Amyotrophic Lateral Sclerosis

Common Name(s)

Amyotrophic Lateral Sclerosis, Amyotrophic Lateral Sclerosis (ALS), Lou Gehrig's disease

Amyotrophic lateral sclerosis (ALS), also referred to as "Lou Gehrig's disease" is a disease of the motor nerve cells in the brain and spinal cord. ALS is caused by progressive loss of motor nerves in these areas and affects approximately 1 out of 100,000 people. The diagnosis of ALS is usually based on clinical features, electrodiagnostic testing (EMG), and exclusion of other health conditions with related symptoms.  Most people with amyotrophic lateral sclerosis have a form of the condition that is described as sporadic or noninherited. The cause of sporadic amyotrophic lateral sclerosis is largely unknown but probably involves a combination of genetic and environmental factors. About 10 percent of people with amyotrophic lateral sclerosis have a familial form of the condition, which is caused by an inherited genetic mutation.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Amyotrophic Lateral Sclerosis" for support, advocacy or research.

ALS Association

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig’s Disease and their families to live fuller lives by providing them with compassionate care and support.

Last Updated: 2 May 2014

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Irish Motor Neurone Disease Assoication

To encourage and promote the best methods of care, education, research and treatment for people with Motor Neurone Disease throughout the State of Ireland, contributing to worldwide efforts in research and development of treatment. To establish and promote models of good practice in the delivery of specialised services to our patients, their families and carers, setting standards of excellence. To communicate widely knowledge of Motor Neurone Disease and related disorders in order to raise awareness in the wider community.

Last Updated: 7 Jul 2015

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Les Turner ALS Foundation

To support medical research into the cause, treatment and cure of ALS; clinical and support services for patients and families living; and dissemination of information about ALS.

Last Updated: 31 Dec 2012

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 15 Jul 2015

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

Last Updated: 20 Dec 2012

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Scottish Motor Neurone Disease Association

We want to make Scotland a place where those living with motor neurone disease/amyotrophic lateral sclerosis can expect consistent, high standards of care and where we work directly towards a cure.

Last Updated: 7 Jul 2015

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The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

Last Updated: 12 Jun 2013

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Amyotrophic Lateral Sclerosis" for support, advocacy or research.

ALS Association

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig’s Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa.org/

Last Updated: 2 May 2014

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Irish Motor Neurone Disease Assoication

To encourage and promote the best methods of care, education, research and treatment for people with Motor Neurone Disease throughout the State of Ireland, contributing to worldwide efforts in research and development of treatment. To establish and promote models of good practice in the delivery of specialised services to our patients, their families and carers, setting standards of excellence. To communicate widely knowledge of Motor Neurone Disease and related disorders in order to raise awareness in the wider community.

http://www.imnda.ie

Last Updated: 7 Jul 2015

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Les Turner ALS Foundation

To support medical research into the cause, treatment and cure of ALS; clinical and support services for patients and families living; and dissemination of information about ALS.

http://www.lesturnerals.org

Last Updated: 31 Dec 2012

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 15 Jul 2015

View Details
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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

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Scottish Motor Neurone Disease Association

We want to make Scotland a place where those living with motor neurone disease/amyotrophic lateral sclerosis can expect consistent, high standards of care and where we work directly towards a cure.

http://www.scotmnd.org.uk

Last Updated: 7 Jul 2015

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The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa-ec.org

Last Updated: 12 Jun 2013

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

http://www.unitedspinal.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Amyotrophic Lateral Sclerosis" returned 1412 free, full-text research articles on human participants. First 3 results:

Military service, deployments, and exposures in relation to amyotrophic lateral sclerosis survival.
 

Author(s): John D Beard, Lawrence S Engel, David B Richardson, Marilie D Gammon, Coleen Baird, David M Umbach, Kelli D Allen, Catherine L Stanwyck, Jean Keller, Dale P Sandler, Silke Schmidt, Freya Kamel

Journal:

 

Military veterans may have higher rates of amyotrophic lateral sclerosis (ALS) mortality than non-veterans. Few studies, with sparse exposure information and mixed results, have studied relationships between military-related factors and ALS survival. We evaluated associations between ...

