Celiac disease

Common Name(s)

Celiac disease, Celiac sprue

Celiac disease is an autoimmune response to gluten that causes damage to the lining of the gastrointestinal tract (stomach and intestines). Gluten is a protein found in wheat, rye and barley. When an individual with celiac disease eats gluten-containing foods, their immune system overreacts and causes swelling, inflammation and damage of the small intestines. This damage leads to poor absorption of nutrients from food, weight loss, bloating, and diarrhea. Other symptoms include iron deficiency that results in a low number of red blood cells (anemia), vitamin deficiencies, low bone mineral density (osteoporosis), itchy skin rashes, defects in the enamel of the teeth, chronic fatigue, joint pain, poor growth, delayed puberty, infertility, or repeated miscarriages. Neurological problems have also been associated with celiac disease and include migraine headaches, depression, attention deficit hyperactivity disorder (ADHD), and recurrent seizures (epilepsy). The exact cause of celiac disease is unknown. However, certain variants within the HLA-DQA1 and HLA-DQB1 genes, which play a role in the immune system, can increase a person’s risk for celiac disease. Infections, surgery, childbirth, and severe emotional stress can all trigger this condition.

In order to diagnose celiac disease, a doctor may need to conduct a biopsy (removal of tissue) of the small intestine. A detailed medical history, a physical examination, and blood tests may also be needed to diagnose this condition. Treatment involves the removal of gluten-containing foods from the diet. Your doctor may also recommend specific vitamin and mineral supplements to ensure you are receiving proper nutrients. Medication is also available to treat damage that may have occurred in the small intestines. Talk with your doctor to decide which treatment option is best for you. Support groups are also good resources for additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Celiac disease" for support, advocacy or research.

Coeliac Society of Ireland

The mission of the Coeliac Society of Ireland is to improve the quality of life for Coeliacs and others who benefit from a gluten-free diet for medical reasons.

Last Updated: 1 May 2015

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Gluten Intolerance Group

The mission of the Gluten Intolerance Group of North America® is to support persons with gluten intolerances, celiac disease, dermatitis herpetiformis, and other gluten sensitivities, through consumer and industry services and programs that positively promote healthy lives.

Last Updated: 10 Mar 2015

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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Celiac Disease Foundation

Celiac Disease Foundation drives diagnosis and treatment of celiac disease through advocacy, education, and advancing research to improve the quality of life for all people affected by gluten-related disorders.

Last Updated: 20 Apr 2015

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National Foundation for Celiac Awareness

The National Foundation for Celiac Awareness advances widespread understanding of celiac disease as a serious genetic autoimmune condition and works to secure early diagnosis and effective management. We empower our community to live life to the fullest, and serve as a leading and trusted resource that inspires hope, accelerates innovation and forges pathways to a cure.

Last Updated: 19 May 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Celiac disease" for support, advocacy or research.

Coeliac Society of Ireland

The mission of the Coeliac Society of Ireland is to improve the quality of life for Coeliacs and others who benefit from a gluten-free diet for medical reasons.

http://www.coeliac.ie

Last Updated: 1 May 2015

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Gluten Intolerance Group

The mission of the Gluten Intolerance Group of North America® is to support persons with gluten intolerances, celiac disease, dermatitis herpetiformis, and other gluten sensitivities, through consumer and industry services and programs that positively promote healthy lives.

http://www.gluten.net

Last Updated: 10 Mar 2015

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Celiac Disease Foundation

Celiac Disease Foundation drives diagnosis and treatment of celiac disease through advocacy, education, and advancing research to improve the quality of life for all people affected by gluten-related disorders.

http://celiac.org

Last Updated: 20 Apr 2015

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National Foundation for Celiac Awareness

The National Foundation for Celiac Awareness advances widespread understanding of celiac disease as a serious genetic autoimmune condition and works to secure early diagnosis and effective management. We empower our community to live life to the fullest, and serve as a leading and trusted resource that inspires hope, accelerates innovation and forges pathways to a cure.

http://www.CeliacCentral.org

Last Updated: 19 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Celiac disease" returned 838 free, full-text research articles on human participants. First 3 results:

Correlation of endoscopic and histological features in adults with suspected celiac disease in a referral center of Minas Gerais, Brazil.
 

