Beta Thalassemia

Common Name(s)

Beta Thalassemia, Beta-Thalassemia, Thalassemia Major

Beta-thalassemia is a blood disorder that reduces the production of hemoglobin. Without sufficient hemoglobin, red blood cells do not develop normally, causing a shortage of mature red blood cells, leading to anemia and other health problems. Severe beta-thalassemia is called Òthalassemia majorÓ or ÒCooleyÕs anemia.Ó Thalassemia intermedia is the less severe form. Mutations in the HBB gene cause beta-thalassemia. This condition is usually inherited in an autosomal recessive fashion, which means people with beta thalassemia have mutations in both of their HBB genes. People who have only one HBB mutation may have no symptoms or develop mild symptoms; these individuals are said to have thalassemia minor.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Beta Thalassemia" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Beta Thalassemia" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Beta Thalassemia" returned 775 free, full-text research articles on human participants. First 3 results:

The long-term efficacy and tolerability of oral deferasirox for patients with transfusion-dependent β-thalassemia in Taiwan.
 

Author(s): Hsiu-Hao Chang, Meng-Yao Lu, Steven Shinn-Forng Peng, Yung-Li Yang, Dong-Tsamn Lin, Shiann-Tarng Jou, Kai-Hsin Lin

Journal: Ann. Hematol.. 2015 Dec;94(12):1945-52.

 

Deferasirox is a novel once-daily, oral iron chelator. The aim of this study was to evaluate the long-term efficacy and tolerability of deferasirox in Taiwanese patients with transfusion-dependent β-thalassemia who have been treated with deferasirox for 7 years. Taiwanese patients ...

Last Updated: 14 Oct 2015

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Sehgal index: A new index and its comparison with other complete blood count-based indices for screening of beta thalassemia trait in a tertiary care hospital.
 

Author(s): Kunal Sehgal, Preeti Mansukhani, Tina Dadu, Meher Irani, Shanaz Khodaiji

Journal: Indian J Pathol Microbiol. ;58(3):310-5.

 

Beta thalassemia trait (BTT) must be differentiated from iron deficiency anemia to avoid unnecessary iron therapy and for the prevention of thalassemia major by genetic counseling. In a tertiary care hospital, it is vital that the screening tool is not only sensitive but also specific ...

Last Updated: 15 Aug 2015

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A successful twin pregnancy in a patient with HbE-β-thalassemia in western India.
 

Author(s): R Merchant, K Italia, J Ahmed, K Ghosh, R B Colah

Journal: J Postgrad Med. ;61(3):203-5.

 

Improvements in medical facilities have helped a large number of clinically severe hemoglobin E (HbE)-β-thalassemia patients reach adulthood. Consequently, there is a new challenge, that of managing women with HbE-β-thalassemia during pregnancy. In particular, they have a high risk ...

Last Updated: 29 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Beta Thalassemia" returned 28 free, full-text review articles on human participants. First 3 results:

α-Globin as a molecular target in the treatment of β-thalassemia.
 

Author(s): Sachith Mettananda, Richard J Gibbons, Douglas R Higgs

Journal: Blood. 2015 Jun;125(24):3694-701.

 

The thalassemias, together with sickle cell anemia and its variants, are the world's most common form of inherited anemia, and in economically undeveloped countries, they still account for tens of thousands of premature deaths every year. In developed countries, treatment of thalassemia ...

Last Updated: 13 Jun 2015

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Endocrine and bone complications in β-thalassemia intermedia: current understanding and treatment.
 

Author(s): Adlette Inati, MohammadHassan A Noureldine, Anthony Mansour, Hussein A Abbas

Journal: Biomed Res Int. 2015 ;2015():813098.

 

Thalassemia intermedia (TI), also known as nontransfusion dependent thalassemia (NTDT), is a type of thalassemia where affected patients do not require lifelong regular transfusions for survival but may require occasional or even frequent transfusions in certain clinical settings ...

Last Updated: 2 Apr 2015

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[Advances in pathogenesis and correlated clinical research of hypercoagulability in β thalassemia].
 

Author(s): Rong-Yu Lv, Fei-Qiu Wen, Jie Yu

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Jul;16(7):774-8.

 

This article summarizes the pathogenesis of hypercoagulability in β thalassemia patients, including platelet activation, alteration of red blood cell membranes, abnormal expression of adhesion molecules on vascular endothelial cells and iron overload. Clinical evidence, clinical ...

Last Updated: 10 Jul 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gene Therapy for Transfusion Dependent Beta-thalassemia
 

Status: Recruiting

Condition Summary: Beta-Thalassemia

 

Last Updated: 21 Jun 2016

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An Algorithm to Start Iron Chelation in Minimally Transfused Young Beta-thalassemia Major Patients
 

Status: Not yet recruiting

Condition Summary: Beta Thalassemia Major

 

Last Updated: 13 Jan 2015

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