Blepharospasm

Common Name(s)

Blepharospasm, Benign Essential Blepharospasm (BEB)

Benign essential blepharospasm is a progressive neurological disorder characterized by involuntary muscle contractions and spasms of the eyelid muscles. It is a form of dystonia, a movement disorder in which muscle contractions cause sustained eyelid closure, twitching or repetitive movements. Benign essential blepharospasm occurs in both men and women, although it is especially common in middle-aged and elderly women. Most cases are treated with botulinum toxin injections. The exact cause of benign essential blepharospasm is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Blepharospasm" for support, advocacy or research.

Benign Essential Blepharospasm Research Foundation, Inc.

The Mission of the Benign Essential Blepharospasm Research Foundation, Inc. is to fund and promote medical research in the search for the cause and cure of blepharospasm, Meige, and other related disorders of the facial musculature, to provide support, education and referrals to persons with these disorders, and to disseminate information and serve as an authoritative resource to the medical community and the general public.

http://www.blepharospasm.org/

Last Updated: 22 Oct 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Blepharospasm" for support, advocacy or research.

Benign Essential Blepharospasm Research Foundation, Inc.

The Mission of the Benign Essential Blepharospasm Research Foundation, Inc. is to fund and promote medical research in the search for the cause and cure of blepharospasm, Meige, and other related disorders of the facial musculature, to provide support, education and referrals to persons with these disorders, and to disseminate information and serve as an authoritative resource to the medical community and the general public.

http://www.blepharospasm.org/

Last Updated: 22 Oct 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Blepharospasm" returned 65 free, full-text research articles on human participants. First 3 results:

Last Updated: 22 Apr 2013

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Sustained efficacy and safety of repeated incobotulinumtoxinA (Xeomin(®)) injections in blepharospasm.
 

Author(s): Daniel D Truong, Stephen M Gollomp, Joseph Jankovic, Peter A LeWitt, Michael Marx, Angelika Hanschmann, Hubert H Fernandez,

Journal: J Neural Transm. 2013 Sep;120(9):1345-53.

 

IncobotulinumtoxinA (Xeomin(®), NT 201) is a purified botulinum toxin type A free from accessory (complexing) proteins. Previous studies evaluated single sets of incobotulinumtoxinA injections for the treatment of blepharospasm. Individualized injection intervals and other potential ...

Last Updated: 26 Aug 2013

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Long-term depression-like plasticity of the blink reflex for the treatment of blepharospasm.
 

Author(s): Gottfried Kranz, Ejaz A Shamim, Peter T Lin, George S Kranz, Mark Hallett

Journal: Mov. Disord.. 2013 Apr;28(4):498-503.

 

Our previous work showed a beneficial therapeutic effect on blepharospasm using slow repetitive transcranial magnetic stimulation, which produces a long-term depression (LTD)-like effect. High-frequency supraorbital electrical stimulation, asynchronous with the R2 component of the ...

Last Updated: 9 Apr 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Blepharospasm" returned 6 free, full-text review articles on human participants. First 3 results:

[Essential blepharospasm: literature review].
 

Author(s): André Gustavo Bombana Nicoletti, Lísia Aoki, Tatiana Rizkallah Nahas, Suzana Matayoshi

Journal: Arq Bras Oftalmol. ;73(5):469-73.

 

Essential blepharospasm is a focal distonia characterized by involuntary, spasmodic, bilateral contractions of eyelid protractors. This is a rare disease, which diagnosis is frequently late and symptoms may progress until functional blindness. In this article, we perform a review ...

Last Updated: 12 Jan 2011

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Difficulties with differentiating botulinum toxin treatment effects in essential blepharospasm.
 

Author(s): Bettina Wabbels, Wolfgang H Jost, Peter Roggenkämper

Journal: J Neural Transm. 2011 Jun;118(6):925-43.

 

Blepharospasm is a focal dystonia in which the extraocular muscles contract repetitively, leading to excessive blinking and forced eyelid closure. Botulinum toxin type A (BoNTA) is the primary symptomatic treatment for blepharospasm and its effects have been evaluated using numerous ...

Last Updated: 31 May 2011

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Update on blepharospasm: report from the BEBRF International Workshop.
 

Author(s): Mark Hallett, Craig Evinger, Joseph Jankovic, Mark Stacy,

Journal: Neurology. 2008 Oct;71(16):1275-82.

 

This review updates understanding and research on blepharospasm, a subtype of focal dystonia. Topics covered include clinical aspects, pathology, pathophysiology, animal models, dry eye, photophobia, epidemiology, genetics, and treatment. Blepharospasm should be differentiated from ...

Last Updated: 14 Oct 2008

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 27 Mar 2014

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Testing the Effect of Zinc Supplementation to Improve the Treatment Effect of Botulinum Toxin for Oculofacial Spasm
 

Status: Not yet recruiting

Condition Summary: Blepharospasm; Hemifacial Spasm

 

Last Updated: 1 Mar 2012

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Acetyl Hexapeptide-8 for Blepharospasm
 

Status: Recruiting

Condition Summary: Focal Dystonia

 

Last Updated: 14 Mar 2014

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