Alzheimer Disease

Common Name(s)

Alzheimer Disease

Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. Alzheimer disease currently affects about 5 million people. About 75 percent of Alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. Although the cause of these cases is unknown, genetic changes are likely to play a role. Virtually all sporadic Alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older. The remaining cases of Alzheimer disease are familial, which means they are found in multiple members of a family. Familial Alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alzheimer Disease" for support, advocacy or research.

Alzheimer's Association

The mission of the Alzheimer's Association is to eliminate Alzheimer's disease through the advancement of research; to provide and enhance care and support for all affected; and to reduce the risk of dementia through the promotion of brain health.

Last Updated: 11 Feb 2013

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Alzheimer's Foundation of America

To provide optimal care and services to individuals confronting dementia, and to their caregivers and families--through member organizations dedicated to improving quality of life.

Last Updated: 9 Apr 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 3 Oct 2013

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

Last Updated: 20 Dec 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alzheimer Disease" for support, advocacy or research.

Alzheimer's Association

The mission of the Alzheimer's Association is to eliminate Alzheimer's disease through the advancement of research; to provide and enhance care and support for all affected; and to reduce the risk of dementia through the promotion of brain health.

http://www.alz.org

Last Updated: 11 Feb 2013

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Alzheimer's Foundation of America

To provide optimal care and services to individuals confronting dementia, and to their caregivers and families--through member organizations dedicated to improving quality of life.

http://www.alzfdn.org

Last Updated: 9 Apr 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 3 Oct 2013

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

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General Support Organizations

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General Resources

Alzheimer's Association Helpline

The Alzheimer's Association 24/7 Helpline provides reliable information and support to all those who need assistance. Call us toll-free anytime day or night at 800.272.3900. Our 24/7 Helpline serves people with memory loss, caregivers, health care professionals and the public.

Updated 15 Oct 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Alzheimer Disease" returned 1073 free, full-text research articles on human participants. First 3 results:

Effect of Xixin decoction on phosphorylation toxicity at specific sites of tau protein in brains of rats with sporadic Alzheimer disease.
 

Author(s): Yongchang Diwu, Jinzhou Tian, Jing Shi

Journal: J Tradit Chin Med. 2013 Dec;33(6):787-93.

 

To explore the mechanism of action of Xixin decoction (XXD) for the prevention and treatment of sporadic Alzheimer disease (SAD) by investigating the effects of XXD on the phosphorylation of Thr231 and Ser422 sites of tau protein.

Last Updated: 25 Mar 2014

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Mild cognitive impairment and asymptomatic Alzheimer disease subjects: equivalent β-amyloid and tau loads with divergent cognitive outcomes.
 

Author(s): Diego Iacono, Susan M Resnick, Richard O'Brien, Alan B Zonderman, Yang An, Olga Pletnikova, Gay Rudow, Barbara Crain, Juan C Troncoso

Journal: J. Neuropathol. Exp. Neurol.. 2014 Apr;73(4):295-304.

 

Older adults with intact cognition before death and substantial Alzheimer disease (AD) lesions at autopsy have been termed "asymptomatic AD subjects" (ASYMAD). We previously reported hypertrophy of neuronal cell bodies, nuclei, and nucleoli in the CA1 of the hippocampus (CA1), anterior ...

Last Updated: 25 Mar 2014

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The growth and impact of Alzheimer disease centers as measured by social network analysis.
 

Author(s): Michael E Hughes, John Peeler, John B Hogenesch, John Q Trojanowski

Journal: JAMA Neurol. 2014 Apr;71(4):412-20.

 

Alzheimer disease (AD) is a neurodegenerative disorder with no effective therapies. In 1984, the National Institute on Aging created the first 5 AD centers (ADCs) in an effort to coordinate research efforts into the pathology and treatment of the disease. Since that time, the ADC ...

Last Updated: 15 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Alzheimer Disease" returned 183 free, full-text review articles on human participants. First 3 results:

[Diabetes type 2 and Alzheimer disease - one or two diseases? Mechanisms of association].
 

Author(s): Małgorzata Marszałek

Journal:

 

Some epidemiological data and pathophysiological evidence suggest similarities and connection of two amyloidoses: diabetes mellitus type 2, (DM2) (non-insulin dependent diabetes mellitus, NIDDM) and Alzheimer's disease (AD). What they have in common is insulin resistance, neurodegeneration, ...

Last Updated: 10 Sep 2013

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Imaging markers for Alzheimer disease: which vs how.
 

Author(s): Giovanni B Frisoni, Martina Bocchetta, Gael Chételat, Gil D Rabinovici, Mony J de Leon, Jeffrey Kaye, Eric M Reiman, Philip Scheltens, Frederik Barkhof, Sandra E Black, David J Brooks, Maria C Carrillo, Nick C Fox, Karl Herholz, Agneta Nordberg, Clifford R Jack, William J Jagust, Keith A Johnson, Christopher C Rowe, Reisa A Sperling, William Thies, Lars-Olof Wahlund, Michael W Weiner, Patrizio Pasqualetti, Charles Decarli,

Journal: Neurology. 2013 Jul;81(5):487-500.

 

Revised diagnostic criteria for Alzheimer disease (AD) acknowledge a key role of imaging biomarkers for early diagnosis. Diagnostic accuracy depends on which marker (i.e., amyloid imaging, ¹⁸F-fluorodeoxyglucose [FDG]-PET, SPECT, MRI) as well as how it is measured ("metric": visual, ...

Last Updated: 30 Jul 2013

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Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease.
 

Author(s): Thomas E Willnow, Olav M Andersen

Journal: J. Cell. Sci.. 2013 Jul;126(Pt 13):2751-60.

 

Excessive proteolytic breakdown of the amyloid precursor protein (APP) to neurotoxic amyloid β peptides (Aβ) by secretases in the brain is a molecular cause of Alzheimer disease (AD). According to current concepts, the complex route whereby APP moves between the secretory compartment, ...

Last Updated: 2 Jul 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Alzheimer's Disease Genetics Study
 

Status: Recruiting

Condition Summary: Alzheimer Disease; Late Onset Alzheimer Disease; Dementia

 

Last Updated: 3 Apr 2013

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Sleep Apnea in Early to Mid-Stage Alzheimer's Disease
 

Status: Recruiting

Condition Summary: Early Onset Alzheimer Disease; Alzheimer Disease; Obstructive Sleep Apnea Syndromes

 

Last Updated: 17 Jan 2014

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