with neonatal-onset multisystem inflammatory disease occurs via the caspase 1-independent cAMP/protein kinase A/CREB pathway.
 

Author(s): Koji Yokoyama, Makoto Ikeya, Katsutsugu Umeda, Hirotsugu Oda, Seishiro Nodomi, Akira Nasu, Yoshihisa Matsumoto, Kazushi Izawa, Kazuhiko Horigome, Toshimasa Kusaka, Takayuki Tanaka, Megumu K Saito, Takahiro Yasumi, Ryuta Nishikomori, Osamu Ohara, Naoki Nakayama, Tatsutoshi Nakahata, Toshio Heike, Junya Toguchida

Journal: Arthritis Rheumatol. 2015 Jan;67(1):302-14.

 

Neonatal-onset multisystem inflammatory disease (NOMID) is a dominantly inherited autoinflammatory disease caused by NLRP3 mutations. NOMID pathophysiology is explained by the NLRP3 inflammasome, which produces interleukin-1β (IL-1β). However, epiphyseal overgrowth in NOMID is resistant ...

Last Updated: 30 Dec 2014

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A 24-month open-label study of canakinumab in neonatal-onset multisystem inflammatory disease.
 

Author(s): Cailin H Sibley, Andrea Chioato, Sandra Felix, Laurence Colin, Abhijit Chakraborty, Nikki Plass, Jackeline Rodriguez-Smith, Carmen Brewer, Kelly King, Christopher Zalewski, H Jeffrey Kim, Rachel Bishop, Ken Abrams, Deborah Stone, Dawn Chapelle, Bahar Kost, Christopher Snyder, John A Butman, Robert Wesley, Raphaela Goldbach-Mansky

Journal: Ann. Rheum. Dis.. 2015 Sep;74(9):1714-9.

 

To study efficacy and safety of escalating doses of canakinumab, a fully human anti-IL-1β monoclonal antibody in the severe cryopyrin-associated periodic syndrome, neonatal-onset multisystem inflammatory disease (NOMID).

Last Updated: 11 Aug 2015

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Last Updated: 8 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neonatal onset multisystem inflammatory disease" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.