Ankylosing spondylitis

Common Name(s)

Ankylosing spondylitis, Marie Strumpell disease, AS, Bechterew disease

Ankylosing spondylitis (AS) is an inflammatory joint disease that primarily affects the spine. As ankylosing spondylitis progresses, the vertebrae in the spine fuse together (ankylosis), causing the spine to be less flexible and may result in a hunched-forward posture. Signs and symptoms of ankylosing spondylitis may include pain and stiffness in your lower back and hips. Affected areas can include the joints between the base of your spine and pelvis, the joints between the vertebrae, the hip joints, and the shoulder joints.

Up to 40 percent of individuals with ankylosing spondylitis will have eye inflammation that may cause eye pain, sensitivity to light and blurred vision. Other less common complications include restricted lung function and heart inflammation. Risk factors of ankylosing spondylitis include gender and age, as men develop ankylosing spondylitis more often than women and onset of symptoms typically occurs in late adolescence and early adulthood. The exact cause of ankylosing spondylitis is unknown, but it is believed that both genetic and environmental factors play a role. One genetic factor is the HLA-B gene, which provides instructions for making a protein that helps the immune system distinguish the body’s own proteins from foreign invaders (such as viruses and bacteria). Individuals who have the HLA-B27 variation of the HLA-B gene are at greater risk of developing ankylosing spondylitis.

Your doctor may use a physical exam along with imaging tests and lab tests to diagnosis the condition. There is no cure for ankylosing spondylitis, but there are treatment options that can help decrease your pain and reduce your symptoms. Support groups are good resources for additional information. Contact a doctor if you or someone in your family has been diagnosed with ankylosing spondylitis to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing spondylitis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

View Details
Logo
Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

Last Updated: 24 Nov 2009

View Details
stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing spondylitis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

View Details
Logo
Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

http://www.kickas.org

Last Updated: 24 Nov 2009

View Details
stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ankylosing spondylitis" returned 1378 free, full-text research articles on human participants. First 3 results:

Determining the relationship of kinesiophobia with respiratory functions and functional capacity in ankylosing spondylitis.
 

Author(s): Göktuğ Er, Ender AngIn

Journal: Medicine (Baltimore). 2017 Jul;96(29):e7486.

 

Ankylosing spondylitis (AS) is a common inflammatory rheumatic disease that affects the axial skeleton, causes inflammatory lower back pain, and structural and functional disorders, which affect quality of life negatively.The purpose of this study is to investigate the effects of ...

Last Updated: 20 Jul 2017

Go To URL
One-stage surgical treatment of cervical spine fracture-dislocation in patients with ankylosing spondylitis via the combined anterior-posterior approach.
 

Author(s): Axiang He, Dong Xie, Xiaomin Cai, Bo Qu, Qin Kong, Chenhui Xu, Lili Yang, Xiongsheng Chen, Lianshun Jia

Journal: Medicine (Baltimore). 2017 Jul;96(27):e7432.

 

The aim of the article is to investigate the efficacy and safety of 1-stage surgical therapy via combined anterior-posterior approach on cervical spine fracture in patients with ankylosing spondylitis (AS).We retrospectively analyzed profiles of 12 AS patients with severe fracture-dislocation ...

Last Updated: 6 Jul 2017

Go To URL
The genetic association between polymorphisms in lymphotoxin-α gene and ankylosing spondylitis susceptibility in Chinese group: A case-control study.
 

Author(s): Bei Jia, Xiangbei Qi

Journal: Medicine (Baltimore). 2017 May;96(19):e6796.

 

The study was designed to reveal the genetic relationship of lymphotoxin-α (LTA) polymorphisms with risk of ankylosing spondylitis (AS) in Chinese Han population.LTA polymorphisms were genotyped by polymerase chain reaction-direct sequencing (PCR-DS) in 138 AS patients and 141 healthy ...

Last Updated: 10 May 2017

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ankylosing spondylitis" returned 107 free, full-text review articles on human participants. First 3 results:

Safety of tumor necrosis factor-alpha inhibitors for treatment of ankylosing spondylitis: A meta-analysis.
 

Author(s): Zeren Ma, Xiaoping Liu, Xiaosheng Xu, Jie Jiang, Jian Zhou, Jia Wang, Dewang Chen, Song Luo

Journal: Medicine (Baltimore). 2017 Jun;96(25):e7145.

 

Ankylosing spondylitis (AS) is a chronic immune-mediated disease affecting the sacroiliac joints and the spine, manifesting with new bone formation and osteopenia. Five tumor necrosis factor-alpha (TNF-α) inhibitors (infliximab, etanercept, adalimumab, certolizumab, and golimumab) ...

Last Updated: 22 Jun 2017

Go To URL
Role of HLA-B27 in the pathogenesis of ankylosing spondylitis (Review).
 

Author(s): Bin Chen, Jia Li, Chongru He, Dahe Li, Wenwen Tong, Yuming Zou, Weidong Xu

Journal: Mol Med Rep. 2017 Apr;15(4):1943-1951.

 

The study of ankylosing spondylitis (AS) has made significant progress over the last decade. Genome-wide association studies have identified and further substantiated the role of susceptibility genes outside the major histocompatibility complex locus. However, human leukocyte antigen ...

Last Updated: 5 Mar 2017

Go To URL
Role of gut microbiome in ankylosing spondylitis: an analysis of studies in literature.
 

Author(s): Yong-Yue Xu, Xi Tan, Yi-Ting He, Ying-Yan Zhou, Xiao-Hong He, Run-Yue Huang

Journal: Discov Med. 2016 Dec;22(123):361-370.

 

Gut microbiome is considered to be involved in the pathogenesis of ankylosing spondylitis (AS). We conducted a comprehensive literature review in this area to facilitate future research.

Last Updated: 1 Feb 2017

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Physical Training Program in Ankylosing Spondylitis
 

Status: Recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 21 Feb 2017

Go to URL

Last Updated: 13 Jul 2017

Go to URL

Last Updated: 4 May 2017

Go to URL