Amyotrophic Lateral Sclerosis

Common Name(s)

Amyotrophic Lateral Sclerosis, Amyotrophic Lateral Sclerosis (ALS), Lou Gehrig's disease

Amyotrophic lateral sclerosis (ALS), also referred to as "Lou Gehrig's disease" is a disease of the motor nerve cells in the brain and spinal cord. ALS is caused by progressive loss of motor nerves in these areas and affects approximately 1 out of 100,000 people. The diagnosis of ALS is usually based on clinical features, electrodiagnostic testing (EMG), and exclusion of other health conditions with related symptoms.  Most people with amyotrophic lateral sclerosis have a form of the condition that is described as sporadic or noninherited. The cause of sporadic amyotrophic lateral sclerosis is largely unknown but probably involves a combination of genetic and environmental factors. About 10 percent of people with amyotrophic lateral sclerosis have a familial form of the condition, which is caused by an inherited genetic mutation.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Amyotrophic Lateral Sclerosis" for support, advocacy or research.

ALS Association

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig’s Disease and their families to live fuller lives by providing them with compassionate care and support.

Last Updated: 2 May 2014

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Irish Motor Neurone Disease Assoication

To encourage and promote the best methods of care, education, research and treatment for people with Motor Neurone Disease throughout the State of Ireland, contributing to worldwide efforts in research and development of treatment. To establish and promote models of good practice in the delivery of specialised services to our patients, their families and carers, setting standards of excellence. To communicate widely knowledge of Motor Neurone Disease and related disorders in order to raise awareness in the wider community.

Last Updated: 7 Jul 2015

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Les Turner ALS Foundation

To support medical research into the cause, treatment and cure of ALS; clinical and support services for patients and families living; and dissemination of information about ALS.

Last Updated: 31 Dec 2012

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 15 Jul 2015

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

Last Updated: 20 Dec 2012

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Scottish Motor Neurone Disease Association

We want to make Scotland a place where those living with motor neurone disease/amyotrophic lateral sclerosis can expect consistent, high standards of care and where we work directly towards a cure.

Last Updated: 7 Jul 2015

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The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

Last Updated: 12 Jun 2013

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Amyotrophic Lateral Sclerosis" for support, advocacy or research.

ALS Association

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig’s Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa.org/

Last Updated: 2 May 2014

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Irish Motor Neurone Disease Assoication

To encourage and promote the best methods of care, education, research and treatment for people with Motor Neurone Disease throughout the State of Ireland, contributing to worldwide efforts in research and development of treatment. To establish and promote models of good practice in the delivery of specialised services to our patients, their families and carers, setting standards of excellence. To communicate widely knowledge of Motor Neurone Disease and related disorders in order to raise awareness in the wider community.

http://www.imnda.ie

Last Updated: 7 Jul 2015

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Les Turner ALS Foundation

To support medical research into the cause, treatment and cure of ALS; clinical and support services for patients and families living; and dissemination of information about ALS.

http://www.lesturnerals.org

Last Updated: 31 Dec 2012

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 15 Jul 2015

View Details
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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

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Scottish Motor Neurone Disease Association

We want to make Scotland a place where those living with motor neurone disease/amyotrophic lateral sclerosis can expect consistent, high standards of care and where we work directly towards a cure.

http://www.scotmnd.org.uk

Last Updated: 7 Jul 2015

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The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa-ec.org

Last Updated: 12 Jun 2013

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

http://www.unitedspinal.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Amyotrophic Lateral Sclerosis" returned 1366 free, full-text research articles on human participants. First 3 results:

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.
 

Author(s): Kelly L Williams, Simon Topp, Shu Yang, Bradley Smith, Jennifer A Fifita, Sadaf T Warraich, Katharine Y Zhang, Natalie Farrawell, Caroline Vance, Xun Hu, Alessandra Chesi, Claire S Leblond, Albert Lee, Stephanie L Rayner, Vinod Sundaramoorthy, Carol Dobson-Stone, Mark P Molloy, Marka van Blitterswijk, Dennis W Dickson, Ronald C Petersen, Neill R Graff-Radford, Bradley F Boeve, Melissa E Murray, Cyril Pottier, Emily Don, Claire Winnick, Emily P McCann, Alison Hogan, Hussein Daoud, Annie Levert, Patrick A Dion, Jun Mitsui, Hiroyuki Ishiura, Yuji Takahashi, Jun Goto, Jason Kost, Cinzia Gellera, Athina Soragia Gkazi, Jack Miller, Joanne Stockton, William S Brooks, Karyn Boundy, Meraida Polak, José Luis Muñoz-Blanco, Jesús Esteban-Pérez, Alberto Rábano, Orla Hardiman, Karen E Morrison, Nicola Ticozzi, Vincenzo Silani, Jacqueline de Belleroche, Jonathan D Glass, John B J Kwok, Gilles J Guillemin, Roger S Chung, Shoji Tsuji, Robert H Brown, Alberto García-Redondo, Rosa Rademakers, John E Landers, Aaron D Gitler, Guy A Rouleau, Nicholas J Cole, Justin J Yerbury, Julie D Atkin, Christopher E Shaw, Garth A Nicholson, Ian P Blair

