Bladder cancer

Common Name(s)

Bladder cancer

Bladder cancer is a type of cancer that begins in the cells of the bladder, the organ that stores urine. Those affected by bladder cancer may have blood in their urine (hematuria), causing the urine to appear dark yellow, red, or brown. Other symptoms of bladder cancer include a frequent need to urinate, painful urination, and pelvic or back pain.

Bladder cancer occurs when cells in the bladder develop mutations that result in the cells dividing rapidly and resisting death. Those cells form a tumor. Although the cause of bladder cancer is not always known, bladder cancer has been linked to smoking, parasitic infection, and exposure to radiation and chemicals. Other risk factors include previous cancer treatment, taking certain medications for diabetes, repeated bladder infections, and a personal or family history of cancer. White males are more likely to develop bladder cancer than women and individuals of other races. Bladder cancer occurs most often among older individuals.

Bladder cancer may be diagnosed through several methods. A doctor may perform a cystoscopy, a procedure in which a thin tube with a lens is inserted through the urethra to view the bladder lining. During the cystoscopy, a cell sample may be collected using a tool passed through the tube in a procedure called a biopsy. Additionally, a urine sample may be analyzed under a microscope for cancer cells. Imaging tests such as X-ray and computerized tomography (CT) scans can also be used to detect bladder cancer. After diagnosis, a doctor may perform additional tests to determine the stage of cancer.

Treatments for bladder cancer include surgery, immunotherapy, chemotherapy, and, occasionally, radiation therapy. If you have been diagnosed with bladder cancer, talk to your doctor about the most current treatment options. Support groups are available for more resources and information and can connect you with others also diagnosed with bladder cancer.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bladder cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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Bladder Cancer Advocacy Network

To increase public awareness about bladder cancer; to advance bladder cancer research; and to provide educational and support services for the bladder cancer community.

Last Updated: 29 Nov 2013

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Bladder Cancer Support UK

A charity supporting people diagnosed with bladder cancer together with their caters, family and friends. Providing information, increasing awareness and funding research.

Last Updated: 18 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bladder cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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Bladder Cancer Advocacy Network

To increase public awareness about bladder cancer; to advance bladder cancer research; and to provide educational and support services for the bladder cancer community.

http://www.bcan.org/

Last Updated: 29 Nov 2013

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Bladder Cancer Support UK

A charity supporting people diagnosed with bladder cancer together with their caters, family and friends. Providing information, increasing awareness and funding research.

Last Updated: 18 Mar 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bladder cancer" returned 2393 free, full-text research articles on human participants. First 3 results:

Bladder cancer and the Notch pathway.
 

Author(s): Pablo J Fernandez-Marcos, Manuel Serrano, Antonio Maraver

Journal: Oncotarget. 2015 Jan;6(3):1346-7.

 

Last Updated: 16 Feb 2015

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Effect of different Bacillus Calmette-Guerin substrains on growth inhibition of T24 bladder cancer cells and cytokines secretion by BCG activated peripheral blood mononuclear cells of PBMCs.
 

Author(s): Wiesława Janaszek-Seydlitz, Marta Prygiel, Bożena Bucholc, Aldona Wiatrzyk, Urszula Czajka, Paulina Górska, Urszula Soliwoda

Journal: Adv Clin Exp Med. ;23(6):877-84.

 

Bladder carcinoma is the most common malignancy of the urinary tract. Approximately 75-85% of patients present non-muscle invasive bladder cancer (NMIBC). Standard primary treatment for NIMBC is transurethral resection (TUR) followed by intravesical Bacillus Calmette-Guerin (BCG) ...

Last Updated: 27 Jan 2015

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NOTCH pathway inactivation promotes bladder cancer progression.
 

Author(s): Antonio Maraver, Pablo J Fernandez-Marcos, Timothy P Cash, Marinela Mendez-Pertuz, Marta Dueñas, Paolo Maietta, Paola Martinelli, Maribel Muñoz-Martin, Mónica Martínez-Fernández, Marta Cañamero, Giovanna Roncador, Jorge L Martinez-Torrecuadrada, Dimitrios Grivas, Jose Luis de la Pompa, Alfonso Valencia, Jesús M Paramio, Francisco X Real, Manuel Serrano

Journal: J. Clin. Invest.. 2015 Feb;125(2):824-30.

 

NOTCH signaling suppresses tumor growth and proliferation in several types of stratified epithelia. Here, we show that missense mutations in NOTCH1 and NOTCH2 found in human bladder cancers result in loss of function. In murine models, genetic ablation of the NOTCH pathway accelerated ...

Last Updated: 3 Feb 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bladder cancer" returned 228 free, full-text review articles on human participants. First 3 results:

Modelling bladder cancer in mice: opportunities and challenges.
 

Author(s): Takashi Kobayashi, Tomasz B Owczarek, James M McKiernan, Cory Abate-Shen

Journal: Nat. Rev. Cancer. 2015 Jan;15(1):42-54.

 

The prognosis and treatment of bladder cancer have improved little in the past 20 years. Bladder cancer remains a debilitating and often fatal disease, and is among the most costly cancers to treat. The generation of informative mouse models has the potential to improve our understanding ...

Last Updated: 23 Dec 2014

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Thromboembolism and bleeding in bladder cancer.
 

Author(s): Joseph J Fantony, Brant A Inman

Journal: Oncology (Williston Park, N.Y.). 2014 Oct;28(10):847-54.

 

Bladder cancer is a unique disease process in that clinically significant hemorrhage can occur simultaneously with equally significant aberrant clotting. With hematuria the key presenting symptom of bladder cancer, hemorrhage is generally thought to be a component of the natural history ...

Last Updated: 17 Oct 2014

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Safety and efficacy of transurethral laser therapy for bladder cancer: a systematic review and meta-analysis.
 

Author(s): Yunjin Bai, Li Liu, Haichao Yuan, Jinhong Li, Yin Tang, Chunxiao Pu, Ping Han

Journal:

 

Transurethral laser therapy techniques are increasingly being used in the management of bladder tumors. It has reportedly been associated with good outcomes in small case series. The objective of the present study was to review the published literature and compare transurethral laser ...

Last Updated: 1 Oct 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation of Non-Invasive Assay(s) for the Detection of Bladder Cancer
 

Status: Recruiting

Condition Summary: Bladder Cancer; Cancer; Bladder Neoplasms; Urinary Bladder Cancer

 

Last Updated: 30 Mar 2015

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Adjuvant Radiation for High Risk Bladder Cancer
 

Status: Recruiting

Condition Summary: Bladder Cancer; Squamous Cell Carcinoma of the Bladder; Stage III Bladder Cancer; Stage IV Bladder Cancer; Transitional Cell Carcinoma of the Bladder

 

Last Updated: 18 Mar 2015

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Erlotinib Hydrochloride in Treating Patients With Bladder Cancer Undergoing Surgery
 

Status: Recruiting

Condition Summary: Recurrent Bladder Carcinoma; Stage I Bladder Cancer; Stage II Bladder Cancer; Stage III Bladder Cancer

 

Last Updated: 6 May 2015

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