Bartter's Syndrome

Common Name(s)

Bartter's Syndrome, Bartter Syndrome

Bartter syndrome is a group of similar kidney disorders that cause an imbalance of potassium, sodium, chloride, and other molecules in the body. In some cases, the condition manifests before birth with increased amniotic fluid surrounding the affected fetus (polyhydramnios). Affected infants typically do not grow and gain wait as expected. Dehydration, constipation and increased urine production result from losing too much salt (sodium chloride) in the urine, and weakening of the bones can occur due to excess loss of calcium. Low levels of potassium in the blood (hypokalemia) can cause muscle weakness, cramping, and fatigue. It is caused by mutations in any one of at least 5 genes and is inherited in an autosomal recessive manner. The different types of Bartter syndrome are classified according to the specific gene that causes the condition. Treatment depends on the type of the syndrome present but chiefly focuses on preventing the loss of too much potassium from the body.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bartter's Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bartter's Syndrome" returned 61 free, full-text research articles on human participants. First 3 results:

The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype.
 

Author(s): Caryn Hampton, Xiaoyan Zhou, Birgit T Priest, Lee-Yuh Pai, John P Felix, Brande Thomas-Fowlkes, Jessica Liu, Martin Kohler, Jianying Xiao, Aaron Corona, Olga Price, Charles Gill, Kashmira Shah, Cordelia Rasa, Vince Tong, Karen Owens, James Ormes, Haifeng Tang, Sophie Roy, Kathleen A Sullivan, Joseph M Metzger, Magdalena Alonso-Galicia, Gregory J Kaczorowski, Alexander Pasternak, Maria L Garcia

Journal: J. Pharmacol. Exp. Ther.. 2016 Oct;359(1):194-206.

 

The renal outer medullary potassium (ROMK) channel, located at the apical surface of epithelial cells in the thick ascending loop of Henle and cortical collecting duct, contributes to salt reabsorption and potassium secretion, and represents a target for the development of new mechanism ...

Last Updated: 16 Sep 2016

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Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations.
 

Author(s): Kamel Laghmani, Bodo B Beck, Sung-Sen Yang, Elie Seaayfan, Andrea Wenzel, Björn Reusch, Helga Vitzthum, Dario Priem, Sylvie Demaretz, Klasien Bergmann, Leonie K Duin, Heike Göbel, Christoph Mache, Holger Thiele, Malte P Bartram, Carlos Dombret, Janine Altmüller, Peter Nürnberg, Thomas Benzing, Elena Levtchenko, Hannsjörg W Seyberth, Günter Klaus, Gökhan Yigit, Shih-Hua Lin, Albert Timmer, Tom J de Koning, Sicco A Scherjon, Karl P Schlingmann, Mathieu J M Bertrand, Markus M Rinschen, Olivier de Backer, Martin Konrad, Martin Kömhoff

Journal: N. Engl. J. Med.. 2016 May;374(19):1853-63.

 

Three pregnancies with male offspring in one family were complicated by severe polyhydramnios and prematurity. One fetus died; the other two had transient massive salt-wasting and polyuria reminiscent of antenatal Bartter's syndrome.

Last Updated: 12 May 2016

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Application of molecular biology at the approach of Bartter's syndrome: case report.
 

Author(s): Geisilaine Soares Dos Reis, Débora Marques de Miranda, Paula Cristina de Barros Pereira, Helena Cunha Sarubi, Luciana Bastos Rodrigues, Luiz Armando Cunha de Marco, Ana Cristina Simões E Silva

Journal: J Bras Nefrol. 2012 Mar;34(1):82-6.

 

This paper aims to show the utility of molecular biology for diagnose Bartter syndrome (BS) by the case report of two sisters and to propose a diagram for the molecular approach of this syndrome. The two reported cases presented prematurity, pregnancy complicated with polyhydramnio ...

Last Updated: 23 Mar 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bartter's Syndrome" returned 2 free, full-text review articles on human participants. First 3 results:

Anesthetic management of a patient with Bartter's syndrome undergoing orthognathic surgery.
 

Author(s): J A Roelofse, A J van der Westhuijzen

Journal: Anesth Prog. 1997 ;44(2):71-5.

 

Bartter's syndrome is a rare disorder characterized by severe hypokalemic alkalosis, marked elevation in plasma renin activity, pressor insensitivity to angiotensin II, and normal or low values of plasma sodium, plasma chloride, and blood pressure. Many of the clinical features and ...

Last Updated: 31 Mar 1998

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Prostaglandins and Bartter's syndrome.
 

Author(s): M J Dunn

Journal: Kidney Int.. 1981 Jan;19(1):86-102.

 

Last Updated: 25 Jun 1981

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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