Ankylosing spondylitis

Common Name(s)

Ankylosing spondylitis, AS, Bechterew disease, Marie Strumpell disease

Ankylosing spondylitis (AS) is an inflammatory joint disease that primarily affects the spine. As ankylosing spondylitis progresses, the vertebrae in the spine fuse together (ankylosis), causing the spine to be less flexible and may result in a hunched-forward posture. Signs and symptoms of ankylosing spondylitis may include pain and stiffness in your lower back and hips. Affected areas can include the joints between the base of your spine and pelvis, the joints between the vertebrae, the hip joints, and the shoulder joints.

Up to 40 percent of individuals with ankylosing spondylitis will have eye inflammation that may cause eye pain, sensitivity to light and blurred vision. Other less common complications include restricted lung function and heart inflammation. Risk factors of ankylosing spondylitis include gender and age, as men develop ankylosing spondylitis more often than women and onset of symptoms typically occurs in late adolescence and early adulthood. The exact cause of ankylosing spondylitis is unknown, but it is believed that both genetic and environmental factors play a role. One genetic factor is the HLA-B gene, which provides instructions for making a protein that helps the immune system distinguish the body’s own proteins from foreign invaders (such as viruses and bacteria). Individuals who have the HLA-B27 variation of the HLA-B gene are at greater risk of developing ankylosing spondylitis.

Your doctor may use a physical exam along with imaging tests and lab tests to diagnosis the condition. There is no cure for ankylosing spondylitis, but there are treatment options that can help decrease your pain and reduce your symptoms. Support groups are good resources for additional information. Contact a doctor if you or someone in your family has been diagnosed with ankylosing spondylitis to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing spondylitis" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

Last Updated: 24 Nov 2009

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing spondylitis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

http://www.kickas.org

Last Updated: 24 Nov 2009

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ankylosing spondylitis" returned 1459 free, full-text research articles on human participants. First 3 results:

A case of essential thrombocythemia and ankylosing spondylitis treated with a combination of anagrelide, disease-modifying antirheumatic drugs, and etanercept.
 

Author(s): Vanja Zeremski, Aleksandar Savić, Tatjana Ilić, Ivana Milosević, Marina Maksimović, Biljana Vucković

Journal: Srp Arh Celok Lek. ;144(1-2):81-4.

 

A high platelet count, or thrombocytosis, is either a reactive process or a result of a myeloproliferative disorder. Ankylosing spondylitis is a chronic inflammatory rheumatic disease affecting the spine and sometimes peripheral joints in which reactive mild to moderate thrombocytosis ...

Last Updated: 9 Jun 2016

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Comparison of Sagittal Spinopelvic Alignment in Patients With Ankylosing Spondylitis and Thoracolumbar Fracture.
 

Author(s): Tao Pan, Bang-Ping Qian, Yong Qiu

Journal: Medicine (Baltimore). 2016 Jan;95(4):e2585.

 

This article is a comparative study. The aim of the study is to investigate the difference of sagittal alignment of the pelvis and spine between patients with thoracolumbar kyphosis secondary to ankylosing spondylitis (AS) and thoracolumbar fracture, and to evaluate the role of sacropelvic ...

Last Updated: 30 Jan 2016

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Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis.
 

Author(s): Dominique Baeten, Joachim Sieper, Jürgen Braun, Xenofon Baraliakos, Maxime Dougados, Paul Emery, Atul Deodhar, Brian Porter, Ruvie Martin, Mats Andersson, Shephard Mpofu, Hanno B Richards, ,

Journal: N. Engl. J. Med.. 2015 Dec;373(26):2534-48.

 

Secukinumab is an anti-interleukin-17A monoclonal antibody that has been shown to control the symptoms of ankylosing spondylitis in a phase 2 trial. We conducted two phase 3 trials of secukinumab in patients with active ankylosing spondylitis.

Last Updated: 24 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ankylosing spondylitis" returned 109 free, full-text review articles on human participants. First 3 results:

Do Anti-TNF Blockers Increase the Risk of Lung Involvement in Patients with Ankylosing Spondylitis or Psoriatic Arthritis? A Systematic Review.
 

Author(s): Fabiola Atzeni, Elisabetta Grillo, Ignazio F Masala, Piercarlo Sarzi-Puttini, Gareth T Jones

Journal: Isr. Med. Assoc. J.. ;18(3-4):154-5.

 

Lung involvement is a well-recognized extra-articular manifestation of ankylosing spondylitis (AS). Anecdotal reports suggest that the use of anti-TNF drugs may be related to lung disease and pulmonary fibrosis. To examine the association between anti-TNF drugs and the development ...

Last Updated: 27 May 2016

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The Role of MicroRNAS in Ankylosing Spondylitis.
 

Author(s): Zheng Li, Sunny H Wong, Jianxiong Shen, Matthew T V Chan, William Ka Kei Wu

Journal: Medicine (Baltimore). 2016 Apr;95(14):e3325.

 

Ankylosing spondylitis (AS) is a common and genetically heterozygous inflammatory rheumatic disease characterized by new bone formation, ankylosis and inflammation of hip, sacroiliac joints and spine. Until now, there is no method for early diagnosis of AS and the effective treatment ...

Last Updated: 9 Apr 2016

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Comparative Effectiveness of Biologic Therapy Regimens for Ankylosing Spondylitis: A Systematic Review and a Network Meta-Analysis.
 

Author(s): Chao Chen, XiaoLin Zhang, Lu Xiao, XueSong Zhang, XinLong Ma

Journal: Medicine (Baltimore). 2016 Mar;95(11):e3060.

 

To establish the comparative effectiveness of all available biologic therapy regimens for ankylosing spondylitis, we performed a systematic review and a Bayesian network meta-analysis of randomized controlled trials. PubMed, Medline, Embase, Cochrane library, and ClinicalTrials.gov ...

Last Updated: 18 Mar 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

European Ankylosing Spondylitis Infliximab Cohort (EASIC) Follow up Registration Study
 

Status: Not yet recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 27 Jan 2011

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Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study
 

Status: Recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 23 Jul 2016

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