Ankylosing spondylitis

Common Name(s)

Ankylosing spondylitis, AS, Bechterew disease, Marie Strumpell disease

Ankylosing spondylitis (AS) is an inflammatory joint disease that primarily affects the spine. As ankylosing spondylitis progresses, the vertebrae in the spine fuse together (ankylosis), causing the spine to be less flexible and may result in a hunched-forward posture. Signs and symptoms of ankylosing spondylitis may include pain and stiffness in your lower back and hips. Affected areas can include the joints between the base of your spine and pelvis, the joints between the vertebrae, the hip joints, and the shoulder joints.

Up to 40 percent of individuals with ankylosing spondylitis will have eye inflammation that may cause eye pain, sensitivity to light and blurred vision. Other less common complications include restricted lung function and heart inflammation. Risk factors of ankylosing spondylitis include gender and age, as men develop ankylosing spondylitis more often than women and onset of symptoms typically occurs in late adolescence and early adulthood. The exact cause of ankylosing spondylitis is unknown, but it is believed that both genetic and environmental factors play a role. One genetic factor is the HLA-B gene, which provides instructions for making a protein that helps the immune system distinguish the body’s own proteins from foreign invaders (such as viruses and bacteria). Individuals who have the HLA-B27 variation of the HLA-B gene are at greater risk of developing ankylosing spondylitis.

Your doctor may use a physical exam along with imaging tests and lab tests to diagnosis the condition. There is no cure for ankylosing spondylitis, but there are treatment options that can help decrease your pain and reduce your symptoms. Support groups are good resources for additional information. Contact a doctor if you or someone in your family has been diagnosed with ankylosing spondylitis to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing spondylitis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

View Details
Logo
Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

Last Updated: 24 Nov 2009

View Details
stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing spondylitis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

View Details
Logo
Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

http://www.kickas.org

Last Updated: 24 Nov 2009

View Details
stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ankylosing spondylitis" returned 1370 free, full-text research articles on human participants. First 3 results:

[Clinical analysis of 31 ankylosing spondylitis patients with malignancies].
 

Author(s): Lan Gao, Yong Fan, Zhuo-li Zhang

Journal: Beijing Da Xue Xue Bao. 2015 Dec;47(6):962-5.

 

To investigate the clinical features of patients with ankylosing spondylitis (AS) and malignancies.

Last Updated: 18 Dec 2015

Go To URL
Audiovestibular Manifestations in Patients with Ankylosing Spondylitis--A Case Report and Review of the Literature.
 

Author(s): Ahmet Koç, İsmet Emrah Emre

Journal: J Int Adv Otol. 2015 Aug;11(2):176-8.

 

Ankylosing spondylitis is a chronic systemic inflammatory disease of unknown origin affecting up to 1% of the population. Audiovestibular impairment has been observed in ankylosing spondylitis and sensorineural hearing loss (SNHL) is the most common form. The cause of SNHL is still ...

Last Updated: 19 Sep 2015

Go To URL
Predictors of response and drug survival in ankylosing spondylitis patients treated with infliximab.
 

Author(s): Mariagrazia Lorenzin, Augusta Ortolan, Paola Frallonardo, Francesca Oliviero, Leonardo Punzi, Roberta Ramonda

Journal:

 

The advent of anti-tumor necrosis factor-α (TNFα) drugs has changed the course of ankylosing spondylitis (AS). While data are available concerning the long term effectiveness of single anti-TNF agents, little has been published about predictors of treatment response in AS. The aim ...

Last Updated: 24 Jul 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ankylosing spondylitis" returned 93 free, full-text review articles on human participants. First 3 results:

Inflammatory pseudotumor around metal-on-polyethylene total hip arthroplasty in patients with ankylosing spondylitis: description of two cases and review of literature.
 

Author(s): Dong Fu, Wei Sun, Jiakang Shen, Xiaojun Ma, Zhengdong Cai, Yingqi Hua

Journal:

 

Inflammatory pseudotumor has been commonly reported in patients undertaking total hip replacement (THR) for different reasons. The precise etiology of this biological reaction and whether the primary disease has an influence on pseudotumor formation remain unclear. There seems to ...

Last Updated: 19 Apr 2015

Go To URL
Spanish Rheumatology Society and Hospital Pharmacy Society Consensus on recommendations for biologics optimization in patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis.
 

Author(s): Isidoro González-Álvaro, Carmen Martínez-Fernández, Benito Dorantes-Calderón, Rosario García-Vicuña, Blanca Hernández-Cruz, Alicia Herrero-Ambrosio, Olatz Ibarra-Barrueta, Emilio Martín-Mola, Emilio Monte-Boquet, Alberto Morell-Baladrón, Raimon Sanmartí, Jesús Sanz-Sanz, Francisco Javier de Toro-Santos, Paloma Vela, José Andrés Román Ivorra, José Luis Poveda-Andrés, Santiago Muñoz-Fernández, ,

Journal: Rheumatology (Oxford). 2015 Jul;54(7):1200-9.

 

The aim of this study was to establish guidelines for the optimization of biologic therapies for health professionals involved in the management of patients with RA, AS and PsA.

Last Updated: 20 Jun 2015

Go To URL
[Genetics of ankylosing spondylitis].
 

Author(s): Patricia Castro-Santos, Miguel A Gutiérrez, Roberto Díaz-Peña

Journal: Rev Med Chil. 2014 Sep;142(9):1165-73.

 

Ankylosing spondylitis (AS) is a prototypical inflammatory disease of the locomotor system affecting axial skeleton. It is part of the general group of spondyloarthopathies (SpA). Its strong association with histocompatibility antigen HLA-B27 is known since 1973. However, HLA-B27 ...

Last Updated: 18 Dec 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

European Ankylosing Spondylitis Infliximab Cohort (EASIC) Follow up Registration Study
 

Status: Not yet recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 27 Jan 2011

Go to URL
Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study
 

Status: Recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 21 Jan 2016

Go to URL