Celiac disease

Common Name(s)

Celiac disease, Celiac sprue

Celiac disease is an autoimmune response to gluten that causes damage to the lining of the gastrointestinal tract (stomach and intestines). Gluten is a protein found in wheat, rye and barley. When an individual with celiac disease eats gluten-containing foods, their immune system overreacts and causes swelling, inflammation and damage of the small intestines. This damage leads to poor absorption of nutrients from food, weight loss, bloating, and diarrhea. Other symptoms include iron deficiency that results in a low number of red blood cells (anemia), vitamin deficiencies, low bone mineral density (osteoporosis), itchy skin rashes, defects in the enamel of the teeth, chronic fatigue, joint pain, poor growth, delayed puberty, infertility, or repeated miscarriages. Neurological problems have also been associated with celiac disease and include migraine headaches, depression, attention deficit hyperactivity disorder (ADHD), and recurrent seizures (epilepsy). The exact cause of celiac disease is unknown. However, certain variants within the HLA-DQA1 and HLA-DQB1 genes, which play a role in the immune system, can increase a person’s risk for celiac disease. Infections, surgery, childbirth, and severe emotional stress can all trigger this condition.

In order to diagnose celiac disease, a doctor may need to conduct a biopsy (removal of tissue) of the small intestine. A detailed medical history, a physical examination, and blood tests may also be needed to diagnose this condition. Treatment involves the removal of gluten-containing foods from the diet. Your doctor may also recommend specific vitamin and mineral supplements to ensure you are receiving proper nutrients. Medication is also available to treat damage that may have occurred in the small intestines. Talk with your doctor to decide which treatment option is best for you. Support groups are also good resources for additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Celiac disease" for support, advocacy or research.

Coeliac Society of Ireland

The mission of the Coeliac Society of Ireland is to improve the quality of life for Coeliacs and others who benefit from a gluten-free diet for medical reasons.

Last Updated: 1 May 2015

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Gluten Intolerance Group

The mission of the Gluten Intolerance Group of North America® is to support persons with gluten intolerances, celiac disease, dermatitis herpetiformis, and other gluten sensitivities, through consumer and industry services and programs that positively promote healthy lives.

Last Updated: 10 Mar 2015

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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Celiac Disease Foundation

Celiac Disease Foundation drives diagnosis, treatment, and a cure for celiac disease through advocacy, education, and research to improve the quality of life for all people affected by gluten-related disorders.

Last Updated: 26 May 2016

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National Foundation for Celiac Awareness

The National Foundation for Celiac Awareness advances widespread understanding of celiac disease as a serious genetic autoimmune condition and works to secure early diagnosis and effective management. We empower our community to live life to the fullest, and serve as a leading and trusted resource that inspires hope, accelerates innovation and forges pathways to a cure.

Last Updated: 19 May 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Celiac disease" for support, advocacy or research.

Coeliac Society of Ireland

The mission of the Coeliac Society of Ireland is to improve the quality of life for Coeliacs and others who benefit from a gluten-free diet for medical reasons.

http://www.coeliac.ie

Last Updated: 1 May 2015

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Gluten Intolerance Group

The mission of the Gluten Intolerance Group of North America® is to support persons with gluten intolerances, celiac disease, dermatitis herpetiformis, and other gluten sensitivities, through consumer and industry services and programs that positively promote healthy lives.

http://www.gluten.net

Last Updated: 10 Mar 2015

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Celiac Disease Foundation

Celiac Disease Foundation drives diagnosis, treatment, and a cure for celiac disease through advocacy, education, and research to improve the quality of life for all people affected by gluten-related disorders.

http://celiac.org

Last Updated: 26 May 2016

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National Foundation for Celiac Awareness

The National Foundation for Celiac Awareness advances widespread understanding of celiac disease as a serious genetic autoimmune condition and works to secure early diagnosis and effective management. We empower our community to live life to the fullest, and serve as a leading and trusted resource that inspires hope, accelerates innovation and forges pathways to a cure.

http://www.CeliacCentral.org

Last Updated: 19 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Celiac disease" returned 991 free, full-text research articles on human participants. First 3 results:

Plasma glutamine and cystine are decreased and negatively correlated with endomysial antibody in children with celiac disease.
 

