Brugada Syndrome

Common Name(s)

Brugada Syndrome

Brugada syndrome is a condition that causes a disruption of the heart's normal rhythm (arrhythmia). Signs and symptoms usually develop in adulthood and include ventricular arrhythmia that can cause fainting, seizures, difficulty breathing, or sudden death. These complications often occur when an affected person is resting or asleep. Brugada syndrome is inherited in an autosomal dominant manner and may be caused by a mutation in any of several genes (most commonly the SCN5A gene). In many cases, the genetic cause is not identified. There have also been reports of acquired Brugada syndrome which have been associated with adverse reactions to certain drugs or other substances. Treatment may include use of an implantable cardioverter defibrillator (ICD) in people with a history of fainting or heart attack.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brugada Syndrome" for support, advocacy or research.

SADS (Sudden Arrhythmia Death Syndromes) Foundation

Our mission is to save the lives of young people who are genetically predisposed to sudden death due to cardiac arrhythmia and to provide education and support to families and the medical community.

Last Updated: 23 Apr 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brugada Syndrome" for support, advocacy or research.

SADS (Sudden Arrhythmia Death Syndromes) Foundation

Our mission is to save the lives of young people who are genetically predisposed to sudden death due to cardiac arrhythmia and to provide education and support to families and the medical community.

http://www.StopSADS.org

Last Updated: 23 Apr 2015

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General Resources

SADS Foundation Website

Information on living with SADS, diagnosis, treatment, prevention, and advocacy/education.

Updated 29 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Brugada Syndrome" returned 376 free, full-text research articles on human participants. First 3 results:

Case report: an unusual case of Brugada syndrome combined with a ventricular septal defect: A case report.
 

Author(s): Xing Liu, Jianmei Zheng, Zhongcai Fan, Li Rao

Journal: Medicine (Baltimore). 2017 Nov;96(47):e8695.

 

Brugada syndrome (BrS) is a cardiac ion channel disease that is caused by an autosomal dominant genetic abnormality. A ventricular septal defect is a common congenital heart disease, in which genetic defects play a significant role.

Last Updated: 31 Dec 1969

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A Report of Brugada Syndrome Presenting with Cardiac Arrest Triggered by Verapamil Intoxication.
 

Author(s): Kahraman Yakut, İlkay Erdoğan, Birgül Varan, İlyas Atar

Journal: Balkan Med J. 2017 12;34(6):576-579.

 

Brugada syndrome is a disease characterized by a specific electrocardiographic pattern and an increased risk of sudden cardiac death. We present this case with the updated literature to emphasise the need to consider the diagnosis of Brugada syndrome in patients admitted to the emergency ...

Last Updated: 31 Dec 1969

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Ajmaline blocks I and I without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters.
 

Author(s): Duncan C Miller, Stephen C Harmer, Ariel Poliandri, Muriel Nobles, Elizabeth C Edwards, James S Ware, Tyson V Sharp, Tristan R McKay, Leo Dunkel, Pier D Lambiase, Andrew Tinker

Journal: Stem Cell Res. 2017 12;25():233-244.

 

The class Ia anti-arrhythmic drug ajmaline is used clinically to unmask latent type I ECG in Brugada syndrome (BrS) patients, although its mode of action is poorly characterised. Our aims were to identify ajmaline's mode of action in human induced pluripotent stem cell (hiPSC)-derived ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Brugada Syndrome" returned 54 free, full-text review articles on human participants. First 3 results:

Brugada syndrome: Diagnosis, risk stratification and management.
 

Author(s): Jean-Baptiste Gourraud, Julien Barc, Aurélie Thollet, Hervé Le Marec, Vincent Probst

Journal: Arch Cardiovasc Dis. 2017 Mar;110(3):188-195.

 

Brugada syndrome is a rare inherited arrhythmia syndrome leading to an increased risk of sudden cardiac death, despite a structurally normal heart. Diagnosis is based on a specific electrocardiogram pattern, observed either spontaneously or during a sodium channel blocker test. Among ...

Last Updated: 31 Dec 1969

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The Brugada Syndrome - From Gene to Therapy.
 

Author(s): Antonio Curcio, Giuseppe Santarpia, Ciro Indolfi

Journal: Circ. J.. 2017 Feb;81(3):290-297.

 

It is almost a quarter of century that a pioneering work of 2 researchers named Brugada brought the entire scientific community to understanding the molecular, clinical, and electrophysiological aspects of a distinctive syndrome. It affects mainly young adults with syncope and/or ...

Last Updated: 31 Dec 1969

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Risk factors for cardiac events in patients with Brugada syndrome: A PRISMA-compliant meta-analysis and systematic review.
 

Author(s): Wenqing Wu, Li Tian, Jinshan Ke, Yi Sun, Ruixia Wu, Jianfang Zhu, Qinmei Ke

Journal: Medicine (Baltimore). 2016 Jul;95(30):e4214.

 

Inconsistent results have been reported about the risk stratification of patients with Brugada syndrome. We have summarized the evidence regarding the strength of association between 6 risk factors (family history of sudden cardiac death [SCD] or syncope, inducible ventricular arrhythmias ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Brugada Syndrome: a Follow-up Study
 

Status: Recruiting

Condition Summary: Brugada Syndrome

 

Last Updated: 26 Mar 2018

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Ripple Mapping for Epicardial Mapping of Brugada Syndrome
 

Status: Recruiting

Condition Summary: Brugada Syndrome

 

Last Updated: 15 Feb 2018

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Ablation in Brugada Syndrome for the Prevention of VF
 

Status: Recruiting

Condition Summary: Brugada Syndrome

 

Last Updated: 25 Sep 2017

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