Becker Muscular Dystrophy

Common Name(s)

Becker Muscular Dystrophy

Becker muscular dystrophy is an inherited disorder that involves slowly worsening muscle weakness of the legs and pelvis.  It is caused by a mutation in a gene called the DMD gene, which encodes the muscle protein dystrophin. The disorder is inherited in an X-linked recessive manner. Becker muscular dystrophy is very similar to Duchenne muscular dystrophy, except that symptoms develop at a later age and progress at a much slower rate. In addition to the skeletal muscles used for movement, Becker muscular dystrophy may also affect the muscles of the heart. There is no known cure for this condition. Treatment tries to control symptoms to maximize quality of life.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Becker Muscular Dystrophy" for support, advocacy or research.

Neuromuscular Disease Association of China

There are over 40 different types of Muscular Dystrophy and related Neuromuscular conditions.These conditions are characterised by loss of muscular strength,as progressive muscle wasting or nerve

http://www.mdachina.org

Last Updated: 21 May 2010

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Parent Project Muscular Dystrophy

Parent Project Muscular Dystrophy’s mission is to end Duchenne. We accelerate research, raise our voices in Washington, demand optimal care for all young men, and educate the global community.

http://www.parentprojectmd.org

Last Updated: 15 Nov 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Becker Muscular Dystrophy" for support, advocacy or research.

Neuromuscular Disease Association of China

There are over 40 different types of Muscular Dystrophy and related Neuromuscular conditions.These conditions are characterised by loss of muscular strength,as progressive muscle wasting or nerve

http://www.mdachina.org

Last Updated: 21 May 2010

View Details
Parent Project Muscular Dystrophy

Parent Project Muscular Dystrophy’s mission is to end Duchenne. We accelerate research, raise our voices in Washington, demand optimal care for all young men, and educate the global community.

http://www.parentprojectmd.org

Last Updated: 15 Nov 2012

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Becker Muscular Dystrophy" returned 107 free, full-text research articles on human participants. First 3 results:

Brain natriuretic peptide is not predictive of dilated cardiomyopathy in Becker and Duchenne muscular dystrophy patients and carriers.
 

Author(s): Steven Schade van Westrum, Lukas Dekker, Rob de Haan, Erik Endert, Ieke Ginjaar, Marianne de Visser, Anneke van der Kooi

Journal:

 

Cardiomyopathy is reported in Duchenne and Becker muscle dystrophy patients and female carriers. Brain Natriuretic peptide (BNP) is a hormone produced mainly by ventricular cardiomyocytes and its production is up regulated in reaction to increased wall stretching. N-terminal-proBNP ...

Last Updated: 22 Jul 2013

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Cardiac resynchronization therapy in becker muscular dystrophy.
 

Author(s): George Andrikopoulos, Spiros Kourouklis, Chrysanthi Trika, Stylianos Tzeis, Ioannis Rassias, Christos Papademetriou, Apostolos Katsivas, George Theodorakis

Journal: Hellenic J Cardiol. ;54(3):227-9.

 

A 44-year-old male patient with known Becker muscular dystrophy and concomitant non-ischemic dilated cardiomyopathy presented to our department because of worsening heart failure and presyncope. Upon admission, the patient was in New York Heart Association functional class III despite ...

Last Updated: 20 May 2013

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Rimmed vacuoles in Becker muscular dystrophy have similar features with inclusion myopathies.
 

Author(s): Kazunari Momma, Satoru Noguchi, May Christine V Malicdan, Yukiko K Hayashi, Narihiro Minami, Keiko Kamakura, Ikuya Nonaka, Ichizo Nishino

Journal: PLoS ONE. 2012 ;7(12):e52002.

 

Rimmed vacuoles in myofibers are thought to be due to the accumulation of autophagic vacuoles, and can be characteristic in certain myopathies with protein inclusions in myofibers. In this study, we performed a detailed clinical, molecular, and pathological characterization of Becker ...

Last Updated: 19 Dec 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Becker Muscular Dystrophy" returned 5 free, full-text review articles on human participants. First 3 results:

Read-through strategies for suppression of nonsense mutations in Duchenne/ Becker muscular dystrophy: aminoglycosides and ataluren (PTC124).
 

Author(s): Richard S Finkel

Journal: J. Child Neurol.. 2010 Sep;25(9):1158-64.

 

Nucleotide changes within an exon can alter the trinucleotide normally encoding a particular amino acid, such that a new ''stop'' signal is transcribed into the mRNA open reading frame. This causes the ribosome to prematurely terminate its reading of the mRNA, leading to nonsense-mediated ...

Last Updated: 6 Sep 2010

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Current understanding and management of dilated cardiomyopathy in Duchenne and Becker muscular dystrophy.
 

Author(s): Rita Wen Kaspar, Hugh D Allen, Federica Montanaro

Journal: J Am Acad Nurse Pract. 2009 May;21(5):241-9.

 

To review the current understanding of the pathophysiology of dilated cardiomyopathy (DCM) in patients with Duchenne and Becker muscular dystrophies, assessment of cardiac dysfunction for these patients, and the recommended pharmacological treatment options and ongoing research directions.

Last Updated: 12 May 2009

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Cardiac involvement in Becker muscular dystrophy.
 

Author(s): Josef Finsterer, Claudia Stöllberger

Journal: Can J Cardiol. 2008 Oct;24(10):786-92.

 

The present review gives an overview of the clinical and subclinical manifestations of cardiac involvement (CI) in Becker muscular dystrophy (BMD), its pathophysiological background, diagnostic possibilities and therapeutic options for CI in BMD patients and carriers. CI may be subclinical ...

Last Updated: 8 Oct 2008

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ramipril Versus Carvedilol in Duchenne and Becker Patients
 

Status: Recruiting

Condition Summary: Duchenne Muscular Dystrophy; Becker Muscular Dystrophy

 

Last Updated: 8 Jan 2009

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Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study)
 

Status: Recruiting

Condition Summary: Becker Muscular Dystrophy

 

Last Updated: 23 Aug 2013

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DuchenneConnect Registry
 

Status: Recruiting

Condition Summary: Duchenne Muscular Dystrophy; Becker Muscular Dystrophy

 

Last Updated: 20 Feb 2014

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