Aortic valve disorder

Common Name(s)

Aortic valve disorder

Bicuspid, or bicommissural, aortic valve (BAV) describes an aortic valve with 2 rather than 3 leaflets ({3:Cripe et al., 2004}). In 1 to 2% of the population a bicuspid aortic valve is present. Bicuspid aortic valve is frequently an antecedent to aortic valve stenosis or insufficiency. In extreme cases the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome ({241550}) ({5:Garg et al., 2005}). The valve calcification often observed in bicuspid aortic valve is a result of inappropriate activation of osteoblast-specific gene expression. Mutations in the signaling and transcription regulator NOTCH1 cause a spectrum of developmental aortic valve anomalies and severe valve calcification in nonsyndromic autosomal dominant human pedigrees. Genetic Heterogeneity of Aortic Valve Disease Aortic valve disease-2 (AOVD2; {614823}) is caused by mutation in the SMAD6 gene ({602931}) on chromosome 15q22. There is evidence for additional genetic heterogeneity (see MAPPING).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aortic valve disorder" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Aortic valve disorder" returned 0 free, full-text research articles on human participants.

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The terms "Aortic valve disorder" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 3 Mar 2014

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Comparison of the Local Anaesthetics Articaine and Bupivacaine in Treatment of Acute Sternum Pain After Heart Surgery
 

Status: Recruiting

Condition Summary: Diseases of Mitral Valve; Aortic Valve Disorder; Atrial Septal Defects; Intracardiac Myxoma

 

Last Updated: 8 Oct 2014

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Phase III Study Comparing Two Methods of Cardioplegia in Aortic Valve Surgery Custodiol-N Versus Custodiol
 

Status: Recruiting

Condition Summary: Aortic Valve Disease; Coronary Artery Disease (CAD)

 

Last Updated: 10 Jun 2014

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