Celiac disease

Common Name(s)

Celiac disease, Celiac sprue

Celiac disease is an autoimmune response to gluten that causes damage to the lining of the gastrointestinal tract (stomach and intestines). Gluten is a protein found in wheat, rye and barley. When an individual with celiac disease eats gluten-containing foods, their immune system overreacts and causes swelling, inflammation and damage of the small intestines. This damage leads to poor absorption of nutrients from food, weight loss, bloating, and diarrhea. Other symptoms include iron deficiency that results in a low number of red blood cells (anemia), vitamin deficiencies, low bone mineral density (osteoporosis), itchy skin rashes, defects in the enamel of the teeth, chronic fatigue, joint pain, poor growth, delayed puberty, infertility, or repeated miscarriages. Neurological problems have also been associated with celiac disease and include migraine headaches, depression, attention deficit hyperactivity disorder (ADHD), and recurrent seizures (epilepsy). The exact cause of celiac disease is unknown. However, certain variants within the HLA-DQA1 and HLA-DQB1 genes, which play a role in the immune system, can increase a person’s risk for celiac disease. Infections, surgery, childbirth, and severe emotional stress can all trigger this condition.

In order to diagnose celiac disease, a doctor may need to conduct a biopsy (removal of tissue) of the small intestine. A detailed medical history, a physical examination, and blood tests may also be needed to diagnose this condition. Treatment involves the removal of gluten-containing foods from the diet. Your doctor may also recommend specific vitamin and mineral supplements to ensure you are receiving proper nutrients. Medication is also available to treat damage that may have occurred in the small intestines. Talk with your doctor to decide which treatment option is best for you. Support groups are also good resources for additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Celiac disease" for support, advocacy or research.

Coeliac Society of Ireland

The mission of the Coeliac Society of Ireland is to improve the quality of life for Coeliacs and others who benefit from a gluten-free diet for medical reasons.

Last Updated: 1 May 2015

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Gluten Intolerance Group

The mission of the Gluten Intolerance Group of North America® is to support persons with gluten intolerances, celiac disease, dermatitis herpetiformis, and other gluten sensitivities, through consumer and industry services and programs that positively promote healthy lives.

Last Updated: 10 Mar 2015

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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Celiac Disease Foundation

Celiac Disease Foundation drives diagnosis, treatment, and a cure for celiac disease through advocacy, education, and research to improve the quality of life for all people affected by gluten-related disorders.

Last Updated: 26 May 2016

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National Foundation for Celiac Awareness

The National Foundation for Celiac Awareness advances widespread understanding of celiac disease as a serious genetic autoimmune condition and works to secure early diagnosis and effective management. We empower our community to live life to the fullest, and serve as a leading and trusted resource that inspires hope, accelerates innovation and forges pathways to a cure.

Last Updated: 19 May 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Celiac disease" for support, advocacy or research.

Coeliac Society of Ireland

The mission of the Coeliac Society of Ireland is to improve the quality of life for Coeliacs and others who benefit from a gluten-free diet for medical reasons.

http://www.coeliac.ie

Last Updated: 1 May 2015

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Gluten Intolerance Group

The mission of the Gluten Intolerance Group of North America® is to support persons with gluten intolerances, celiac disease, dermatitis herpetiformis, and other gluten sensitivities, through consumer and industry services and programs that positively promote healthy lives.

http://www.gluten.net

Last Updated: 10 Mar 2015

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Celiac Disease Foundation

Celiac Disease Foundation drives diagnosis, treatment, and a cure for celiac disease through advocacy, education, and research to improve the quality of life for all people affected by gluten-related disorders.

http://celiac.org

Last Updated: 26 May 2016

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National Foundation for Celiac Awareness

The National Foundation for Celiac Awareness advances widespread understanding of celiac disease as a serious genetic autoimmune condition and works to secure early diagnosis and effective management. We empower our community to live life to the fullest, and serve as a leading and trusted resource that inspires hope, accelerates innovation and forges pathways to a cure.

http://www.CeliacCentral.org

Last Updated: 19 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Celiac disease" returned 1039 free, full-text research articles on human participants. First 3 results:

Clinical and biological correlations in celiac disease in children: the prospective single experience of a romanian tertiary center: A case-control study (Strobe-Compliant study).
 

