Alzheimer's Disease

Common Name(s)

Alzheimer's Disease

Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. Alzheimer disease currently affects about 5 million people. About 75 percent of Alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. Although the cause of these cases is unknown, genetic changes are likely to play a role. Virtually all sporadic Alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older. The remaining cases of Alzheimer disease are familial, which means they are found in multiple members of a family. Familial Alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alzheimer's Disease" for support, advocacy or research.

Alzheimer's Association

The mission of the Alzheimer's Association is to eliminate Alzheimer's disease through the advancement of research; to provide and enhance care and support for all affected; and to reduce the risk of dementia through the promotion of brain health.

Last Updated: 11 Feb 2013

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Alzheimer's Disease Education and Referral Center

The Alzheimer's Disease Education and Referral Center was established by the National Institute on Aging (NIA) to provide information to health professionals, patients and their families and the public about Alzheimer's disease and other memory disorders.

Last Updated: 30 Oct 2014

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Alzheimer's Foundation of America

To provide optimal care and services to individuals confronting dementia, and to their caregivers and families--through member organizations dedicated to improving quality of life.

Last Updated: 9 Apr 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 3 Oct 2013

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

Last Updated: 20 Dec 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alzheimer's Disease" for support, advocacy or research.

Alzheimer's Association

The mission of the Alzheimer's Association is to eliminate Alzheimer's disease through the advancement of research; to provide and enhance care and support for all affected; and to reduce the risk of dementia through the promotion of brain health.

http://www.alz.org

Last Updated: 11 Feb 2013

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Alzheimer's Disease Education and Referral Center

The Alzheimer's Disease Education and Referral Center was established by the National Institute on Aging (NIA) to provide information to health professionals, patients and their families and the public about Alzheimer's disease and other memory disorders.

http://www.nia.nih.gov/alzheimers

Last Updated: 30 Oct 2014

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Alzheimer's Foundation of America

To provide optimal care and services to individuals confronting dementia, and to their caregivers and families--through member organizations dedicated to improving quality of life.

http://www.alzfdn.org

Last Updated: 9 Apr 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 3 Oct 2013

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

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General Support Organizations

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General Resources

Alzheimer's Association Helpline

The Alzheimer's Association 24/7 Helpline provides reliable information and support to all those who need assistance. Call us toll-free anytime day or night at 800.272.3900. Our 24/7 Helpline serves people with memory loss, caregivers, health care professionals and the public.

Updated 15 Oct 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Alzheimer's Disease" returned 4211 free, full-text research articles on human participants. First 3 results:

Benzodiazepine use and risk of Alzheimer's disease: case-control study.
 

Author(s): Sophie Billioti de Gage, Yola Moride, Thierry Ducruet, Tobias Kurth, Hélène Verdoux, Marie Tournier, Antoine Pariente, Bernard Bégaud

Journal:

 

To investigate the relation between the risk of Alzheimer's disease and exposure to benzodiazepines started at least five years before, considering both the dose-response relation and prodromes (anxiety, depression, insomnia) possibly linked with treatment.

Last Updated: 11 Sep 2014

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Effect of yizhitongxuan decoction on learning and memory ability, Gaq/11 expression and Na(+)-K(+)-ATP enzyme activity in rat models of Alzheimer's disease.
 

Author(s): Jing Teng, Zhexue Xu, Jing Zhang, Jingmin Li

Journal: J Tradit Chin Med. 2014 Aug;34(4):470-6.

 

To study the effects of Yizhitongxuan decoction on learning and memory abilities, Gaq/11 expression and Na(+)-K(+)-ATP enzyme activity in rat models of Alzheimer's disease (AD) caused by injecting Abeta25-35 into the hippocampus.

Last Updated: 4 Sep 2014

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Health care resource utilisation in primary care prior to and after a diagnosis of Alzheimer's disease: a retrospective, matched case-control study in the United Kingdom.
 

Author(s): Lei Chen, Catherine Reed, Michael Happich, Allen Nyhuis, Alan Lenox-Smith

Journal:

 

This study examined medical resource utilisation patterns in the United Kingdom (UK) prior to and following Alzheimer's disease (AD) diagnosis.

Last Updated: 28 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Alzheimer's Disease" returned 1010 free, full-text review articles on human participants. First 3 results:

Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.
 

Author(s): Carlos P Fitzsimons, Emma van Bodegraven, Marijn Schouten, Roy Lardenoije, Konstantinos Kompotis, Gunter Kenis, Mark van den Hurk, Marco P Boks, Caroline Biojone, Samia Joca, Harry W M Steinbusch, Katie Lunnon, Diego F Mastroeni, Jonathan Mill, Paul J Lucassen, Paul D Coleman, Daniel L A van den Hove, Bart P F Rutten

Journal:

 

Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mechanisms. These control the expression of specific sets of genes, often including ...

Last Updated: 4 Jul 2014

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Signaling pathway cross talk in Alzheimer's disease.
 

Author(s): Juan A Godoy, Juvenal A Rios, Juan M Zolezzi, Nady Braidy, Nibaldo C Inestrosa

Journal:

 

Numerous studies suggest energy failure and accumulative intracellular waste play a causal role in the pathogenesis of several neurodegenerative disorders and Alzheimer's disease (AD) in particular. AD is characterized by extracellular amyloid deposits, intracellular neurofibrillary ...

Last Updated: 8 Apr 2014

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Biological markers of Alzheimer's disease.
 

Author(s): Leonardo Cruz de Souza, Marie Sarazin, Antônio Lúcio Teixeira-Júnior, Paulo Caramelli, Antônio Emanuel dos Santos, Bruno Dubois

Journal: Arq Neuropsiquiatr. 2014 Mar;72(3):227-31.

 

The challenges for establishing an early diagnosis of Alzheimer's disease (AD) have created a need for biomarkers that reflect the core pathology of the disease. The cerebrospinal fluid (CSF) levels of total Tau (T-tau), phosphorylated Tau (P-Tau) and beta-amyloid peptide (Aβ₄₂) ...

Last Updated: 28 Mar 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Alzheimer's Disease Genetics Study
 

Status: Recruiting

Condition Summary: Alzheimer Disease; Late Onset Alzheimer Disease; Dementia

 

Last Updated: 3 Apr 2013

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Sleep Apnea in Early to Mid-Stage Alzheimer's Disease
 

Status: Recruiting

Condition Summary: Early Onset Alzheimer Disease; Alzheimer Disease; Obstructive Sleep Apnea Syndromes

 

Last Updated: 23 Jul 2014

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