Chronic Granulomatous Disease

Common Name(s)

Chronic Granulomatous Disease

Chronic granulomatous disease (CGD) is a rare, inherited, primary immune deficiency disorder that affects certain white blood cells. It is characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. Symptoms usually begin in infancy or childhood and include life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, and bones; swollen areas of inflamed tissues known as granulomas; and other symptoms. It is caused by mutations in any one of four different genes and is usually inherited in an autosomal recessive or X-linked recessive manner. Treatment consists of continuous antibiotic therapy to help prevent infections and corticosteroid drugs for treating granulomatous complications.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Granulomatous Disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition is dedicated to building relationships with charitable organizations founded to help individuals and families affected by serious chronic disorders and diseases.

http://www.caringvoice.org

Last Updated: 1 Mar 2013

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Chronic Granulomatous Disease Association, Inc.

The Chronic Granulomatous Disease Association is an international support group for patients with CGD. We have a database of over 1,000 patients. Also, we have physician referrals, link CGD patients in close geographical proximity or with similar illnesses; a medical ref. library & many resources that CGD patients & parents are concerned about. We give grants for CGD research. Our website is www.cgdassociation.org cgda@socal.rr.com

http://www.cgdassociation.org

Last Updated: 11 Feb 2013

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Chronic Granulomatous Disorder Society

The CGD Society is the leading source of support for individuals and families affected by chronic granulomatous disorder in the UK. The charity: - provides comprehensive information on chronic granulomatous disorder in the form of a website and publications - offers direct support to individuals and families via email and a helpline - funds a nursing support service that assists both patients and medical professionals requiring advice on the treatment of a patient affected by CGD

http://www.cgdsociety.org

Last Updated: 15 Apr 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Granulomatous Disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition is dedicated to building relationships with charitable organizations founded to help individuals and families affected by serious chronic disorders and diseases.

http://www.caringvoice.org

Last Updated: 1 Mar 2013

View Details
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Chronic Granulomatous Disease Association, Inc.

The Chronic Granulomatous Disease Association is an international support group for patients with CGD. We have a database of over 1,000 patients. Also, we have physician referrals, link CGD patients in close geographical proximity or with similar illnesses; a medical ref. library & many resources that CGD patients & parents are concerned about. We give grants for CGD research. Our website is www.cgdassociation.org cgda@socal.rr.com

http://www.cgdassociation.org

Last Updated: 11 Feb 2013

View Details
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Chronic Granulomatous Disorder Society

The CGD Society is the leading source of support for individuals and families affected by chronic granulomatous disorder in the UK. The charity: - provides comprehensive information on chronic granulomatous disorder in the form of a website and publications - offers direct support to individuals and families via email and a helpline - funds a nursing support service that assists both patients and medical professionals requiring advice on the treatment of a patient affected by CGD

http://www.cgdsociety.org

Last Updated: 15 Apr 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chronic Granulomatous Disease" returned 350 free, full-text research articles on human participants. First 3 results:

X-linked chronic granulomatous disease in a male child with an X-CGD carrier, Klinefelter brother.
 

Author(s): Harvindar Kaur Gill, Hemahwathy Chanthira Kumar, Chan Kwai Cheng, Choo Chong Ming, Revathy Nallusamy, Narazah Mohd Yusoff, Saharuddin B Mohamad, Adiratna Mat Ripen, Jasbir Singh Dhaliwal, Shahnaz Murad

Journal: Asian Pac. J. Allergy Immunol.. 2013 Jun;31(2):167-72.

 

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency (PID) caused by a dysfunctional respiratory burst enzyme NADPH-oxidase. The concurrence of Klinefelter's Syndrome (KS) and CGD would be extremely rare.

Last Updated: 17 Jul 2013

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Chronic granulomatous disease caused by a novel mutation in a 2-month-old boy with multifocal splenic abscesses.
 

Author(s): M Jesenak, Z Havlicekova, P Banovcin, M J Stasia

Journal: J Investig Allergol Clin Immunol. 2013 ;23(2):137-8.

 

Last Updated: 9 May 2013

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Chronic granulomatous disease with gastrointestinal presentation: diagnostic pitfalls and novel ultrastructural findings.
 

Author(s): M I Spagnuolo, G Russo, G Giardino, M A Caiazzo, E Cirillo, G Ranucci, A Guarino, B Martire, R Vecchione, G Di Matteo, D Postorivo, C Pignata

Journal: J Investig Allergol Clin Immunol. 2012 ;22(7):527-9.

 

Last Updated: 12 Feb 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chronic Granulomatous Disease" returned 24 free, full-text review articles on human participants. First 3 results:

Chronic granulomatous disease.
 

Author(s): Steven M Holland

Journal: Hematol. Oncol. Clin. North Am.. 2013 Feb;27(1):89-99, viii.

 

Chronic granulomatous disease (CGD) is a paradigm for nonlymphoid primary immune defects, and has guided elucidation of oxygen metabolism in the phagocyte, vasculature, and brain. It has been in the forefront of the development of antimicrobial prophylaxis before the advent of advanced ...

Last Updated: 28 Jan 2013

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Aspergillus nidulans and chronic granulomatous disease: a unique host-pathogen interaction.
 

Author(s): Stefanie S V Henriet, Paul E Verweij, Adilia Warris

Journal: J. Infect. Dis.. 2012 Oct;206(7):1128-37.

 

Invasive fungal infections are a major threat for patients suffering from chronic granulomatous disease (CGD), a primary immunodeficiency caused by a defect in the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase. Interestingly, Aspergillus (Emericella) nidulans is the ...

Last Updated: 7 Sep 2012

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Prostatic abscess in a pediatric patient with chronic granulomatous disease: report of a unique case and review of the literature.
 

Author(s): Nnenaya Q Agochukwu, Ardeshir R Rastinehad, Lee A Richter, Stephanie Barak, Christa S Zerbe, Steven M Holland, Peter A Pinto

Journal: J. Pediatr. Surg.. 2012 Feb;47(2):400-3.

 

Chronic granulomatous disease (CGD) is a rare hereditary disease in which phagocytes have difficulty forming the superoxide radical required to kill certain pathogens. Individuals with CGD are susceptible to a specific set of infections and granulomatous lesions. We present the case ...

Last Updated: 13 Feb 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Matched Unrelated or Non-Genotype Identical Related Donor Transplantation For Chronic Granulomatous Disease
 

Status: Recruiting

Condition Summary: Chronic Granulomatous Disease

 

Last Updated: 12 Mar 2014

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Radiofrequency Ablation for Liver Abscesses From Chronic Granulomatous Disease
 

Status: Recruiting

Condition Summary: Radiofrequency Ablation; Liver Abscesses -Staphylococcus Infection; CGD; Chronic Granulomatous Disease; RFA

 

Last Updated: 14 Mar 2014

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Assessment of the Biochemical Response to Interferon-Gamma in Subjects With Specific Gene Mutation in Chronic Granulomatous Disease
 

Status: Recruiting

Condition Summary: IFN-Gamma Therapy; CGD Gene Mutation; CGD Response to IFNg; Chronic Granulomatous Disease; Immunodeficiency Disease

 

Last Updated: 14 Mar 2014

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