Last Updated: 10 Oct 2017

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Application of different ventilator modes in patients with amyotrophic lateral sclerosis according to certain clinical situations: A Case Report.
 

Author(s): Donghwi Park

Journal: Medicine (Baltimore). 2017 Aug;96(34):e7899.

 

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease that involves limb, axial, bulbar, and respiratory muscles. Fatigue and weakness of the respiratory muscles eventually induce respiratory insufficiency, which is one of the main causes of death ...

Last Updated: 23 Aug 2017

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TBK1 mutations in Italian patients with amyotrophic lateral sclerosis: genetic and functional characterisation.
 

Author(s): Laura Pozzi, Fabiola Valenza, Lorena Mosca, Andrea Dal Mas, Teuta Domi, Alessandro Romano, Claudia Tarlarini, Yuri Matteo Falzone, Lucio Tremolizzo, Gianni Sorarù, Federica Cerri, Pilar M Ferraro, Silvia Basaia, Federica Agosta, Raffaella Fazio, Mauro Comola, Giancarlo Comi, Maurizio Ferrari, Angelo Quattrini, Christian Lunetta, Silvana Penco, Dario Bonanomi, Paola Carrera, Nilo Riva

Journal: J. Neurol. Neurosurg. Psychiatr.. 2017 Oct;88(10):869-875.

 

TANK-binding kinase 1 (TBK1) gene has been recently identified as a causative gene of amyotrophic lateral sclerosis (ALS).

Last Updated: 20 Aug 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Amyotrophic Lateral Sclerosis" returned 233 free, full-text review articles on human participants. First 3 results:

The changing picture of amyotrophic lateral sclerosis: lessons from European registers.
 

Author(s): Orla Hardiman, Ammar Al-Chalabi, Carol Brayne, Ettore Beghi, Leonard H van den Berg, Adriano Chio, Sarah Martin, Giancarlo Logroscino, James Rooney

Journal: J. Neurol. Neurosurg. Psychiatr.. 2017 Jul;88(7):557-563.

 

Prospective population based-registers of amyotrophic lateral sclerosis (ALS) have operated in Europe for over two decades, and have provided important insights into our understanding of ALS. Here, we review the benefits that population registers have brought to the understanding ...

Last Updated: 12 Mar 2017

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Neuron-Microglia Interactions in Motor Neuron Degeneration. The Inflammatory Hypothesis in Amyotrophic Lateral Sclerosis Revisited.
 

Author(s): Manuel J Rodríguez, Nicole Mahy

Journal: Curr. Med. Chem.. 2016 ;23(42):4753-4772.

 

Research onto the pathogenesis of amyotrophic lateral sclerosis (ALS) has obtained notable gene discoveries, although, to date, only progress with regard to treatment has been very modest. Currently ALS is considered a multifactorial disease that presents diverse clinical presentations, ...

Last Updated: 24 Nov 2016

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Application of botulinum toxin to treat sialorrhea in amyotrophic lateral sclerosis patients: a literature review.
 

Author(s): Ademar Francisco de Oliveira, Gêssyca Adryene de Menezes Silva, Débora Milenna Xavier Almeida

Journal: Einstein (Sao Paulo). ;14(3):431-434.

 

Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease characterized by the degeneration of motor neurons, which are the central nervous system cells that control voluntary muscle movements. The excessive salivation (sialorrhea) is present in approximately ...

Last Updated: 19 Oct 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Trial of Amivita in Amyotrophic Lateral Sclerosis
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis

 

Last Updated: 24 Apr 2017

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The National Amyotrophic Lateral Sclerosis Registry
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis

 

Last Updated: 8 Aug 2016

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Amyotrophic Lateral Sclerosis: a New Paradigm
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis

 

Last Updated: 2 Mar 2017

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