Author(s): Cristina Oana Marginean, Lorena Elena Meliţ, Roxana-Cristina Mareş, Maria Oana Mărginean, Septimiu Voidăzan, Minodora Dobreanu

Journal: Medicine (Baltimore). 2017 May;96(20):e6936.

 

Celiac disease-a chronic inflammatory disease of the intestine-is triggered by gluten or associated protein consumption.The aim of our study was to assess the sensitivity, specificity of the combined anti-transglutaminase 2 (TG2)/deamidated gliadin peptide antibodies (DGP), and antiendomisium ...

Last Updated: 17 May 2017

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Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study.
 

Author(s): Benjamin Lebwohl, Yin Cao, Geng Zong, Frank B Hu, Peter H R Green, Alfred I Neugut, Eric B Rimm, Laura Sampson, Lauren W Dougherty, Edward Giovannucci, Walter C Willett, Qi Sun, Andrew T Chan

Journal:

 

Objective To examine the association of long term intake of gluten with the development of incident coronary heart disease.Design Prospective cohort study.Setting and participants 64 714 women in the Nurses' Health Study and 45 303 men in the Health Professionals Follow-up ...

Last Updated: 3 May 2017

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Identification of Autophagy-Related Genes and Their Regulatory miRNAs Associated with Celiac Disease in Children.
 

Author(s): Sergio Comincini, Federico Manai, Cristina Meazza, Sara Pagani, Carolina Martinelli, Noemi Pasqua, Gloria Pelizzo, Marco Biggiogera, Mauro Bozzola

Journal:

 

Celiac disease (CD) is a severe genetic autoimmune disorder, affecting about one in 100 people, where the ingestion of gluten leads to damage in the small intestine. Diagnosing CD is quite complex and requires blood tests and intestinal biopsy examinations. Controversy exists regarding ...

Last Updated: 17 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Celiac disease" returned 162 free, full-text review articles on human participants. First 3 results:

Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence.
 

Author(s): Lyudmila V Savvateeva, Svetlana I Erdes, Anton S Antishin, Andrey A Zamyatnin

Journal: J Immunol Res. 2017 ;2017():2314813.

 

Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of dietary gluten from some cereals mainly in individuals carrying the HLA-DQ2 and/or HLA-DQ8 haplotypes. As an autoimmune disease, CD is manifested in the small intestine in the form of a progressive and ...

Last Updated: 20 Mar 2017

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Increased Incidence of Thyroid Disease in Patients with Celiac Disease: A Systematic Review and Meta-Analysis.
 

Author(s): Xin Sun, Li Lu, Rong Yang, Yanbin Li, Ling Shan, Yang Wang

Journal:

 

The prevalence of thyroid disease is likely increased among individuals with celiac disease (CD). In addition, exposure to gluten-free treatment may be associated with a risk of thyroid disease, but this association remains controversial. A systematic review was performed to evaluate ...

Last Updated: 28 Dec 2016

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Endocrine manifestations in celiac disease.
 

Author(s): Hugh James Freeman

Journal: World J. Gastroenterol.. 2016 Oct;22(38):8472-8479.

 

Celiac disease (CD) is an autoimmune small intestinal mucosal disorder that often presents with diarrhea, malabsorption and weight loss. Often, one or more associated endocrine disorders may be associated with CD. For this review, methods involved an extensive review of published ...

Last Updated: 27 Oct 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Celiac Disease Database
 

Status: Recruiting

Condition Summary: Celiac Disease

 

Last Updated: 29 Aug 2016

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Evidence-based Screening Strategies for Celiac Disease
 

Status: Not yet recruiting

Condition Summary: Celiac Disease

 

Last Updated: 26 Apr 2017

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Choosing a Preferred Serology Kit for Screening and Diagnosis of Celiac Disease
 

Status: Not yet recruiting

Condition Summary: Celiac Disease

 

Last Updated: 15 Jun 2016

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