Aortic valve disorder

Common Name(s)

Aortic valve disorder

Bicuspid, or bicommissural, aortic valve (BAV) describes an aortic valve with 2 rather than 3 leaflets ({3:Cripe et al., 2004}). In 1 to 2% of the population a bicuspid aortic valve is present. Bicuspid aortic valve is frequently an antecedent to aortic valve stenosis or insufficiency. In extreme cases the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome ({241550}) ({5:Garg et al., 2005}). The valve calcification often observed in bicuspid aortic valve is a result of inappropriate activation of osteoblast-specific gene expression. Mutations in the signaling and transcription regulator NOTCH1 cause a spectrum of developmental aortic valve anomalies and severe valve calcification in nonsyndromic autosomal dominant human pedigrees. Genetic Heterogeneity of Aortic Valve Disease Aortic valve disease-2 (AOVD2; {614823}) is caused by mutation in the SMAD6 gene ({602931}) on chromosome 15q22. There is evidence for additional genetic heterogeneity (see MAPPING).
 

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Condition Specific Organizations

Following organizations serve the condition "Aortic valve disorder" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Aortic valve disorder" returned 2 free, full-text research articles on human participants. First 3 results:

David valve-sparing aortic root replacement: equivalent mid-term outcome for different valve types with or without connective tissue disorder.
 

Author(s): John-Peder Escobar Kvitting, Fabian A Kari, Michael P Fischbein, David H Liang, Anne-Sophie Beraud, Elizabeth H Stephens, R Scott Mitchell, D Craig Miller

Journal: J. Thorac. Cardiovasc. Surg.. 2013 Jan;145(1):117-26, 127.e1-5; discussion 126-7.

 

Although implicitly accepted by many that the durability of valve-sparing aortic root replacement in patients with bicuspid aortic valve disease and connective tissue disorders will be inferior, this hypothesis has not been rigorously investigated.

Last Updated: 18 Dec 2012

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Valve-sparing aortic root replacement in a patient with a rare connective tissue disorder: arterial tortuosity syndrome.
 

Author(s): Tomaso Bottio, Gianluigi Bisleri, Paolo Piccoli, Claudio Muneretto

Journal: J. Thorac. Cardiovasc. Surg.. 2007 Jan;133(1):252-3.

 

Last Updated: 2 Jan 2007

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Aortic valve disorder" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 12 Mar 2015

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Last Updated: 19 Sep 2016

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Combined Transcatheter Aortic Valve Implantation and Percutaneous Closure of the Left Atrial Appendage
 

Status: Not yet recruiting

Condition Summary: Aortic Valve Disorder

 

Last Updated: 11 Mar 2016

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