Celiac disease

Common Name(s)

Celiac disease, Celiac sprue

Celiac disease is an autoimmune response to gluten that causes damage to the lining of the gastrointestinal tract (stomach and intestines). Gluten is a protein found in wheat, rye and barley. When an individual with celiac disease eats gluten-containing foods, their immune system overreacts and causes swelling, inflammation and damage of the small intestines. This damage leads to poor absorption of nutrients from food, weight loss, bloating, and diarrhea. Other symptoms include iron deficiency that results in a low number of red blood cells (anemia), vitamin deficiencies, low bone mineral density (osteoporosis), itchy skin rashes, defects in the enamel of the teeth, chronic fatigue, joint pain, poor growth, delayed puberty, infertility, or repeated miscarriages. Neurological problems have also been associated with celiac disease and include migraine headaches, depression, attention deficit hyperactivity disorder (ADHD), and recurrent seizures (epilepsy). The exact cause of celiac disease is unknown. However, certain variants within the HLA-DQA1 and HLA-DQB1 genes, which play a role in the immune system, can increase a person’s risk for celiac disease. Infections, surgery, childbirth, and severe emotional stress can all trigger this condition.

In order to diagnose celiac disease, a doctor may need to conduct a biopsy (removal of tissue) of the small intestine. A detailed medical history, a physical examination, and blood tests may also be needed to diagnose this condition. Treatment involves the removal of gluten-containing foods from the diet. Your doctor may also recommend specific vitamin and mineral supplements to ensure you are receiving proper nutrients. Medication is also available to treat damage that may have occurred in the small intestines. Talk with your doctor to decide which treatment option is best for you. Support groups are also good resources for additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Celiac disease" for support, advocacy or research.

Coeliac Society of Ireland

The mission of the Coeliac Society of Ireland is to improve the quality of life for Coeliacs and others who benefit from a gluten-free diet for medical reasons.

Last Updated: 1 May 2015

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Gluten Intolerance Group

The mission of the Gluten Intolerance Group of North America® is to support persons with gluten intolerances, celiac disease, dermatitis herpetiformis, and other gluten sensitivities, through consumer and industry services and programs that positively promote healthy lives.

Last Updated: 10 Mar 2015

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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Celiac Disease Foundation

Celiac Disease Foundation drives diagnosis and treatment of celiac disease through advocacy, education, and advancing research to improve the quality of life for all people affected by gluten-related disorders.

Last Updated: 20 Apr 2015

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National Foundation for Celiac Awareness

The National Foundation for Celiac Awareness advances widespread understanding of celiac disease as a serious genetic autoimmune condition and works to secure early diagnosis and effective management. We empower our community to live life to the fullest, and serve as a leading and trusted resource that inspires hope, accelerates innovation and forges pathways to a cure.

Last Updated: 19 May 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Celiac disease" for support, advocacy or research.

Coeliac Society of Ireland

The mission of the Coeliac Society of Ireland is to improve the quality of life for Coeliacs and others who benefit from a gluten-free diet for medical reasons.

http://www.coeliac.ie

Last Updated: 1 May 2015

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Gluten Intolerance Group

The mission of the Gluten Intolerance Group of North America® is to support persons with gluten intolerances, celiac disease, dermatitis herpetiformis, and other gluten sensitivities, through consumer and industry services and programs that positively promote healthy lives.

http://www.gluten.net

Last Updated: 10 Mar 2015

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Celiac Disease Foundation

Celiac Disease Foundation drives diagnosis and treatment of celiac disease through advocacy, education, and advancing research to improve the quality of life for all people affected by gluten-related disorders.

http://celiac.org

Last Updated: 20 Apr 2015

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National Foundation for Celiac Awareness

The National Foundation for Celiac Awareness advances widespread understanding of celiac disease as a serious genetic autoimmune condition and works to secure early diagnosis and effective management. We empower our community to live life to the fullest, and serve as a leading and trusted resource that inspires hope, accelerates innovation and forges pathways to a cure.

http://www.CeliacCentral.org

Last Updated: 19 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Celiac disease" returned 900 free, full-text research articles on human participants. First 3 results:

Recurrent Eosinophilic Pneumonia in a Patient with Isolated Immunoglobulin M Deficiency and Celiac Disease.
 

