Amyotrophic Lateral Sclerosis

Common Name(s)

Amyotrophic Lateral Sclerosis, Amyotrophic Lateral Sclerosis (ALS), Lou Gehrig's disease

Amyotrophic lateral sclerosis (ALS), also referred to as "Lou Gehrig's disease" is a disease of the motor nerve cells in the brain and spinal cord. ALS is caused by progressive loss of motor nerves in these areas and affects approximately 1 out of 100,000 people. The diagnosis of ALS is usually based on clinical features, electrodiagnostic testing (EMG), and exclusion of other health conditions with related symptoms.  Most people with amyotrophic lateral sclerosis have a form of the condition that is described as sporadic or noninherited. The cause of sporadic amyotrophic lateral sclerosis is largely unknown but probably involves a combination of genetic and environmental factors. About 10 percent of people with amyotrophic lateral sclerosis have a familial form of the condition, which is caused by an inherited genetic mutation.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Amyotrophic Lateral Sclerosis" for support, advocacy or research.

ALS Association

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig’s Disease and their families to live fuller lives by providing them with compassionate care and support.

Last Updated: 2 May 2014

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Irish Motor Neurone Disease Assoication

To encourage and promote the best methods of care, education, research and treatment for people with Motor Neurone Disease throughout the State of Ireland, contributing to worldwide efforts in research and development of treatment. To establish and promote models of good practice in the delivery of specialised services to our patients, their families and carers, setting standards of excellence. To communicate widely knowledge of Motor Neurone Disease and related disorders in order to raise awareness in the wider community.

Last Updated: 7 Jul 2015

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Les Turner ALS Foundation

To support medical research into the cause, treatment and cure of ALS; clinical and support services for patients and families living; and dissemination of information about ALS.

Last Updated: 31 Dec 2012

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 15 Jul 2015

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

Last Updated: 20 Dec 2012

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Scottish Motor Neurone Disease Association

We want to make Scotland a place where those living with motor neurone disease/amyotrophic lateral sclerosis can expect consistent, high standards of care and where we work directly towards a cure.

Last Updated: 7 Jul 2015

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The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

Last Updated: 12 Jun 2013

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Amyotrophic Lateral Sclerosis" for support, advocacy or research.

ALS Association

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig’s Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa.org/

Last Updated: 2 May 2014

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Irish Motor Neurone Disease Assoication

To encourage and promote the best methods of care, education, research and treatment for people with Motor Neurone Disease throughout the State of Ireland, contributing to worldwide efforts in research and development of treatment. To establish and promote models of good practice in the delivery of specialised services to our patients, their families and carers, setting standards of excellence. To communicate widely knowledge of Motor Neurone Disease and related disorders in order to raise awareness in the wider community.

http://www.imnda.ie

Last Updated: 7 Jul 2015

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Les Turner ALS Foundation

To support medical research into the cause, treatment and cure of ALS; clinical and support services for patients and families living; and dissemination of information about ALS.

http://www.lesturnerals.org

Last Updated: 31 Dec 2012

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 15 Jul 2015

View Details
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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

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Scottish Motor Neurone Disease Association

We want to make Scotland a place where those living with motor neurone disease/amyotrophic lateral sclerosis can expect consistent, high standards of care and where we work directly towards a cure.

http://www.scotmnd.org.uk

Last Updated: 7 Jul 2015

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The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa-ec.org

Last Updated: 12 Jun 2013

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

http://www.unitedspinal.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Amyotrophic Lateral Sclerosis" returned 1337 free, full-text research articles on human participants. First 3 results:

Ophthalmic Manifestations of Amyotrophic Lateral Sclerosis (An American Ophthalmological Society Thesis).
 

Author(s): Nicholas J Volpe, Joseph Simonett, Amani A Fawzi, Teepu Siddique

Journal: Trans Am Ophthalmol Soc. 2015 ;113():T12-1-15.

 

To determine if clinical and histopathologic findings were present in the eyes of patients with amyotrophic lateral sclerosis (ALS) and explore correlations to an animal model of ALS.

Last Updated: 15 Feb 2016

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Automobile or Other Conveyance and Adaptive Equipment Certificate of Eligibility for Veterans or Members of the Armed Forces With Amyotrophic Lateral Sclerosis Connected to Military Service. Final rule.
 

Author(s):

Journal: Fed Regist. 2016 Jan;81(8):1512-3.

 

The Department of Veterans Affairs (VA) published an Interim Final Rule on February 25, 2015, to amend its adjudication regulations to provide a certificate of eligibility for financial assistance in the purchase of an automobile or other conveyance and adaptive equipment for all ...

Last Updated: 13 Jan 2016

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Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis.
 

Author(s): Elizabeth A Proctor, Lanette Fee, Yazhong Tao, Rachel L Redler, James M Fay, Yuliang Zhang, Zhengjian Lv, Ian P Mercer, Mohanish Deshmukh, Yuri L Lyubchenko, Nikolay V Dokholyan

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2016 Jan;113(3):614-9.

 

Since the linking of mutations in the Cu,Zn superoxide dismutase gene (sod1) to amyotrophic lateral sclerosis (ALS) in 1993, researchers have sought the connection between SOD1 and motor neuron death. Disease-linked mutations tend to destabilize the native dimeric structure of SOD1, ...

Last Updated: 20 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Amyotrophic Lateral Sclerosis" returned 197 free, full-text review articles on human participants. First 3 results:

Clinical and genetic basis of familial amyotrophic lateral sclerosis.
 

Author(s): Paulo Victor Sgobbi de Souza, Wladimir Bocca Vieira de Rezende Pinto, Marco Antônio Troccoli Chieia, Acary Souza Bulle Oliveira

Journal: Arq Neuropsiquiatr. 2015 Dec;73(12):1026-37.

 

Amyotrophic lateral sclerosis represents the most common neurodegenerative disease leading to upper and lower motor neuron compromise. Although the vast majority of cases are sporadic, substantial gain has been observed in the knowledge of the genetic forms of the disease, especially ...

Last Updated: 17 Dec 2015

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An Overview of Potential Targets for Treating Amyotrophic Lateral Sclerosis and Huntington's Disease.
 

Author(s): Caroline Zocatelli de Paula, Bruno Daniel Correia Gonçalves, Luciene Bruno Vieira

Journal: Biomed Res Int. 2015 ;2015():198612.

 

Neurodegenerative diseases affect millions of people worldwide. Progressive damage or loss of neurons, neurodegeneration, has severe consequences on the mental and physical health of a patient. Despite all efforts by scientific community, there is currently no cure or manner to slow ...

Last Updated: 21 Aug 2015

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Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis?
 

Author(s): Ahmed Abdelhak, Andreas Junker, Johannes Brettschneider, Jan Kassubek, Albert C Ludolph, Markus Otto, Hayrettin Tumani

Journal:

 

Many neurodegenerative disorders share a common pathophysiological pathway involving axonal degeneration despite different etiological triggers. Analysis of cytoskeletal markers such as neurofilaments, protein tau and tubulin in cerebrospinal fluid (CSF) may be a useful approach to ...

Last Updated: 12 Aug 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The National Amyotrophic Lateral Sclerosis Registry
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis

 

Last Updated: 28 Jul 2015

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Muscular Biomarkers in Amyotrophic Lateral Sclerosis
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis

 

Last Updated: 17 Jun 2016

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Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis; Chronic Respiratory Failure

 

Last Updated: 26 Mar 2010

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