Atrial fibrillation, familial, 1

Common Name(s)

Atrial fibrillation, familial, 1

Atrial fibrillation (AF) is the most common sustained cardiac rhythm disturbance, affecting more than 2 million Americans, with an overall prevalence of 0.89%. The prevalence increases rapidly with age, to 2.3% between the ages of 40 and 60 years, and to 5.9% over the age of 65. The most dreaded complication is thromboembolic stroke ({1:Brugada et al., 1997}). Genetic Heterogeneity of Familial Atrial Fibrillation ATFB1 shows linkage to chromosome 10q22-q24. ATFB2 ({608988}) maps to chromosome 6q. ATFB3 ({607554}) is caused by mutation in the KCNQ1 gene ({607542}) on chromosome 11. ATFB4 ({611493}) is caused by mutation in the KCNE2 gene ({603796}) on chromosome 21. Variants in a region of chromosome 4q25 are associated with ATFB5 ({611494}). ATFB6 ({612201}) is caused by mutation in the NPPA gene ({108780}) on chromosome 1p36. ATFB7 ({612240}) is caused by mutation in the KCNA5 gene ({176267}) on chromosome 12p13. ATFB8 ({613055}) maps to chromosome 16q22. ATFB9 ({613980}) is caused by mutation in the KCNJ2 gene ({600681}) on chromosome 17q24.3. ATFB10 ({614022}) is caused by mutation in the SCN5A gene ({600163}) on chromosome 3p21. ATFB11 ({614049}) is caused by mutation in the GJA5 ({121013}) gene on chromosome 1q21.1. ATFB12 ({614050}) is caused by mutation in the ABCC9 gene ({601439}) on chromosome 12p12.1. ATFB13 ({615377}) is caused by mutation in the SCN1B gene ({600235}) on chromosome 19q13. ATFB14 ({615378}) is caused by mutation in the SCN2B gene ({601327}) on chromosome 11q23. ATFB15 ({615770}) is caused by mutation in the NUP155 gene ({606694}) on chromosome 5p13. {4:Olesen et al. (2014)} analyzed 192 Danish Caucasian patients with onset of lone atrial fibrillation before the age of 40 years for the presence of rare variants in 14 AF-associated genes and found that 29 (7.6%) alleles harbored a very rare variant (minor allele frequency less than 1%), a significantly higher percentage than that found in 6,503 individuals in the NHLBI Exome Variant Server database (4.1%; p = 0.0012). Twenty-four of the 29 rare variants found in the lone AF patient cohort had previously been studied, with 23 (96%) showing abnormal ion channel function by patch-clamp analysis. {4:Olesen et al. (2014)} suggested that rare variants in AF susceptibility genes may play a role in the pathophysiology of AF.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Atrial fibrillation, familial, 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Atrial fibrillation, familial, 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Atrial fibrillation, familial, 1" returned 0 free, full-text research articles on human participants.

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Atrial fibrillation, familial, 1" returned 0 free, full-text review articles on human participants.

 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.