Alzheimer's Disease Familial

Common Name(s)

Alzheimer's Disease Familial

Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. Alzheimer disease currently affects about 5 million people. About 75 percent of Alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. Although the cause of these cases is unknown, genetic changes are likely to play a role. Virtually all sporadic Alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older.

The remaining cases of Alzheimer disease are familial, which means they are found in multiple members of a family. Familial Alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65).

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alzheimer's Disease Familial" for support, advocacy or research.

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Alzheimer's Disease Education and Referral Center

The Alzheimer's Disease Education and Referral Center was established by the National Institute on Aging (NIA) to provide information to health professionals, patients and their families and the public about Alzheimer's disease and other memory disorders.

Last Updated: 30 Oct 2014

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

Last Updated: 20 Dec 2012

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alzheimer's Disease Familial" for support, advocacy or research.

Logo
Alzheimer's Disease Education and Referral Center

The Alzheimer's Disease Education and Referral Center was established by the National Institute on Aging (NIA) to provide information to health professionals, patients and their families and the public about Alzheimer's disease and other memory disorders.

http://www.nia.nih.gov/alzheimers

Last Updated: 30 Oct 2014

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Alzheimer's Disease Familial" returned 107 free, full-text research articles on human participants. First 3 results:

Abundance of Aβ₅-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease.
 

Author(s): Erika Avendaño Guzmán, Yvonne Bouter, Bernhard C Richard, Lars Lannfelt, Martin Ingelsson, Anders Paetau, Auli Verkkoniemi-Ahola, Oliver Wirths, Thomas A Bayer

Journal:

 

According to the modified amyloid hypothesis the main event in the pathogenesis of Alzheimer's disease (AD) is the deposition of neurotoxic amyloid β-peptide (Aβ) within neurons. Additionally to full-length peptides, a great diversity of N-truncated Aβ variants is derived from ...

Last Updated: 8 Apr 2014

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Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis.
 

Author(s): Diego Sepulveda-Falla, Alvaro Barrera-Ocampo, Christian Hagel, Anne Korwitz, Maria Fernanda Vinueza-Veloz, Kuikui Zhou, Martijn Schonewille, Haibo Zhou, Luis Velazquez-Perez, Roberto Rodriguez-Labrada, Andres Villegas, Isidro Ferrer, Francisco Lopera, Thomas Langer, Chris I De Zeeuw, Markus Glatzel

Journal: J. Clin. Invest.. 2014 Apr;124(4):1552-67.

 

Familial Alzheimer's disease (FAD) is characterized by autosomal dominant heritability and early disease onset. Mutations in the gene encoding presenilin-1 (PS1) are found in approximately 80% of cases of FAD, with some of these patients presenting cerebellar damage with amyloid plaques ...

Last Updated: 2 Apr 2014

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Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease.
 

Author(s): Scott A Wilke, Tara Raam, Joseph K Antonios, Eric A Bushong, Edward H Koo, Mark H Ellisman, Anirvan Ghosh

Journal:

 

The earliest stages of Alzheimer's disease (AD) are characterized by deficits in memory and cognition indicating hippocampal pathology. While it is now recognized that synapse dysfunction precedes the hallmark pathological findings of AD, it is unclear if specific hippocampal synapses ...

Last Updated: 23 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Alzheimer's Disease Familial" returned 3 free, full-text review articles on human participants. First 3 results:

Correlating familial Alzheimer's disease gene mutations with clinical phenotype.
 

Author(s): Natalie S Ryan, Martin N Rossor

Journal: Biomark Med. 2010 Feb;4(1):99-112.

 

Alzheimer's disease (AD) causes devastating cognitive impairment and an intense research effort is currently devoted to developing improved treatments for it. A minority of cases occur at a particularly young age and are caused by autosomal dominantly inherited genetic mutations. ...

Last Updated: 13 Apr 2010

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Sequence analyses of presenilin mutations linked to familial Alzheimer's disease.
 

Author(s): Sun Don Kim, Jinoh Kim

Journal: Cell Stress Chaperones. 2008 Dec;13(4):401-12.

 

Familial Alzheimer's disease (FAD)-linked presenilin (PS) mutations show gain-of-toxic-function characteristics. These FAD PS mutations are scattered throughout the PS molecule, reminiscent of the distribution of cystic fibrosis transmembrane conductance regulator and p53 mutations. ...

Last Updated: 21 Oct 2008

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Genetic basis of neurodegeneration in familial Alzheimer's disease.
 

Author(s): Anna Kowalska

Journal: Pol J Pharmacol. ;56(2):171-8.

 

Alzheimer's disease (AD), the most common form of dementia, is characterized by two types of brain lesions, referred to as senile plaques and neurofibrillary tangles. Moreover, neuronal cell loss and synaptic degeneration appear in affected regions of the brain. A series of endoproteolytic ...

Last Updated: 24 May 2004

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Alzheimer's Disease Genetics Study
 

Status: Recruiting

Condition Summary: Alzheimer Disease; Late Onset Alzheimer Disease; Dementia

 

Last Updated: 3 Apr 2013

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Wii-Fit For Improving Activity, Gait And Balance In Alzheimer's Dementia
 

Status: Recruiting

Condition Summary: Alzheimer's Dementia; Falls; Gait Impairment; Balance Impairment

 

Last Updated: 1 Jun 2010

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