Blepharospasm

Common Name(s)

Blepharospasm, Benign Essential Blepharospasm (BEB)

Benign essential blepharospasm is a progressive neurological disorder characterized by involuntary muscle contractions and spasms of the eyelid muscles. It is a form of dystonia, a movement disorder in which muscle contractions cause sustained eyelid closure, twitching or repetitive movements. Benign essential blepharospasm occurs in both men and women, although it is especially common in middle-aged and elderly women. Most cases are treated with botulinum toxin injections. The exact cause of benign essential blepharospasm is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Blepharospasm" for support, advocacy or research.

Benign Essential Blepharospasm Research Foundation, Inc.

The Mission of the Benign Essential Blepharospasm Research Foundation, Inc. is to fund and promote medical research in the search for the cause and cure of blepharospasm, Meige, and other related disorders of the facial musculature, to provide support, education and referrals to persons with these disorders, and to disseminate information and serve as an authoritative resource to the medical community and the general public.

Last Updated: 3 Mar 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Blepharospasm" for support, advocacy or research.

Benign Essential Blepharospasm Research Foundation, Inc.

The Mission of the Benign Essential Blepharospasm Research Foundation, Inc. is to fund and promote medical research in the search for the cause and cure of blepharospasm, Meige, and other related disorders of the facial musculature, to provide support, education and referrals to persons with these disorders, and to disseminate information and serve as an authoritative resource to the medical community and the general public.

http://www.blepharospasm.org/

Last Updated: 3 Mar 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Blepharospasm" returned 89 free, full-text research articles on human participants. First 3 results:

Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy.
 

Author(s): Hanganu Alexandru, Muthuraman Muthuraman, Venkata Chaitanya Chirumamilla, Nabin Koirala, Burcu Paktas, Günther Deuschl, Kirsten E Zeuner, Sergiu Groppa

Journal:

 

Benign Essential Blepharospasm (BEB) and hemifacial spasm (HFS) are the most common hyperkinetic movement disorders of facial muscles. Although similar in clinical presentation different pathophysiological mechanisms are assumed. Botulinum Neurotoxin (BoNT) is a standard evidence-based ...

Last Updated: 19 Dec 2016

Go To URL
A novel ANO3 variant identified in a 53-year-old woman presenting with hyperkinetic dysarthria, blepharospasm, hyperkinesias, and complex motor tics.
 

Author(s): Patrick R Blackburn, Michael T Zimmermann, Jennifer M Gass, Kimberly G Harris, Margot A Cousin, Nicole J Boczek, Owen A Ross, Eric W Klee, Paul W Brazis, Jay A Van Gerpen, Paldeep S Atwal

Journal:

 

Cervical dystonias have a variable presentation and underlying etiology, but collectively represent the most common form of focal dystonia. There are a number of known genetic forms of dystonia (DYT1-27); however the heterogeneity of disease presentation does not always make it easy ...

Last Updated: 6 Dec 2016

Go To URL
Screening for Cognitive Impairments in Primary Blepharospasm.
 

Author(s): Jing Yang, Wei Song, Qianqian Wei, Ruwei Ou, Bei Cao, Wanglin Liu, Na Shao, Hui-Fang Shang

Journal:

 

Studies have reported that non-motor symptoms are an important component of primary dystonia. However, evidence supporting cognitive impairment in primary dystonia is limited and contradictory.

Last Updated: 16 Aug 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Blepharospasm" returned 7 free, full-text review articles on human participants. First 3 results:

Secondary blepharospasm associated with structural lesions of the brain.
 

Author(s): M A Khooshnoodi, S A Factor, H A Jinnah

Journal: J. Neurol. Sci.. 2013 Aug;331(1-2):98-101.

 

Blepharospasm is a form of focal dystonia that manifests as repetitive involuntary closure of the eyes. The pathogenesis of blepharospasm and the neuroanatomic substrates involved are not fully understood. Dysfunction of the basal ganglia traditionally is presumed to be the main cause ...

Last Updated: 8 Jul 2013

Go To URL
[Essential blepharospasm: literature review].
 

Author(s): André Gustavo Bombana Nicoletti, Lísia Aoki, Tatiana Rizkallah Nahas, Suzana Matayoshi

Journal: Arq Bras Oftalmol. ;73(5):469-73.

 

Essential blepharospasm is a focal distonia characterized by involuntary, spasmodic, bilateral contractions of eyelid protractors. This is a rare disease, which diagnosis is frequently late and symptoms may progress until functional blindness. In this article, we perform a review ...

Last Updated: 12 Jan 2011

Go To URL
Difficulties with differentiating botulinum toxin treatment effects in essential blepharospasm.
 

Author(s): Bettina Wabbels, Wolfgang H Jost, Peter Roggenkämper

Journal: J Neural Transm (Vienna). 2011 Jun;118(6):925-43.

 

Blepharospasm is a focal dystonia in which the extraocular muscles contract repetitively, leading to excessive blinking and forced eyelid closure. Botulinum toxin type A (BoNTA) is the primary symptomatic treatment for blepharospasm and its effects have been evaluated using numerous ...

Last Updated: 31 May 2011

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Two Different Surgical Methods of Blepharospasm
 

Status: Not yet recruiting

Condition Summary: Blepharospasm

 

Last Updated: 4 May 2016

Go to URL
Photic Blink Reflex in People With Blepharospasm and Increased Blinking
 

Status: Recruiting

Condition Summary: Blepharospasm

 

Last Updated: 19 Oct 2017

Go to URL
Safety and Efficacy of NABOTA in Treatment of Essential Blepharospasm
 

Status: Recruiting

Condition Summary: Blepharospasm

 

Last Updated: 26 Oct 2016

Go to URL