Author(s): Rodrigo Macedo Rosa, Maria de Lourdes Abreu Ferrari, Moisés Salgado Pedrosa, Gustavo Meirelles Ribeiro, Geraldo Brasileiro-Filho, Aloísio Sales da Cunha

Journal: Arq Gastroenterol. ;51(4):290-6.

 

Clinical presentation of celiac disease is extremely variable and the diagnosis relies on serologic tests, mucosal intestinal biopsy and clinic and serologic response to a gluten-free diet.

Last Updated: 16 Jan 2015

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Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires.
 

Author(s): Elin Bergseng, Siri Dørum, Magnus Ø Arntzen, Morten Nielsen, Ståle Nygård, Søren Buus, Gustavo A de Souza, Ludvig M Sollid

Journal: Immunogenetics. 2015 Feb;67(2):73-84.

 

Celiac disease is caused by intolerance to cereal gluten proteins, and HLA-DQ molecules are involved in the disease pathogenesis by presentation of gluten peptides to CD4(+) T cells. The α- or β-chain sharing HLA molecules DQ2.5, DQ2.2, and DQ7.5 display different risks for the ...

Last Updated: 17 Jan 2015

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Celiac disease with cerebral and peripheral nerve involvement mimicking multiple sclerosis.
 

Author(s): J Finsterer, F Leutmezer

Journal: J Med Life. 2014 Sep;7(3):440-4.

 

Due to the similarity in the clinical presentation, morphology, and course, celiac disease (CD) may be mixed up with other immunological disorders, such as multiple sclerosis (MS).

Last Updated: 21 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Celiac disease" returned 121 free, full-text review articles on human participants. First 3 results:

Long term follow up of celiac disease-is atherosclerosis a problem?
 

Author(s): Anna Rybak, Bożena Cukrowska, Jerzy Socha, Piotr Socha

Journal:

 

Celiac disease (CD) is a lifelong condition and it often involves impaired nutrition, wide spectrum of symptoms and it requires constant dietetic treatment. The impact of the gluten-free diet on patients' nutritional status and on the other biochemical parameters is being widely investigated. ...

Last Updated: 23 Jul 2014

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Risk of infertility in patients with celiac disease: a meta-analysis of observational studies.
 

Author(s): Juan Sebastian Lasa, Ignacio Zubiaurre, Luis Oscar Soifer

Journal: Arq Gastroenterol. ;51(2):144-50.

 

Celiac disease is an autoimmune disorder of the small intestine associated with several extra-intestinal features, such as reproductive disorders. The relationship between celiac disease and infertility has been previously assessed, with conflicting results.

Last Updated: 9 Jul 2014

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Intestinal microbiota and probiotics in celiac disease.
 

Author(s): Luís Fernando de Sousa Moraes, Lukasz Marcin Grzeskowiak, Tatiana Fiche de Sales Teixeira, Maria do Carmo Gouveia Peluzio

Journal: Clin. Microbiol. Rev.. 2014 Jul;27(3):482-9.

 

Celiac disease (CD) is a common chronic autoimmune enteropathy caused by gluten intake. To date, the only therapy for CD is the complete exclusion of dietary sources of grains and any food containing gluten. It has been hypothesized that the intestinal microbiota is somehow involved ...

Last Updated: 1 Jul 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Antibody Treatment for Advanced Celiac Disease
 

Status: Recruiting

Condition Summary: Celiac Disease; Celiac Sprue; Gluten Enteropathy; Gluten-Sensitive Enteropathy

 

Last Updated: 16 Apr 2015

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Screen-detected Coeliac Disease, a Population Based Study
 

Status: Recruiting

Condition Summary: Celiac Disease

 

Last Updated: 11 Dec 2014

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Celiac Disease Database
 

Status: Recruiting

Condition Summary: Celiac Disease

 

Last Updated: 2 Dec 2013

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