Journal:

 

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping, fatal neurodegenerative disorders in which the molecular and pathogenic basis remains poorly understood. Ubiquitinated protein aggregates, of which TDP-43 is a major component, are a characteristic ...

Last Updated: 15 Apr 2016

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Dihuang Yinzi, a Classical Chinese Herbal Prescription, for Amyotrophic Lateral Sclerosis: A 12-Year Follow-up Case Report.
 

Author(s): Hui Qiu, Ji-Huang Li, Su-Bing Yin, Jiang-Qiong Ke, Chang-Lin Qiu, Guo-Qing Zheng

Journal: Medicine (Baltimore). 2016 Apr;95(14):e3324.

 

Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease with no effective treatment and death within 2 to 5 years after symptom onset. Here, we reported a case of ALS patient using modified Dihuang Yinzi (DHYZ), a classical traditional Chinese medicine ...

Last Updated: 9 Apr 2016

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Juvenile-onset Sporadic Amyotrophic Lateral Sclerosis with a Frameshift FUS Gene Mutation Presenting Unique Neuroradiological Findings and Cognitive Impairment.
 

Author(s): Kimitoshi Hirayanagi, Masayuki Sato, Natsumi Furuta, Kouki Makioka, Yoshio Ikeda

Journal: Intern. Med.. 2016 ;55(6):689-93.

 

A 24-year-old Japanese woman developed anterocollis, weakness of the proximal arms, and subsequent cognitive impairment. A neurological examination revealed amyotrophic lateral sclerosis (ALS) without a family history. Systemic muscle atrophy progressed rapidly. Cerebral MRI clearly ...

Last Updated: 17 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Amyotrophic Lateral Sclerosis" returned 209 free, full-text review articles on human participants. First 3 results:

Environmental Risk Factors and Amyotrophic Lateral Sclerosis: An Umbrella Review and Critical Assessment of Current Evidence from Systematic Reviews and Meta-Analyses of Observational Studies.
 

Author(s): Lazaros Belbasis, Vanesa Bellou, Evangelos Evangelou

Journal: Neuroepidemiology. 2016 ;46(2):96-105.

 

The pathogenesis of amyotrophic lateral sclerosis (ALS) involves both environmental and genetic factors. Our study aimed at summarising the environmental risk factors for ALS, assessing the evidence for diverse biases, and pinpointing risk factors with high epidemiological credibility.

Last Updated: 4 Feb 2016

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Complementary and Alternative Therapies in Amyotrophic Lateral Sclerosis.
 

Author(s): Richard S Bedlack, Nanette Joyce, Gregory T Carter, Sabrina Paganoni, Chafic Karam

Journal: Neurol Clin. 2015 Nov;33(4):909-36.

 

Given the severity of their illness and lack of effective disease-modifying agents, it is not surprising that most patients with amyotrophic lateral sclerosis (ALS) consider trying complementary and alternative therapies. Some of the most commonly considered alternative therapies ...

Last Updated: 30 Oct 2015

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Symptom Management and End-of-Life Care in Amyotrophic Lateral Sclerosis.
 

Author(s): Carlayne E Jackson, April L McVey, Stacy Rudnicki, Mazen M Dimachkie, Richard J Barohn

Journal: Neurol Clin. 2015 Nov;33(4):889-908.

 

The number of available symptomatic treatments has markedly enhanced the care of patients with amyotrophic lateral sclerosis (ALS). Once thought to be untreatable, patients with ALS today clearly benefit from multidisciplinary care. The impact of such care on the disease course, including ...

Last Updated: 30 Oct 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The National Amyotrophic Lateral Sclerosis Registry
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis

 

Last Updated: 8 Aug 2016

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Muscular Biomarkers in Amyotrophic Lateral Sclerosis
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis

 

Last Updated: 14 Oct 2016

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Bioenergetics and Protein Metabolism in Sporadic Amyotrophic Lateral Sclerosis
 

Status: Not yet recruiting

Condition Summary: Sporadic Amyotrophic Lateral Sclerosis

 

Last Updated: 22 Nov 2016

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