Author(s): Shmuel Chen, Oded Shamriz, Ori Toker, Zvi G Fridlender, Yuval Tal

Journal: Isr. Med. Assoc. J.. 2015 Aug;17(8):526-7.

 

Last Updated: 23 Sep 2015

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Bilateral Femoral Neck Fatigue Fracture due to Osteomalacia Secondary to Celiac Disease: Report of Three Cases.
 

Author(s): Ozgur Selek, Kaya Memisoglu, Alev Selek

Journal: Arch Iran Med. 2015 Aug;18(8):542-4.

 

Bilateral non traumatic femoral neck fatigue fracture is a rare condition usually occurring secondary to medical conditions such as pregnancy, pelvic irradiation, corticosteroid exposure, chronic renal failure and osteomalacia. In this report, we present three young female patients ...

Last Updated: 12 Aug 2015

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Structural Basis for Antigen Recognition by Transglutaminase 2-specific Autoantibodies in Celiac Disease.
 

Author(s): Xi Chen, Kathrin Hnida, Melissa Ann Graewert, Jan Terje Andersen, Rasmus Iversen, Anne Tuukkanen, Dmitri Svergun, Ludvig M Sollid

Journal: J. Biol. Chem.. 2015 Aug;290(35):21365-75.

 

Antibodies to the autoantigen transglutaminase 2 (TG2) are a hallmark of celiac disease. We have studied the interaction between TG2 and an anti-TG2 antibody (679-14-E06) derived from a single gut IgA plasma cell of a celiac disease patient. The antibody recognizes one of four identified ...

Last Updated: 31 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Celiac disease" returned 131 free, full-text review articles on human participants. First 3 results:

Celiac disease and non-celiac gluten sensitivity.
 

Author(s): Benjamin Lebwohl, Jonas F Ludvigsson, Peter H R Green

Journal:

 

Celiac disease is a multisystem immune based disorder that is triggered by the ingestion of gluten in genetically susceptible individuals. The prevalence of celiac disease has risen in recent decades and is currently about 1% in most Western populations. The reason for this rise is ...

Last Updated: 6 Oct 2015

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Liver involvement in pediatric celiac disease.
 

Author(s): Caterina Anania, Ester De Luca, Giovanna De Castro, Claudio Chiesa, Lucia Pacifico

Journal: World J. Gastroenterol.. 2015 May;21(19):5813-22.

 

Celiac disease (CD) is an intestinal inflammatory disease that manifests in genetically susceptible individuals when exposed to dietary gluten. It is a common chronic disorder, with a prevalence of 1% in Europe and North America. Although the disease primarily affects the gut, the ...

Last Updated: 28 May 2015

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Bones of contention: bone mineral density recovery in celiac disease--a systematic review.
 

Author(s): Patricia Grace-Farfaglia

Journal:

 

Metabolic bone disease is a frequent co-morbidity in newly diagnosed adults with celiac disease (CD), an autoimmune disorder triggered by the ingestion of dietary gluten. This systematic review of studies looked at the efficacy of the gluten-free diet, physical activity, nutrient ...

Last Updated: 12 May 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

MAgnetic Resonance Imaging in COeliac Disease
 

Status: Recruiting

Condition Summary: Celiac Disease; Coeliac Disease; Celiac Sprue; Gluten Enteropathy

 

Last Updated: 15 Sep 2015

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Antibody Treatment for Advanced Celiac Disease
 

Status: Recruiting

Condition Summary: Celiac Disease; Celiac Sprue; Gluten Enteropathy; Gluten-Sensitive Enteropathy

 

Last Updated: 16 Apr 2015

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Celiac Disease Database
 

Status: Recruiting

Condition Summary: Celiac Disease

 

Last Updated: 2 Dec 2013

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