Ankylosing Spondylitis

Common Name(s)

Ankylosing Spondylitis

Ankylosing spondylitis is a type of arthritis of the spine. It causes swelling between the vertebrae and in the joints between the spine and pelvis. This autoimmune disease is more common and more severe in men than in women.  It is likely caused by a combination of genetic and environmental factors, most of which have not yet been identified. Researchers have found variations in several genes that influence the risk of developing this disorder. These genes include HLA-B, ERAP1, IL1A, and IL23R. Early symptoms of ankylosing spondylitis include back pain and stiffness. These problems often start in late adolescence or early adulthood. Over time, ankylosing spondylitis can fuse the vertebrae together, limiting movement. Symptoms can worsen, improve, or stop altogether. The disease has no cure, but medicines can relieve the pain, swelling and other symptoms. Exercise can also help.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing Spondylitis" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

Last Updated: 24 Nov 2009

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing Spondylitis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

http://www.kickas.org

Last Updated: 24 Nov 2009

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ankylosing Spondylitis" returned 1128 free, full-text research articles on human participants. First 3 results:

Long-lasting unspecific intestinal inflammation in ankylosing spondylitis evolving into Crohn's disease.
 

Author(s): Antonio Tursi, Cosimo Damiano Inchingolo

Journal: J Gastrointestin Liver Dis. 2013 Dec;22(4):472-3.

 

Last Updated: 26 Dec 2013

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Transcriptome network analysis reveals potential candidate genes for ankylosing spondylitis.
 

Author(s): Z-Q Zhu, J-S Tang, X-J Cao

Journal: Eur Rev Med Pharmacol Sci. 2013 Dec;17(23):3178-85.

 

Ankylosing spondylitis (AS) is a chronic, inflammatory arthritis and autoimmune disease.

Last Updated: 16 Dec 2013

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Allicin attenuates inflammation and suppresses HLA-B27 protein expression in ankylosing spondylitis mice.
 

Author(s): Xin Gu, Haishan Wu, Peiliang Fu

Journal: Biomed Res Int. 2013 ;2013():171573.

 

Here we aimed to determine the therapeutic effect of allicin on ankylosing spondylitis (AS) and explore the mechanism(s) of action. AS mouse model was constructed by transferring the HLA-B2704 gene into Kunming mice and verified by RT-PCR and CT imaging. Verified AS mice were randomly ...

Last Updated: 10 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ankylosing Spondylitis" returned 77 free, full-text review articles on human participants. First 3 results:

Ankylosing spondylitis: an update.
 

Author(s): Vera Golder, Lionel Schachna

Journal: Aust Fam Physician. 2013 Nov;42(11):780-4.

 

Ankylosing spondylitis (AS) affects one in 200 individuals and is usually diagnosed many years after onset of symptoms. Chronic back pain is common and recognition of early disease requires clinical experience and a high index of suspicion. Further, inflammatory markers are not invariably ...

Last Updated: 12 Nov 2013

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Variables related to work productivity loss in patients with ankylosing spondylitis.
 

Author(s): Renata Frauendorf, Marcelo de Medeiros Pinheiro, Rozana Mesquita Ciconelli

Journal: Rev Bras Reumatol. ;53(3):303-9.

 

The work productivity loss due to ankylosing spondylitis (AS) has become subject of interest because of its socioeconomic impact. In addition to physical limitations, other variables seem to affect the productivity of those patients, who often withdraw early from the labor force. ...

Last Updated: 20 Sep 2013

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The link between ankylosing spondylitis, Crohn's disease, Klebsiella, and starch consumption.
 

Author(s): Taha Rashid, Clyde Wilson, Alan Ebringer

Journal: Clin. Dev. Immunol.. 2013 ;2013():872632.

 

Both ankylosing spondylitis (AS) and Crohn's disease (CD) are chronic and potentially disabling interrelated conditions, which have been included under the group of spondyloarthropathies. The results of a large number of studies support the idea that an enteropathic pathogen, Klebsiella ...

Last Updated: 19 Jun 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

European Ankylosing Spondylitis Infliximab Cohort (EASIC) Follow up Registration Study
 

Status: Not yet recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 27 Jan 2011

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Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study
 

Status: Recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 12 Sep 2014

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