Beckwith-Wiedemann Syndrome

Common Name(s)

Beckwith-Wiedemann Syndrome

Beckwith-Wiedemann syndrome is a growth disorder that causes large body size, large organs, and other symptoms. The condition is present from birth. Newborns may be born with omphalocele and/or develop low blood sugar (hypoglycemia). Beckwith-Wiedemann syndrome is also associated with an increased rate of tumor (e.g., Wilm's tumor, adrenal carcinoma) development. Complications in infancy can become life threatening, however children with this syndrome tend to do well and have a normal to near normal learning ability. In most cases the cause of the condition is unknown. Some cases are associated with a anomaly involving chromosome 11.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Beckwith-Wiedemann Syndrome" for support, advocacy or research.

Beckwith-Wiedemann Children's Foundation

The Beckwith-Wiedemann Children's Foundation is a non-profit organization dedicated to increasing the quality of life for those affected by this rare, 1:14,000 birth disorder.

Last Updated: 1 Nov 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Beckwith-Wiedemann Syndrome" for support, advocacy or research.

Beckwith-Wiedemann Children's Foundation

The Beckwith-Wiedemann Children's Foundation is a non-profit organization dedicated to increasing the quality of life for those affected by this rare, 1:14,000 birth disorder.

http://www.beckwith-wiedemannsyndrome.org

Last Updated: 1 Nov 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Beckwith-Wiedemann Syndrome" returned 100 free, full-text research articles on human participants. First 3 results:

Pancreatic surgery in infants with Beckwith-Wiedemann syndrome and hyperinsulinism.
 

Author(s): Pablo Laje, Andrew A Palladino, Tricia R Bhatti, Lisa J States, Charles A Stanley, N Scott Adzick

Journal: J. Pediatr. Surg.. 2013 Dec;48(12):2511-6.

 

To present our experience in the care of infants with Beckwith-Wiedemann syndrome (BWS) who required pancreatectomy for the management of severe Congenital Hyperinsulinism (HI).

Last Updated: 9 Dec 2013

Go To URL
Quantitative DNA methylation analysis improves epigenotype-phenotype correlations in Beckwith-Wiedemann syndrome.
 

Author(s): Mariarosaria Calvello, Silvia Tabano, Patrizia Colapietro, Silvia Maitz, Alessandra Pansa, Claudia Augello, Faustina Lalatta, Barbara Gentilin, Filippo Spreafico, Luciano Calzari, Daniela Perotti, Lidia Larizza, Silvia Russo, Angelo Selicorni, Silvia M Sirchia, Monica Miozzo

Journal: Epigenetics. 2013 Oct;8(10):1053-60.

 

Beckwith-Wiedemann syndrome (BWS) is a rare disorder characterized by overgrowth and predisposition to embryonal tumors. BWS is caused by various epigenetic and/or genetic alterations that dysregulate the imprinted genes on chromosome region 11p15.5. Molecular analysis is required ...

Last Updated: 19 Dec 2013

Go To URL
Large offspring syndrome: a bovine model for the human loss-of-imprinting overgrowth syndrome Beckwith-Wiedemann.
 

Author(s): Zhiyuan Chen, Katherine Marie Robbins, Kevin Dale Wells, Rocío Melissa Rivera

Journal: Epigenetics. 2013 Jun;8(6):591-601.

 

Beckwith-Wiedemann syndrome (BWS) is a human loss-of-imprinting syndrome primarily characterized by macrosomia, macroglossia, and abdominal wall defects. BWS has been associated with misregulation of two clusters of imprinted genes. Children conceived with the use of assisted reproductive ...

Last Updated: 9 Sep 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Beckwith-Wiedemann Syndrome" returned 9 free, full-text review articles on human participants. First 3 results:

Adrenal masses associated with Beckwith Wiedemann syndrome in the newborn.
 

Author(s): Devendra V Taide, Pradnya S Bendre, Rajeev Redkar, Sandeep Hambarde

Journal: Afr J Paediatr Surg. ;7(3):209-10.

 

Adrenal cystic lesions are rare and may be associated with both complete and incomplete Beckwith syndrome (BWS). Because the adrenal gland often houses malignant lesions, differentiation between benign and malignant lesions of the gland, although usually difficult, is very necessary ...

Last Updated: 22 Sep 2010

Go To URL
Beckwith-Wiedemann syndrome.
 

Author(s): Rosanna Weksberg, Cheryl Shuman, J Bruce Beckwith

Journal: Eur. J. Hum. Genet.. 2010 Jan;18(1):8-14.

 

Beckwith-Wiedemann syndrome (BWS) is a model disorder for the study of imprinting, growth dysregulation, and tumorigenesis. Unique observations in this disorder point to an important embryonic developmental window relevant to the observations of increased monozygotic twinning and ...

Last Updated: 16 Dec 2009

Go To URL
Beckwith-Wiedemann syndrome and isolated hemihyperplasia.
 

Author(s): Marcus Vinícius de Matos Gomes, Ester Silveira Ramos

Journal: Sao Paulo Med J. 2003 May;121(3):133-8.

 

Beckwith-Wiedemann syndrome is a complex and heterogeneous overgrowth syndrome with genetic and epigenetic alterations, involving genomic imprinting and cancer predisposition. Isolated hemihyperplasia is of unknown cause, and it may represent a partial or incomplete expression of ...

Last Updated: 15 Aug 2003

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic Hypoglycemia
 

Status: Available

Condition Summary: Congenital Hyperinsulinism; Beckwith-Wiedemann Syndrome; Insulinoma

 

Last Updated: 5 Feb 2014

Go to URL
Prenatal Screening for Imprinting Anomalies Implicated in Beckwith Wiedemann and Silver Russell Syndromes
 

Status: Recruiting

Condition Summary: Pregnant Women Requiring Amniocentesis

 

Last Updated: 14 Nov 2013

Go to URL
Genomic Imprinting and Assisted Reproductive Technologies
 

Status: Recruiting

Condition Summary: Natural Pregnancy; Pregnancy, Ovarian

 

Last Updated: 4 Mar 2014

Go to URL