Carney Complex

Common Name(s)

Carney Complex

Carney complex is a hereditary cancer syndrome characterized by spotty skin pigmentation, cardiac (heart) myxomas (tumors composed of mucous connective tissue), skin myxomas, and endocrine gland tumors. Some families with this condition have been found to have mutations in the PRKAR1A gene. Carney syndrome is believed to be inherited in an autosomal dominant manner, which means that an affected parent has a 50% chance of passing on the affected gene to each of his/her children.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Carney Complex" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Carney Complex" returned 47 free, full-text research articles on human participants. First 3 results:

PRKACB and Carney complex.
 

Author(s): Antonella Forlino, Annalisa Vetro, Livia Garavelli, Roberto Ciccone, Edra London, Constantine A Stratakis, Orsetta Zuffardi

Journal: N. Engl. J. Med.. 2014 Mar;370(11):1065-7.

 

Last Updated: 13 Mar 2014

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PKA RI╬▒ homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease.
 

Author(s): Jessica G H Bruystens, Jian Wu, Audrey Fortezzo, Alexandr P Kornev, Donald K Blumenthal, Susan S Taylor

Journal: Structure. 2014 Jan;22(1):59-69.

 

The regulatory (R) subunit is the cAMP receptor of protein kinase A. Following cAMP binding, the inactive PKA holoenzyme complex separates into two active catalytic (C) subunits and a cAMP-bound R dimer. Thus far, only monomeric R structures have been solved, which fell short in explaining ...

Last Updated: 13 Jan 2014

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An unusual presentation of Carney complex with diffuse primary pigmented nodular adrenocortical disease on one adrenal gland and a nonpigmented adrenocortical adenoma and focal primary pigmented nodular adrenocortical disease on the other.
 

Author(s): Shih-Chen Tung, Daw-Yang Hwang, Joseph W Yang, Wei-Jen Chen, Chien-Te Lee

Journal: Endocr. J.. 2012 Sep;59(9):823-30.

 

A 24-year-old female patient with cushingoid appearance was admitted in May 2000. The endocrine studies showed ACTH-independent Cushing's syndrome. A 2-day high-dose dexamethasone suppression test (HDDST) revealed paradoxical increase of 24 h urinary free cortisol (UFC). Abdominal ...

Last Updated: 5 Oct 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Carney Complex" returned 9 free, full-text review articles on human participants. First 3 results:

Genetic predisposition to peripheral nerve neoplasia: diagnostic criteria and pathogenesis of neurofibromatoses, Carney complex, and related syndromes.
 

Author(s): Fausto J Rodriguez, Constantine A Stratakis, D Gareth Evans

Journal: Acta Neuropathol.. 2012 Mar;123(3):349-67.

 

Neoplasms of the peripheral nerve sheath represent essential clinical manifestations of the syndromes known as the neurofibromatoses. Although involvement of multiple organ systems, including skin, central nervous system, and skeleton, may also be conspicuous, peripheral nerve neoplasia ...

Last Updated: 21 Feb 2012

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Carney complex and lentiginosis.
 

Author(s): Anelia Horvath, Constantine A Stratakis

Journal: Pigment Cell Melanoma Res. 2009 Oct;22(5):580-7.

 

Initially described as the 'complex of myxomas, spotty skin pigmentation and endocrine overactivity,' Carney complex (CNC) is known as an autosomal dominant multiple neoplasia syndrome involving skin and cardiac myxomas, pigmented skin lesions and endocrine tumors. Pigmented cutaneous ...

Last Updated: 28 Aug 2009

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The Carney complex gene PRKAR1A plays an essential role in cardiac development and myxomagenesis.
 

Author(s): Zhirong Yin, Lawrence S Kirschner

Journal: Trends Cardiovasc. Med.. 2009 Feb;19(2):44-9.

 

Cardiac myxomas are the most common primary tumors of the heart, although little is known about their etiology. Mutations of the protein kinase A regulatory subunit gene PRKAR1A cause inherited myxomas in the setting of the Carney complex tumor syndrome, providing a possible window ...

Last Updated: 6 Jul 2009

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
 

Status: Recruiting

Condition Summary: Cushing's Syndrome; Hereditary Neoplastic Syndrome; Lentigo; Neoplasm; Testicular Neoplasm

 

Last Updated: 3 Apr 2014

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