Burkitt's Lymphoma

Common Name(s)

Burkitt's Lymphoma

Burkitt lymphoma is a rare, aggressive B-cell lymphoma that accounts for 30 to 50% of lymphomas in children but only 1 to 2% of lymphomas in adults ({10:Harris and Horning, 2006}). It results from chromosomal translocations that involve the MYC gene ({190080}) and either the lambda or the kappa light chain immunoglobulin genes ({147220}, {147200}). Burkitt lymphoma is causally related to the Epstein-Barr virus (EBV), although the pathogenetic mechanisms are not clear.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Burkitt's Lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Burkitt's Lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Burkitt's Lymphoma" returned 367 free, full-text research articles on human participants. First 3 results:

Exosomes derived from Burkitt's lymphoma cell lines induce proliferation, differentiation, and class-switch recombination in B cells.
 

Author(s): Cindy Gutzeit, Noemi Nagy, Maurizio Gentile, Katarina Lyberg, Janine Gumz, Helen Vallhov, Irene Puga, Eva Klein, Susanne Gabrielsson, Andrea Cerutti, Annika Scheynius

Journal: J. Immunol.. 2014 Jun;192(12):5852-62.

 

Exosomes, nano-sized membrane vesicles, are released by various cells and are found in many human body fluids. They are active players in intercellular communication and have immune-suppressive, immune-regulatory, and immune-stimulatory functions. EBV is a ubiquitous human herpesvirus ...

Last Updated: 9 Jun 2014

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Low-intensity therapy in adults with Burkitt's lymphoma.
 

Author(s): Kieron Dunleavy, Stefania Pittaluga, Margaret Shovlin, Seth M Steinberg, Diane Cole, Cliona Grant, Brigitte Widemann, Louis M Staudt, Elaine S Jaffe, Richard F Little, Wyndham H Wilson

Journal: N. Engl. J. Med.. 2013 Nov;369(20):1915-25.

 

Burkitt's lymphoma is an aggressive B-cell lymphoma that occurs in children and adults and is largely curable with the use of intensive and toxic chemotherapy. Current treatments are less effective and have more severe side effects in adults and patients with immunodeficiency than in children.

Last Updated: 14 Nov 2013

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Downregulation of the polyamine regulator spermidine/spermine N(1)-acetyltransferase by Epstein-Barr virus in a Burkitt's lymphoma cell line.
 

Author(s): Mingxia Shi, Yan-Jun Gan, Timothy O Davis, Rona S Scott

Journal: Virus Res.. 2013 Oct;177(1):11-21.

 

Transition of Akata Burkitt's lymphoma (BL) from a malignant to nonmalignant phenotype upon loss of Epstein-Barr virus (EBV) is evidence for a viral contribution to tumorigenesis despite the tight restriction of EBV gene expression in BL. Examination of global cellular gene expression ...

Last Updated: 9 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Burkitt's Lymphoma" returned 13 free, full-text review articles on human participants. First 3 results:

Primary hepatic circumscribed Burkitt's lymphoma that developed after acute hepatitis B: report of a case with a review of the literature.
 

Author(s): Yasunobu Sekiguchi, Hitomi Yoshikawa, Asami Shimada, Hidenori Imai, Mutsumi Wakabayashi, Keiji Sugimoto, Noriko Nakamura, Tomohiro Sawada, Kengo Takeuchi, Yasunori Ohta, Norio Komatsu, Masaaki Noguchi

Journal: J Clin Exp Hematop. 2013 ;53(2):167-73.

 

A Japanese man aged 30 years old contracted acute hepatitis B in October 2011, and was cured following conservative treatment. Mild hepatosplenomegaly was the only positive finding on computed tomography (CT) and ultrasonography at that time. In May 2012, slight impairment of the ...

Last Updated: 2 Sep 2013

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Atypical Burkitt's lymphoma transforming from follicular lymphoma.
 

Author(s): Yu Y Hwang, Florence Loong, Lap P Chung, Chor S Chim

Journal:

 

Amongst follicular lymphoma that transforms into a high-grade lymphoma, majority are diffuse large B cell lymphoma. Here we reported a rare atypical Burkitt's lymphoma transformation from an asymptomatic follicular lymphoma. Lymph node biopsy showed a composite lymphoma with infiltration ...

Last Updated: 27 Jul 2011

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The gray zone between Burkitt's lymphoma and diffuse large B-cell lymphoma from a genetics perspective.
 

Author(s): Itziar Salaverria, Reiner Siebert

Journal: J. Clin. Oncol.. 2011 May;29(14):1835-43.

 

It has long been recognized that the border between classical Burkitt's lymphoma (BL) and classical diffuse large B-cell lymphoma (DLBCL) is hard to determine. Instead, both classical lymphoma entities seem to be the extreme ends of a spectrum of diseases that contains a group of ...

Last Updated: 9 May 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-Grade Lymphoma in Adults
 

Status: Recruiting

Condition Summary: Burkitt's Lymphoma; Burkitt's Leukemia; Mediastinal Neoplasms; Lymphoblastic Lymphoma; Large Cell Anaplastic Lymphoma

 

Last Updated: 29 May 2008

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Short Term Intensified Chemo-immunotherapy in HIV-positive Patients With Burkitt Lymphoma
 

Status: Recruiting

Condition Summary: HIV; Burkitt's Lymphoma

 

Last Updated: 24 Jan 2012

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Phase II Study of Dose-Adjusted EPOCH-Rituximab in Adults With Untreated Burkitt Lymphoma and c-MYC+ Diffuse Large B-Cell Lymphoma
 

Status: Recruiting

Condition Summary: Burkitt Lymphoma; Diffuse Large B-cell Lymphoma, c-MYC Positive; Plasmablastic Lymphoma

 

Last Updated: 27 Sep 2014

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