Carney Complex

Common Name(s)

Carney Complex

Carney complex is a hereditary cancer syndrome characterized by spotty skin pigmentation, cardiac (heart) myxomas (tumors composed of mucous connective tissue), skin myxomas, and endocrine gland tumors. Some families with this condition have been found to have mutations in the PRKAR1A gene. Carney syndrome is believed to be inherited in an autosomal dominant manner, which means that an affected parent has a 50% chance of passing on the affected gene to each of his/her children.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Carney Complex" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Carney Complex" returned 61 free, full-text research articles on human participants. First 3 results:

Psammomatous melanotic schwannoma as a component of Carney complex.
 

Author(s): Salapathi Shanmugam, Mitra Ghosh, Sadiya Niamathullah, Siddhartha Ghosh

Journal: Indian J Pathol Microbiol. ;58(3):368-70.

 

Melanotic schwannoma is a rare form of pigmented neural tumor commonly arising from the posterior spinal nerves and ganglia. Two variants have been described, psammomatous and nonpsammomatous. 50% of psammomatous tumors are associated with Carney complex. The biologic behavior of ...

Last Updated: 15 Aug 2015

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A case of familial Carney complex.
 

Author(s): Yan Li Zhang, Xiao Cong Wang, Wei Yu, Li Ping Pei, Yan Ma, Shu Jiang, Yun Peng Sun

Journal: Arch Iran Med. 2015 May;18(5):324-8.

 

Carney complex is a syndrome characterized by skin pigmentation abnormalities, myxomas, endocrine tumors/overactivity, and schwannomas. It is caused by a mutation in the PRKAR1A gene that encodes the enzyme protein kinase A regulatory subunit type 1 alpha. A 23-year old male was diagnosed ...

Last Updated: 11 May 2015

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Case studies of two related Chinese patients with Carney complex presenting with extensive cardiac myxomas and PRKAR1A gene mutation of c.491_492delTG.
 

Author(s): Hongwei Guo, Jianping Xu, Hui Xiong, Shengshou Hu

Journal:

 

Carney complex is an autosomal dominant disease that is clinically characterized by cardiac myxomas, spotty skin pigmentation, and endocrine overactivity. Carney complex is most commonly caused by mutations in the PRKAR1A gene on chromosome 17q22-24. Currently, there are at least ...

Last Updated: 19 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Carney Complex" returned 15 free, full-text review articles on human participants. First 3 results:

Carney complex: an update.
 

Author(s): Ricardo Correa, Paraskevi Salpea, Constantine A Stratakis

Journal: Eur. J. Endocrinol.. 2015 Oct;173(4):M85-97.

 

Carney complex (CNC) is a rare autosomal dominant syndrome, characterized by pigmented lesions of the skin and mucosa, cardiac, cutaneous and other myxomas and multiple endocrine tumors. The disease is caused by inactivating mutations or large deletions of the PRKAR1A gene located ...

Last Updated: 28 Aug 2015

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Carney complex and McCune Albright syndrome: an overview of clinical manifestations and human molecular genetics.
 

Author(s): Paraskevi Salpea, Constantine A Stratakis

Journal: Mol. Cell. Endocrinol.. 2014 Apr;386(1-2):85-91.

 

Endocrine neoplasia syndromes feature a wide spectrum of benign and malignant tumors of endocrine and non-endocrine organs associated with other clinical manifestations. This study outlines the main clinical features, genetic basis, and molecular mechanisms behind two multiple endocrine ...

Last Updated: 3 Mar 2014

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Carney complex with right ventricular myxoma following second excision of left atrial myxoma.
 

Author(s): Yamato Tamura, Toshio Seki

Journal: Ann Thorac Cardiovasc Surg. 2014 ;20 Suppl():882-4.

 

We report a case of Carney complex with massive right ventricular myxoma after two-time excision of a left atrial myxoma. The patient was a 45-year-old woman with pyrexia. She temporarily lost consciousness during examination, and echocardiography and computed tomography (CT) showed ...

Last Updated: 6 Mar 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
 

Status: Recruiting

Condition Summary: Cushing's Syndrome; Hereditary Neoplastic Syndrome; Lentigo; Neoplasm; Testicular Neoplasm

 

Last Updated: 11 May 2016

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