Amyotrophic Lateral Sclerosis

Common Name(s)

Amyotrophic Lateral Sclerosis, Amyotrophic lateral sclerosis type 1, Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic lateral sclerosis (ALS), also referred to as "Lou Gehrig's disease" is a disease of the motor nerve cells in the brain and spinal cord. ALS is caused by progressive loss of motor nerves in these areas and affects approximately 1 out of 100,000 people. The diagnosis of ALS is usually based on clinical features, electrodiagnostic testing (EMG), and exclusion of other health conditions with related symptoms.  Most people with amyotrophic lateral sclerosis have a form of the condition that is described as sporadic or noninherited. The cause of sporadic amyotrophic lateral sclerosis is largely unknown but probably involves a combination of genetic and environmental factors. About 10 percent of people with amyotrophic lateral sclerosis have a familial form of the condition, which is caused by an inherited genetic mutation.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Amyotrophic Lateral Sclerosis" for support, advocacy or research.

ALS Association

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig’s Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa.org/

Last Updated: 22 Mar 2013

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Irish Motor Neurone Disease Assoication

To encourage and promote the best methods of care, education, research and treatment for people with Motor Neurone Disease throughout the State of Ireland, contributing to worldwide efforts in research and development of treatment. To establish and promote models of good practice in the delivery of specialised services to our patients, their families and carers, setting standards of excellence. To communicate widely knowledge of Motor Neurone Disease and related disorders in order to raise awareness in the wider community.

http://www.imnda.ie

Last Updated: 8 Oct 2013

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Les Turner ALS Foundation

To support medical research into the cause, treatment and cure of ALS; clinical and support services for patients and families living; and dissemination of information about ALS.

http://www.lesturnerals.org

Last Updated: 31 Dec 2012

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 8 Mar 2010

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

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Scottish Motor Neurone Disease Association

We want to make Scotland a place where those living with motor neurone disease/amyotrophic lateral sclerosis can expect consistent, high standards of care and where we work directly towards a cure.

http://www.scotmnd.org.uk

Last Updated: 24 Nov 2009

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The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa-ec.org

Last Updated: 12 Jun 2013

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

http://www.unitedspinal.org

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Amyotrophic Lateral Sclerosis" for support, advocacy or research.

ALS Association

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig’s Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa.org/

Last Updated: 22 Mar 2013

View Details
Irish Motor Neurone Disease Assoication

To encourage and promote the best methods of care, education, research and treatment for people with Motor Neurone Disease throughout the State of Ireland, contributing to worldwide efforts in research and development of treatment. To establish and promote models of good practice in the delivery of specialised services to our patients, their families and carers, setting standards of excellence. To communicate widely knowledge of Motor Neurone Disease and related disorders in order to raise awareness in the wider community.

http://www.imnda.ie

Last Updated: 8 Oct 2013

View Details
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Les Turner ALS Foundation

To support medical research into the cause, treatment and cure of ALS; clinical and support services for patients and families living; and dissemination of information about ALS.

http://www.lesturnerals.org

Last Updated: 31 Dec 2012

View Details
Logo
Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 8 Mar 2010

View Details
Logo
National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

View Details
Logo
Scottish Motor Neurone Disease Association

We want to make Scotland a place where those living with motor neurone disease/amyotrophic lateral sclerosis can expect consistent, high standards of care and where we work directly towards a cure.

http://www.scotmnd.org.uk

Last Updated: 24 Nov 2009

View Details
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The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa-ec.org

Last Updated: 12 Jun 2013

View Details
United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

http://www.unitedspinal.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Amyotrophic Lateral Sclerosis" returned 865 free, full-text research articles on human participants. First 3 results:

Progressive hemiparesis (Mills syndrome) with aphasia in amyotrophic lateral sclerosis.
 

Author(s): Dirk Bäumer, Richard Butterworth, Ricarda A L Menke, Kevin Talbot, Monika Hofer, Martin R Turner

Journal: Neurology. 2014 Feb;82(5):457-8.

