Bartter's Syndrome

Common Name(s)

Bartter's Syndrome, Bartter Syndrome

Bartter syndrome is a group of similar kidney disorders that cause an imbalance of potassium, sodium, chloride, and other molecules in the body. In some cases, the condition manifests before birth with increased amniotic fluid surrounding the affected fetus (polyhydramnios). Affected infants typically do not grow and gain wait as expected. Dehydration, constipation and increased urine production result from losing too much salt (sodium chloride) in the urine, and weakening of the bones can occur due to excess loss of calcium. Low levels of potassium in the blood (hypokalemia) can cause muscle weakness, cramping, and fatigue. It is caused by mutations in any one of at least 5 genes and is inherited in an autosomal recessive manner. The different types of Bartter syndrome are classified according to the specific gene that causes the condition. Treatment depends on the type of the syndrome present but chiefly focuses on preventing the loss of too much potassium from the body.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bartter's Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bartter's Syndrome" returned 55 free, full-text research articles on human participants. First 3 results:

Application of molecular biology at the approach of Bartter's syndrome: case report.
 

Author(s): Geisilaine Soares Dos Reis, Débora Marques de Miranda, Paula Cristina de Barros Pereira, Helena Cunha Sarubi, Luciana Bastos Rodrigues, Luiz Armando Cunha de Marco, Ana Cristina Simões E Silva

Journal: J Bras Nefrol. 2012 Mar;34(1):82-6.

 

This paper aims to show the utility of molecular biology for diagnose Bartter syndrome (BS) by the case report of two sisters and to propose a diagram for the molecular approach of this syndrome. The two reported cases presented prematurity, pregnancy complicated with polyhydramnio ...

Last Updated: 23 Mar 2012

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Gouty arthritis in a 15-year-old girl with Bartter's syndrome.
 

Author(s): Nima Derakhshan, Dorna Derakhshan, Mitra Basiratnia, Mohammad Hossein Fallahzadeh, Ghamar Hashemi, Ali Derakhshan

Journal: Saudi J Kidney Dis Transpl. 2010 Nov;21(6):1129-31.

 

A 15-year-old girl, a known case of Bartter's syndrome (BS) for 7 years, developed severe pain in her right knee and right and left ankle. Her older sister had BS and developed end-stage renal disease (ESRD) at the age of 14 years. Her serum uric acid was 12.6 mg/dL, 6 months ago, ...

Last Updated: 9 Nov 2010

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Analysis of claudin genes in pediatric patients with Bartter's syndrome.
 

Author(s): Yan-Hua Chen, Jen-Jar Lin, Beverly G Jeansonne, Rodney Tatum, Qun Lu

Journal: Ann. N. Y. Acad. Sci.. 2009 May;1165():126-34.

 

Bartter's syndrome is a constellation of symptoms characterized by hyper-reninemic hypokalemia, metabolic alkalosis, elevated renin and aldosterone, low or normal blood pressure, and hyperplasia of the juxtaglomerular apparatus. So far, five gene mutations in proteins regulating the ...

Last Updated: 22 Jun 2009

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bartter's Syndrome" returned 1 free, full-text review articles on human participants. First 3 results:

Anesthetic management of a patient with Bartter's syndrome undergoing orthognathic surgery.
 

Author(s): J A Roelofse, A J van der Westhuijzen

Journal: Anesth Prog. 1997 ;44(2):71-5.

 

Bartter's syndrome is a rare disorder characterized by severe hypokalemic alkalosis, marked elevation in plasma renin activity, pressor insensitivity to angiotensin II, and normal or low values of plasma sodium, plasma chloride, and blood pressure. Many of the clinical features and ...

Last Updated: 31 Mar 1998

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Parathyroid Hormone (PTH) Homeostasis in Bartter Syndrome
 

Status: Not yet recruiting

Condition Summary: Hypocalcemia; Hypercalcemia

 

Last Updated: 13 Jun 2012

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A Translational Approach to Gitelman Syndrome
 

Status: Not yet recruiting

Condition Summary: Gitelman Syndrome

 

Last Updated: 13 Jan 2009

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