Alzheimer Disease Familial

Common Name(s)

Alzheimer Disease Familial

Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. Alzheimer disease currently affects about 5 million people. About 75 percent of Alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. Although the cause of these cases is unknown, genetic changes are likely to play a role. Virtually all sporadic Alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older.

The remaining cases of Alzheimer disease are familial, which means they are found in multiple members of a family. Familial Alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65).

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alzheimer Disease Familial" for support, advocacy or research.

Logo
National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

Last Updated: 20 Dec 2012

View Details
stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alzheimer Disease Familial" for support, advocacy or research.

Logo
National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

View Details
stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Alzheimer Disease Familial" returned 42 free, full-text research articles on human participants. First 3 results:

The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study.
 

Author(s): David M Cash, Gerard R Ridgway, Yuying Liang, Natalie S Ryan, Kirsi M Kinnunen, Thomas Yeatman, Ian B Malone, Tammie L S Benzinger, Clifford R Jack, Paul M Thompson, Bernardino F Ghetti, Andrew J Saykin, Colin L Masters, John M Ringman, Stephen P Salloway, Peter R Schofield, Reisa A Sperling, Nigel J Cairns, Daniel S Marcus, Chengjie Xiong, Randall J Bateman, John C Morris, Martin N Rossor, Sébastien Ourselin, Nick C Fox,

Journal: Neurology. 2013 Oct;81(16):1425-33.

 

To assess regional patterns of gray and white matter atrophy in familial Alzheimer disease (FAD) mutation carriers.

Last Updated: 15 Oct 2013

Go To URL
The pathogenic aβ43 is enriched in familial and sporadic Alzheimer disease.
 

Author(s): Anna Sandebring, Hedvig Welander, Bengt Winblad, Caroline Graff, Lars O Tjernberg

Journal: PLoS ONE. 2013 ;8(2):e55847.

 

The amyloid-cascade hypothesis posits that the role of amyloid β-peptide (Aβ) in Alzheimer disease (AD) involves polymerization into structures that eventually are deposited as amyloid plaques. During this process, neurotoxic oligomers are formed that induce synaptic loss and neuronal ...

Last Updated: 14 Feb 2013

Go To URL
Exploratory data from complete genomes of familial alzheimer disease age-at-onset outliers.
 

Author(s): Matthew A Lalli, Gloria Garcia, Lucia Madrigal, Mauricio Arcos-Burgos, Mary Luz Arcila, Kenneth S Kosik, Francisco Lopera

Journal: Hum. Mutat.. 2012 Dec;33(12):1630-4.

 

Identifying genes that modify the age at onset (AAO) of Alzheimer disease and targeting them pharmacologically represent a potential treatment strategy. In this exploratory study, we sequenced the complete genomes of six individuals with familial Alzheimer disease due to the autosomal ...

Last Updated: 12 Nov 2012

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Alzheimer Disease Familial" returned 0 free, full-text review articles on human participants.

 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Alzheimer's Disease Genetics Study
 

Status: Recruiting

Condition Summary: Alzheimer Disease; Late Onset Alzheimer Disease; Dementia

 

Last Updated: 3 Apr 2013

Go to URL
Wii-Fit For Improving Activity, Gait And Balance In Alzheimer's Dementia
 

Status: Recruiting

Condition Summary: Alzheimer's Dementia; Falls; Gait Impairment; Balance Impairment

 

Last Updated: 1 Jun 2010

Go to URL