Chronic Granulomatous Disease

Common Name(s)

Chronic Granulomatous Disease

Chronic granulomatous disease (CGD) is a rare, inherited, primary immune deficiency disorder that affects certain white blood cells. It is characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. Symptoms usually begin in infancy or childhood and include life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, and bones; swollen areas of inflamed tissues known as granulomas; and other symptoms. It is caused by mutations in any one of four different genes and is usually inherited in an autosomal recessive or X-linked recessive manner. Treatment consists of continuous antibiotic therapy to help prevent infections and corticosteroid drugs for treating granulomatous complications.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Granulomatous Disease" for support, advocacy or research.

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Chronic Granulomatous Disease Association, Inc.

The Chronic Granulomatous Disease Association is an international support group for patients with CGD. We have a database of over 1,000 patients. Also, we have physician referrals, link CGD patients in close geographical proximity or with similar illnesses; a medical ref. library & many resources that CGD patients & parents are concerned about. We give grants for CGD research. Our website is www.cgdassociation.org cgda@socal.rr.com

Last Updated: 11 Feb 2013

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Chronic Granulomatous Disorder Society

The CGD Society is the leading source of support for individuals and families affected by chronic granulomatous disorder in the UK. The charity: - provides comprehensive information on chronic granulomatous disorder in the form of a website and publications - offers direct support to individuals and families via email and a helpline - funds a nursing support service that assists both patients and medical professionals requiring advice on the treatment of a patient affected by CGD

Last Updated: 15 Apr 2013

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Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

Last Updated: 27 Aug 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Granulomatous Disease" for support, advocacy or research.

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Chronic Granulomatous Disease Association, Inc.

The Chronic Granulomatous Disease Association is an international support group for patients with CGD. We have a database of over 1,000 patients. Also, we have physician referrals, link CGD patients in close geographical proximity or with similar illnesses; a medical ref. library & many resources that CGD patients & parents are concerned about. We give grants for CGD research. Our website is www.cgdassociation.org cgda@socal.rr.com

http://www.cgdassociation.org

Last Updated: 11 Feb 2013

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Chronic Granulomatous Disorder Society

The CGD Society is the leading source of support for individuals and families affected by chronic granulomatous disorder in the UK. The charity: - provides comprehensive information on chronic granulomatous disorder in the form of a website and publications - offers direct support to individuals and families via email and a helpline - funds a nursing support service that assists both patients and medical professionals requiring advice on the treatment of a patient affected by CGD

http://www.cgdsociety.org

Last Updated: 15 Apr 2013

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Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

http://www.primaryimmune.org

Last Updated: 27 Aug 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chronic Granulomatous Disease" returned 410 free, full-text research articles on human participants. First 3 results:

[Pulmonary infection by Arthrographis kalrae in patient with chronic granulomatous disease].
 

Author(s): Christian J Campoverde Espinoza, Carolina M Carballo, M Nancy Orlando, Alejandra I Hevia, Andrea C Gómez Raccio, Daniela Di Giovanni, Liliana Bezrodnik, Miryam S Vázquez Orlando, Claudia I Cazes, Eduardo L López

Journal: Arch Argent Pediatr. 2017 Dec;115(6):e458-e461.

 

Arthrographis kalrae is a hyaline fungus that grows forming arthroconidia. It is an opportunistic pathogen that causes infections in immunocompromised as in immunocompetent people and has been rarely isolated from human clinical samples.

Last Updated: 31 Dec 1969

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Mimicking hypersensitivity pneumonitis as an uncommon initial presentation of chronic granulomatous disease in children.
 

Author(s): Hui Liu, Jinrong Liu, Huimin Li, Yun Peng, Shunying Zhao

Journal:

 

Dry cough, dyspenea and diffuse centrilobular nodules in both lungs of radiologic findings similar to hypersensitivity pneumonitis (HP) are rare initial presentation in chronic granulomatous disease (CGD). CGD is remarkable for increased susceptibility to bacterial and fungal infections ...

Last Updated: 31 Dec 1969

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A rare complication of chronic granulomatous disease in a child: constrictive aspergillus pericarditis.
 

Author(s): Emrah Şişli, Yasemin Özdemir Şahan, Mehmet Fatih Ayık, Deniz Nart, Yüksel Atay

Journal: Turk Kardiyol Dern Ars. 2017 Oct;45(7):660-663.

 

A 3-year-old girl with the diagnosis of chronic granulomatous disease (CGD) was hospitalized for bronchopneumonia and congestive heart failure. Her medical history included methylprednisolone medication for autoimmune gastric outlet obstruction. Computed tomography revealed pneumonic ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chronic Granulomatous Disease" returned 43 free, full-text review articles on human participants. First 3 results:

Prevention of Infectious Complications in Patients With Chronic Granulomatous Disease.
 

Author(s): Maria A Slack, Isaac P Thomsen

Journal: J Pediatric Infect Dis Soc. 2018 May;7(suppl_1):S25-S30.

 

Chronic granulomatous disease (CGD) is a primary immunodeficiency that confers a markedly increased risk of bacterial and fungal infections caused by certain opportunistic pathogens. Current evidence supports the use of prophylactic antibacterial, antifungal, and immunomodulatory ...

Last Updated: 31 Dec 1969

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Allogeneic Hematopoietic Cell Transplantation for Chronic Granulomatous Disease: Controversies and State of the Art.
 

Author(s): James A Connelly, Rebecca Marsh, Suhag Parikh, Julie-An Talano

Journal: J Pediatric Infect Dis Soc. 2018 May;7(suppl_1):S31-S39.

 

Chronic granulomatous disease (CGD) is a congenital disorder characterized by recurrent life-threatening bacterial and fungal infections and development of severe inflammation secondary to a congenital defect in 1 of the 5 phagocyte oxidase (phox) subunits of the nicotinamide adenine ...

Last Updated: 31 Dec 1969

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Noninfectious Manifestations and Complications of Chronic Granulomatous Disease.
 

Author(s): Sarah E Henrickson, Artemio M Jongco, Kelly F Thomsen, Elizabeth K Garabedian, Isaac P Thomsen

Journal: J Pediatric Infect Dis Soc. 2018 May;7(suppl_1):S18-S24.

 

Chronic granulomatous disease (CGD), a primary immunodeficiency characterized by a deficient neutrophil oxidative burst and the inadequate killing of microbes, is well known to cause a significantly increased risk of invasive infection. However, infectious complications are not the ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pioglitazone Therapy for Chronic Granulomatous Disease
 

Status: Recruiting

Condition Summary: Chronic Granulomatous Disease

 

Last Updated: 16 Nov 2017

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Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995
 

Status: Recruiting

Condition Summary: Chronic Granulomatous Disease

 

Last Updated: 1 Nov 2018

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