Chronic Granulomatous Disease

Common Name(s)

Chronic Granulomatous Disease

Chronic granulomatous disease (CGD) is a rare, inherited, primary immune deficiency disorder that affects certain white blood cells. It is characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. Symptoms usually begin in infancy or childhood and include life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, and bones; swollen areas of inflamed tissues known as granulomas; and other symptoms. It is caused by mutations in any one of four different genes and is usually inherited in an autosomal recessive or X-linked recessive manner. Treatment consists of continuous antibiotic therapy to help prevent infections and corticosteroid drugs for treating granulomatous complications.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Granulomatous Disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

Last Updated: 29 Apr 2014

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Chronic Granulomatous Disease Association, Inc.

The Chronic Granulomatous Disease Association is an international support group for patients with CGD. We have a database of over 1,000 patients. Also, we have physician referrals, link CGD patients in close geographical proximity or with similar illnesses; a medical ref. library & many resources that CGD patients & parents are concerned about. We give grants for CGD research. Our website is www.cgdassociation.org cgda@socal.rr.com

Last Updated: 11 Feb 2013

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Chronic Granulomatous Disorder Society

The CGD Society is the leading source of support for individuals and families affected by chronic granulomatous disorder in the UK. The charity: - provides comprehensive information on chronic granulomatous disorder in the form of a website and publications - offers direct support to individuals and families via email and a helpline - funds a nursing support service that assists both patients and medical professionals requiring advice on the treatment of a patient affected by CGD

Last Updated: 15 Apr 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Granulomatous Disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

http://www.caringvoice.org

Last Updated: 29 Apr 2014

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Chronic Granulomatous Disease Association, Inc.

The Chronic Granulomatous Disease Association is an international support group for patients with CGD. We have a database of over 1,000 patients. Also, we have physician referrals, link CGD patients in close geographical proximity or with similar illnesses; a medical ref. library & many resources that CGD patients & parents are concerned about. We give grants for CGD research. Our website is www.cgdassociation.org cgda@socal.rr.com

http://www.cgdassociation.org

Last Updated: 11 Feb 2013

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Chronic Granulomatous Disorder Society

The CGD Society is the leading source of support for individuals and families affected by chronic granulomatous disorder in the UK. The charity: - provides comprehensive information on chronic granulomatous disorder in the form of a website and publications - offers direct support to individuals and families via email and a helpline - funds a nursing support service that assists both patients and medical professionals requiring advice on the treatment of a patient affected by CGD

http://www.cgdsociety.org

Last Updated: 15 Apr 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chronic Granulomatous Disease" returned 377 free, full-text research articles on human participants. First 3 results:

Chronic granulomatous disease presenting with ecthyma gangrenosum in a neonate.
 

Author(s): Brea Prindaville, Amy J Nopper, Hillary Lawrence, Kimberly A Horii

Journal: J. Am. Acad. Dermatol.. 2014 Aug;71(2):e44-5.

 

Last Updated: 19 Jul 2014

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Altered pattern of Naïve and memory B cells and B1 cells in patients with chronic granulomatous disease.
 

Author(s): Monireh Mohsenzadegan, Fahimeh Fattahi, Fatemeh Fattahi, Abbas Mirshafiey, Mohammad Reza Fazlollahi, Fariba Naderi Beni, Masoud Movahedi, Zahra Pourpak

Journal: Iran J Allergy Asthma Immunol. 2014 Jun;13(3):157-65.

 

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder characterized by a greatly increased susceptibility to severe fungal and bacterial infections caused by defects in NADPH oxidase of phagocytic cells. We aimed to investigate immunophenotype alterations ...

Last Updated: 24 Mar 2014

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IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans.
 

Author(s): Antonella de Luca, Sanne P Smeekens, Andrea Casagrande, Rossana Iannitti, Kara L Conway, Mark S Gresnigt, Jakob Begun, Theo S Plantinga, Leo A B Joosten, Jos W M van der Meer, Georgios Chamilos, Mihai G Netea, Ramnik J Xavier, Charles A Dinarello, Luigina Romani, Frank L van de Veerdonk

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Mar;111(9):3526-31.

 

Patients with chronic granulomatous disease (CGD) have a mutated NADPH complex resulting in defective production of reactive oxygen species; these patients can develop severe colitis and are highly susceptible to invasive fungal infection. In NADPH oxidase-deficient mice, autophagy ...

Last Updated: 5 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chronic Granulomatous Disease" returned 25 free, full-text review articles on human participants. First 3 results:

Chronic granulomatous disease.
 

Author(s): Steven M Holland

Journal: Hematol. Oncol. Clin. North Am.. 2013 Feb;27(1):89-99, viii.

 

Chronic granulomatous disease (CGD) is a paradigm for nonlymphoid primary immune defects, and has guided elucidation of oxygen metabolism in the phagocyte, vasculature, and brain. It has been in the forefront of the development of antimicrobial prophylaxis before the advent of advanced ...

Last Updated: 28 Jan 2013

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[Chronic granulomatous disease: pathogenesis and therapy of associated fungal infections].
 

Author(s): Anne Desjardins, Hélène Coignard-Biehler, Nizar Mahlaoui, Pierre Frange, Marie-Elisabeth Bougnoux, Stéphane Blanche, Alain Fischer, Sophie Blumental, Olivier Lortholary

Journal: Med Sci (Paris). 2012 Nov;28(11):963-9.

 

Chronic granulomatous disease is a genetic disorder responsible for a defect in the NADPH oxidase of phagocytic cells. It impairs the oxidative burst necessary to the intracellular inactivation of microorganisms and predisposes to an increased risk of infections by various microorganisms, ...

Last Updated: 22 Nov 2012

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Aspergillus nidulans and chronic granulomatous disease: a unique host-pathogen interaction.
 

Author(s): Stefanie S V Henriet, Paul E Verweij, Adilia Warris

Journal: J. Infect. Dis.. 2012 Oct;206(7):1128-37.

 

Invasive fungal infections are a major threat for patients suffering from chronic granulomatous disease (CGD), a primary immunodeficiency caused by a defect in the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase. Interestingly, Aspergillus (Emericella) nidulans is the ...

Last Updated: 7 Sep 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Matched Unrelated or Non-Genotype Identical Related Donor Transplantation For Chronic Granulomatous Disease
 

Status: Recruiting

Condition Summary: Chronic Granulomatous Disease

 

Last Updated: 9 Sep 2014

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Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995
 

Status: Not yet recruiting

Condition Summary: Chronic Granulomatous Disease

 

Last Updated: 15 Apr 2014

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Haploidentical Transplant for People With Chronic Granulomatous Disease Using Post Transplant Cyclophosphamide
 

Status: Recruiting

Condition Summary: Chronic Granulomatous Disease

 

Last Updated: 25 Dec 2014

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