Attenuated Familial Adenomatous Polyposis (AFAP)

Common Name(s)

Attenuated Familial Adenomatous Polyposis (AFAP), Attenuated FAP

Attenuated familial adenomatous polyposis (AFAP) is a cancer predisposition syndrome characterized by a significant risk to develop colon cancer. Individuals with AFAP generally have fewer colon polyps (an average of 30) than in classic FAP, and the polyps tend to occur more proximally in the colon. The average age of colon cancer diagnosis in affected individuals is 50 to 55 years, which is 10 to 15 years later than in those with classic FAP, but earlier than when colon cancer occurs in the general population. In addition to colon polyps, findings may include upper gastrointestinal polyps and cancers; non-intestine related signs of FAP (but CHRPE and desmoid tumors are rare); and thyroid cancer. AFAP is caused by mutations in the APC gene and is inherited in an autosomal dominant manner.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Attenuated Familial Adenomatous Polyposis (AFAP)" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
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Reviews from the PubMed Database

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The terms "Attenuated Familial Adenomatous Polyposis (AFAP)" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.