Bladder cancer

Common Name(s)

Bladder cancer

Bladder cancer is a type of cancer that begins in the cells of the bladder, the organ that stores urine. Those affected by bladder cancer may have blood in their urine (hematuria), causing the urine to appear dark yellow, red, or brown. Other symptoms of bladder cancer include a frequent need to urinate, painful urination, and pelvic or back pain.

Bladder cancer occurs when cells in the bladder develop mutations that result in the cells dividing rapidly and resisting death. Those cells form a tumor. Although the cause of bladder cancer is not always known, bladder cancer has been linked to smoking, parasitic infection, and exposure to radiation and chemicals. Other risk factors include previous cancer treatment, taking certain medications for diabetes, repeated bladder infections, and a personal or family history of cancer. White males are more likely to develop bladder cancer than women and individuals of other races. Bladder cancer occurs most often among older individuals.

Bladder cancer may be diagnosed through several methods. A doctor may perform a cystoscopy, a procedure in which a thin tube with a lens is inserted through the urethra to view the bladder lining. During the cystoscopy, a cell sample may be collected using a tool passed through the tube in a procedure called a biopsy. Additionally, a urine sample may be analyzed under a microscope for cancer cells. Imaging tests such as X-ray and computerized tomography (CT) scans can also be used to detect bladder cancer. After diagnosis, a doctor may perform additional tests to determine the stage of cancer.

Treatments for bladder cancer include surgery, immunotherapy, chemotherapy, and, occasionally, radiation therapy. If you have been diagnosed with bladder cancer, talk to your doctor about the most current treatment options. Support groups are available for more resources and information and can connect you with others also diagnosed with bladder cancer.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bladder cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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Bladder Cancer Advocacy Network

To increase public awareness about bladder cancer; to advance bladder cancer research; and to provide educational and support services for the bladder cancer community.

Last Updated: 29 Nov 2013

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Bladder Cancer Support UK

A charity supporting people diagnosed with bladder cancer together with their caters, family and friends. Providing information, increasing awareness and funding research.

Last Updated: 18 Mar 2013

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bladder cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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Bladder Cancer Advocacy Network

To increase public awareness about bladder cancer; to advance bladder cancer research; and to provide educational and support services for the bladder cancer community.

http://www.bcan.org/

Last Updated: 29 Nov 2013

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Bladder Cancer Support UK

A charity supporting people diagnosed with bladder cancer together with their caters, family and friends. Providing information, increasing awareness and funding research.

Last Updated: 18 Mar 2013

View Details
Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bladder cancer" returned 2446 free, full-text research articles on human participants. First 3 results:

Risk groups in bladder cancer patients treated with radical cystectomy.
 

Author(s): Eva Mallen, Pedro Gil, Maria Jesus Gil

Journal: Int Braz J Urol. ;41(1):30-9.

 

To stratify patients with bladder cancer into homogeneous risk groups according to statistically significant differences found in PFS (progression-free survival). To identify those patients at increased risk of progression and to provide oncological follow-up according to patient risk group.

Last Updated: 1 May 2015

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CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer.
 

Author(s): Ming T Cheah, James Y Chen, Debashis Sahoo, Humberto Contreras-Trujillo, Anne K Volkmer, Ferenc A Scheeren, Jens-Peter Volkmer, Irving L Weissman

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2015 Apr;112(15):4725-30.

 

Nonresolving chronic inflammation at the neoplastic site is consistently associated with promoting tumor progression and poor patient outcomes. However, many aspects behind the mechanisms that establish this tumor-promoting inflammatory microenvironment remain undefined. Using bladder ...

Last Updated: 15 Apr 2015

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Morphological and molecular characteristics of HER2 amplified urothelial bladder cancer.
 

Author(s): J Tschui, E Vassella, N Bandi, U Baumgartner, V Genitsch, D Rotzer, R Seiler, G N Thalmann, A Fleischmann

Journal: Virchows Arch.. 2015 Jun;466(6):703-10.

 

Several (pre-) clinical trials are currently investigating the benefit of HER2-targeted therapy in urothelial bladder cancer (UBC). Patients with HER2 amplified UBC could potentially profit from these therapies. However, little is known about histomorphology, HER2 protein expression ...

Last Updated: 9 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bladder cancer" returned 234 free, full-text review articles on human participants. First 3 results:

The promise of novel molecular markers in bladder cancer.
 

Author(s): Jahan Miremami, Natasha Kyprianou

Journal:

 

Bladder cancer is the fourth most common malignancy in the US and is associated with the highest cost per patient. A high likelihood of recurrence, mandating stringent surveillance protocols, has made the development of urinary markers a focus of intense pursuit with the hope of decreasing ...

Last Updated: 23 Dec 2014

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Modelling bladder cancer in mice: opportunities and challenges.
 

Author(s): Takashi Kobayashi, Tomasz B Owczarek, James M McKiernan, Cory Abate-Shen

Journal: Nat. Rev. Cancer. 2015 Jan;15(1):42-54.

 

The prognosis and treatment of bladder cancer have improved little in the past 20 years. Bladder cancer remains a debilitating and often fatal disease, and is among the most costly cancers to treat. The generation of informative mouse models has the potential to improve our understanding ...

Last Updated: 23 Dec 2014

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Current and recent clinical trials for perioperative systemic therapy for muscle invasive bladder cancer: a systematic review.
 

Author(s): Vishal Vashistha, David I Quinn, Tanya B Dorff, Siamak Daneshmand

Journal:

 

Although Muscle Invasive Bladder Cancer (MIBC) is increasing in incidence, treatment has largely remained limited to radical cystectomy with or without cisplatin-based neoadjuvant and/or adjuvant chemotherapy. We reviewed the current and recent clinical trials evaluating perioperative ...

Last Updated: 5 Jan 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation of Non-Invasive Assay(s) for the Detection of Bladder Cancer
 

Status: Recruiting

Condition Summary: Bladder Cancer; Cancer; Bladder Neoplasms; Urinary Bladder Cancer

 

Last Updated: 30 Mar 2015

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Adjuvant Radiation for High Risk Bladder Cancer
 

Status: Recruiting

Condition Summary: Bladder Cancer; Squamous Cell Carcinoma of the Bladder; Stage III Bladder Cancer; Stage IV Bladder Cancer; Transitional Cell Carcinoma of the Bladder

 

Last Updated: 18 Mar 2015

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Erlotinib Hydrochloride in Treating Patients With Bladder Cancer Undergoing Surgery
 

Status: Recruiting

Condition Summary: Recurrent Bladder Carcinoma; Stage I Bladder Cancer; Stage II Bladder Cancer; Stage III Bladder Cancer

 

Last Updated: 6 May 2015

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