 

The onset of motor symptoms in amyotrophic lateral sclerosis (ALS) is strikingly focal. In three-quarters of cases, weakness emerges unilaterally in one limb, typically spreading contiguously over months to become bilateral.(1) An extremely rare clinical syndrome of upper motor neuron-predominant, ...

Last Updated: 4 Feb 2014

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[Therapeutic concepts in Amyotrophic Lateral Sclerosis (ALS)].
 

Author(s): A C Ludolph

Journal: Drug Res (Stuttg). 2013 Nov;63 Suppl 1():S21.

 

Last Updated: 18 Nov 2013

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Depression, pain and quality of life in patients with amyotrophic lateral sclerosis: a cross-sectional study.
 

Author(s): A Pizzimenti, M Aragona, E Onesti, M Inghilleri

Journal: Funct. Neurol.. ;28(2):115-9.

 

The complications related to amyotrophic lateral sclerosis (ALS) include pain. A higher risk of depression and a negative effect on quality of life (QoL) might be expected in ALS patients with pain. The aims of this study were to evaluate the prevalence of pain in ALS patients, to ...

Last Updated: 18 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Amyotrophic Lateral Sclerosis" returned 97 free, full-text review articles on human participants. First 3 results:

[Genetic coherence between hereditary amyotrophic lateral sclerosis and frontotemporal dementia].
 

Author(s): Kristian Varden Gjerde, Ole-Bjørn Tysnes

Journal: Tidsskr. Nor. Laegeforen.. 2014 Feb;134(3):302-6.

 

Amyotrophic lateral sclerosis (ALS) has traditionally been considered purely as a motor condition with a progressive loss of upper and lower motor neurons, and without cognitive or behavioural impairment. In 2011 a new genetic mutation that may cause both ALS and frontotemporal dementia ...

Last Updated: 12 Feb 2014

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Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis.
 

Author(s): Federica Rizzo, Giulietta Riboldi, Sabrina Salani, Monica Nizzardo, Chiara Simone, Stefania Corti, Eva Hedlund

Journal: Cell. Mol. Life Sci.. 2014 Mar;71(6):999-1015.

 

Neurodegenerative disorders are characterized by the selective vulnerability and progressive loss of discrete neuronal populations. Non-neuronal cells appear to significantly contribute to neuronal loss in diseases such as amyotrophic lateral sclerosis (ALS), Parkinson, and Alzheimer's ...

Last Updated: 19 Feb 2014

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Is tracheostomy still an option in amyotrophic lateral sclerosis? Reflections of a multidisciplinary work group.
 

Author(s): Anne-Chantal Heritier Barras, Dan Adler, Ruxandra Iancu Ferfoglia, Bara Ricou, Yvan Gasche, Igor Leuchter, Samia Hurst, Monica Escher, Pierre Pollak, Jean-Paul Janssens,

Journal:

 

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with a poor prognosis. Survival and quality of life of ALS patients have improved through the implementation of multidisciplinary approaches, the use of percutaneous gastrostomy and of noninvasive (NIV) ...

Last Updated: 8 Aug 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis 1; Acquired Amyotrophic Lateral Sclerosis; Amyotrophic Lateral Sclerosis

 

Last Updated: 1 Nov 2013

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Genetics of ALS: Identification of Genes With Roles in Familial and Sporadic Amyotrophic Lateral Sclerosis (ALS) and Amyotrophic Lateral Sclerosis (ALS) With Frontotemporal Dementia
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis; Familial Amyotrophic Lateral Sclerosis; Amyotrophic Lateral Sclerosis With Frontotemporal Dementia; Lou Gehrig's Disease; Motor Neuron Disease; Primary Lateral Sclerosis

 

Last Updated: 1 Apr 2014

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The National Amyotrophic Lateral Sclerosis Registry
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis

 

Last Updated: 30 Oct 2013

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