Author(s): Eylem Sevinc, Nergiz Sevinc, Himmet Haluk Akar, Banu Demet Ozelcoskun, Gülten Can Sezgin, Duran Arslan, Mustafa Kendirci

Journal: Asia Pac J Clin Nutr. 2016 ;25(3):452-6.

 

Glutamine is a nonessential amino acid which improves intestinal mucosal regeneration and absorption. Glutathione is a vital molecule for antioxidant reactions and is synthesized from cystine. The first aim of the study is to measure the plasma glutamine and cystine in children with ...

Last Updated: 21 Jul 2016

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A Case of Celiac Disease, Epilepsy, and Cerebral Calcifications With Temporal Lobe Epilepsy.
 

Author(s): Aaron F Struck, Brad R Beinlich, Paul A Rutecki

Journal: WMJ. 2015 Jun;114(3):116-7; quiz 118.

 

This is a case report of a 55-year-old man with medication refractory right temporal lobe epilepsy since adolescence. He was found to have bilateral posterior cerebral calcifications on routine head computed tomography with confirmation on magnetic resonance imaging. He also had elevated ...

Last Updated: 13 Apr 2016

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Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort.
 

Author(s): Ashok Sharma, Xiang Liu, David Hadley, William Hagopian, Edwin Liu, Wei-Min Chen, Suna Onengut-Gumuscu, Ville Simell, Marian Rewers, Anette-G Ziegler, Åke Lernmark, Olli Simell, Jorma Toppari, Jeffrey P Krischer, Beena Akolkar, Stephen S Rich, Daniel Agardh, Jin-Xiong She,

Journal:

 

There are significant geographical differences in the prevalence and incidence of celiac disease that cannot be explained by HLA alone. More than 40 loci outside of the HLA region have been associated with celiac disease. We investigated the roles of these non-HLA genes in the development ...

Last Updated: 26 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Celiac disease" returned 150 free, full-text review articles on human participants. First 3 results:

Infant feeding and risk of developing celiac disease: a systematic review.
 

Author(s): Marco Silano, Carlo Agostoni, Yolanda Sanz, Stefano Guandalini

Journal:

 

To review the evidence for the association of breast feeding, breastfeeding duration or the timing of gluten introduction and the later development of celiac disease (CD).

Last Updated: 26 Jan 2016

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Nutritional profile of adult patients with celiac disease.
 

Author(s): L Abenavoli, M Delibasic, V Peta, V Turkulov, A De Lorenzo, M Medić-Stojanoska

Journal: Eur Rev Med Pharmacol Sci. 2015 Nov;19(22):4285-92.

 

Celiac disease (CD) is a chronic immune-mediated gluten dependent enteropathy induced by ingestion of gluten, characterized by intestinal malabsorption and subtotals or total atrophy of intestinal villi. The predominant consequence of CD in untreated patients, is malnutrition as a ...

Last Updated: 5 Dec 2015

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Primary Prevention of Celiac Disease: Environmental Factors with a Focus on Early Nutrition.
 

Author(s): Anna Chmielewska, Małgorzata Pieścik-Lech, Hania Szajewska, Raanan Shamir

Journal: Ann. Nutr. Metab.. 2015 ;67 Suppl 2():43-50.

 

Celiac disease (CD) is a common autoimmune disorder caused by ingestion of gluten. When diagnosed, it should be treated with a lifelong, strict gluten-free diet. Early infant feeding practices have been suggested as a means of preventing CD. In the last few decades, observational ...

Last Updated: 27 Nov 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

MAgnetic Resonance Imaging in COeliac Disease
 

Status: Recruiting

Condition Summary: Celiac Disease; Coeliac Disease; Celiac Sprue; Gluten Enteropathy

 

Last Updated: 18 May 2016

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Celiac Disease Genomic Environmental Microbiome and Metabolomic Study
 

Status: Recruiting

Condition Summary: Celiac Disease

 

Last Updated: 12 Sep 2016

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Celiac Disease Database
 

Status: Recruiting

Condition Summary: Celiac Disease

 

Last Updated: 29 Aug 2016

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