Ankylosing spondylitis

Common Name(s)

Ankylosing spondylitis, AS, Bechterew disease, Marie Strumpell disease

Ankylosing spondylitis (AS) is an inflammatory joint disease that primarily affects the spine. As ankylosing spondylitis progresses, the vertebrae in the spine fuse together (ankylosis), causing the spine to be less flexible and may result in a hunched-forward posture. Signs and symptoms of ankylosing spondylitis may include pain and stiffness in your lower back and hips. Affected areas can include the joints between the base of your spine and pelvis, the joints between the vertebrae, the hip joints, and the shoulder joints.

Up to 40 percent of individuals with ankylosing spondylitis will have eye inflammation that may cause eye pain, sensitivity to light and blurred vision. Other less common complications include restricted lung function and heart inflammation. Risk factors of ankylosing spondylitis include gender and age, as men develop ankylosing spondylitis more often than women and onset of symptoms typically occurs in late adolescence and early adulthood. The exact cause of ankylosing spondylitis is unknown, but it is believed that both genetic and environmental factors play a role. One genetic factor is the HLA-B gene, which provides instructions for making a protein that helps the immune system distinguish the body’s own proteins from foreign invaders (such as viruses and bacteria). Individuals who have the HLA-B27 variation of the HLA-B gene are at greater risk of developing ankylosing spondylitis.

Your doctor may use a physical exam along with imaging tests and lab tests to diagnosis the condition. There is no cure for ankylosing spondylitis, but there are treatment options that can help decrease your pain and reduce your symptoms. Support groups are good resources for additional information. Contact a doctor if you or someone in your family has been diagnosed with ankylosing spondylitis to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing spondylitis" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

Last Updated: 24 Nov 2009

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ankylosing spondylitis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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Kickas.org

KickAs.org strives to provide the means for ankylosing spondylitis sufferers worldwide to share with, and learn from, the experiences of others coping with ankylosing spondylitis and related conditions in a safe and supportive environment.

http://www.kickas.org

Last Updated: 24 Nov 2009

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ankylosing spondylitis" returned 1179 free, full-text research articles on human participants. First 3 results:

Ankylosing spondylitis associated with pulmonary arterial hypertension.
 

Author(s): Yao-Min Hung, Chin-Chang Cheng, Shue-Ren Wann, Shoa-Lin Lin

Journal: Intern. Med.. 2015 ;54(4):431-4.

 

Pulmonary arterial hypertension (PAH) is a frequent complication of connective tissue diseases, such as systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis. However, the occurrence of PAH in a patient with ankylosing spondylitis (AS) has not been previously reported ...

Last Updated: 9 Mar 2015

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Xinfeng capsule improves pulmonary function in ankylosing spondylitis patients via NF-ΚB-iNOS-NO signaling pathway.
 

Author(s): Jian Liu, Yajun Qi, Li Zheng, Yunxiang Cao, Lei Wan, Wenfang Ye, Li Fang

Journal: J Tradit Chin Med. 2014 Dec;34(6):657-65.

 

To study changes in the nuclear factor-κB p65 (NF-κB p65)-inducible nitric oxide synthase (iNOS)-nitric oxide (NO) signaling pathway and the effects of Xinfeng capsules (XFC) in patients with ankylosing spondylitis (AS).

Last Updated: 26 Jan 2015

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Fetuin-A is related to syndesmophytes in patients with ankylosing spondylitis: a case control study.
 

Author(s): Tugba Tuylu, Ismail Sari, Dilek Solmaz, Didem Leyla Kozaci, Servet Akar, Necati Gunay, Fatos Onen, Nurullah Akkoc

Journal: Clinics (Sao Paulo). 2014 Dec;69(10):688-93.

 

New bone formation is one of the hallmark characteristics of ankylosing spondylitis, which is thereby associated with syndesmophytes. Fetuin-A is a molecule that is abundantly found in calcified tissues and it shows high affinity for calcium phosphate minerals and related compounds. ...

Last Updated: 18 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ankylosing spondylitis" returned 82 free, full-text review articles on human participants. First 3 results:

[Genetics of ankylosing spondylitis].
 

Author(s): Patricia Castro-Santos, Miguel A Gutiérrez, Roberto Díaz-Peña

Journal: Rev Med Chil. 2014 Sep;142(9):1165-73.

 

Ankylosing spondylitis (AS) is a prototypical inflammatory disease of the locomotor system affecting axial skeleton. It is part of the general group of spondyloarthopathies (SpA). Its strong association with histocompatibility antigen HLA-B27 is known since 1973. However, HLA-B27 ...

Last Updated: 18 Dec 2014

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Comparative efficacy and safety of biosimilar infliximab and other biological treatments in ankylosing spondylitis: systematic literature review and meta-analysis.
 

Author(s): Petra Baji, Márta Péntek, Sándor Szántó, Pál Géher, László Gulácsi, Orsolya Balogh, Valentin Brodszky

Journal: Eur J Health Econ. 2014 May;15 Suppl 1():S45-52.

 

To compare the efficacy and safety of infliximab-biosimilar with other biological drugs for the treatment of active ankylosing spondylitis (AS).

Last Updated: 6 Jun 2014

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Adipokines, biomarkers of endothelial activation, and metabolic syndrome in patients with ankylosing spondylitis.
 

Author(s): Fernanda Genre, Raquel López-Mejías, José A Miranda-Filloy, Begoña Ubilla, Beatriz Carnero-López, Ricardo Blanco, Trinitario Pina, Carlos González-Juanatey, Javier Llorca, Miguel A González-Gay

Journal: Biomed Res Int. 2014 ;2014():860651.

 

Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease associated with accelerated atherosclerosis and increased risk of cardiovascular (CV) disease. AS patients also display a high prevalence of features clustered under the name of metabolic syndrome (MeS). Anti-TNF- ...

Last Updated: 23 Apr 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

European Ankylosing Spondylitis Infliximab Cohort (EASIC) Follow up Registration Study
 

Status: Not yet recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 27 Jan 2011

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Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study
 

Status: Recruiting

Condition Summary: Ankylosing Spondylitis

 

Last Updated: 3 Dec 2014

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