Afibrinogenemia

Common Name(s)

Afibrinogenemia

Afibrinogenemia, sometimes called congenital afibrinogenemia, is an inherited blood disorder in which the blood does not clot normally. It occurs when there is a lack (deficiency) of a protein called fibrinogen (or factor I), which is needed for the blood to clot.  Affected individuals may be susceptible to severe bleeding (hemorrhaging) episodes, particularly during infancy and childhood. Afibrinogenemia is thought to be transmitted as an autosomal recessive trait.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Afibrinogenemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Afibrinogenemia" returned 29 free, full-text research articles on human participants. First 3 results:

Chronic subdural hematoma in a patient with congenital afibrinogenemia successfully treated with fibrinogen replacement.
 

Author(s): Naoto Sakai, Soichi Akamine, Tsutomu Tokuyama, Kenji Sugiyama, Naohiro Kanayama, Hiroki Namba

Journal: Neurol. Med. Chir. (Tokyo). 2011 ;51(11):780-3.

 

A 37-year-old woman with congenital afibrinogenemia presented with chronic subdural hematoma (CSDH) manifesting as severe headache, nausea, and somnolence after a minor head trauma. Brain computed tomography scans showed a right subdural hematoma associated with midline shift. Laboratory ...

Last Updated: 29 Nov 2011

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Cellulitis on face in a patient with congenital afibrinogenemia.
 

Author(s): G D Chandan, A G Annaji, S Bhatnagar, U Mohandas, P Dave

Journal: J Indian Soc Pedod Prev Dent. ;29(1):46-9.

 

Congenital afibrinogenemia is a rare coagulation disorder, with an estimated prevalence of 1 : 1,000,000, characterized by a complete absence to reduced level of circulating fibrinogen. This article presents a case of congenital afibrinogenemia, which presented as cellulitis on the face.

Last Updated: 27 Apr 2011

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[The congenital afibrinogenemia: case report].
 

Author(s): Imen Brahem, Bassem Charfeddine, Haythem Chraiti, Jihene Ben Abdallah, Leila Ben Othmen, Souhir Neffati, Mohamed Ali Smach, Affef Ltaief, Monia Ksourri, Hedi Dridi, Khalifa Limem

Journal: Ann. Biol. Clin. (Paris). ;68(5):595-7.

 

The deficiency in factor I or fibrinogen is a largely unknown genetic disease. It is a rare condition inherited as an autosomal recessive, whose clinical events are variable, ranging from moderate to minimal bleeding or cataclysmic hemorrhage. We report a case of congenital afibrinogenemia ...

Last Updated: 27 Sep 2010

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Afibrinogenemia" returned 1 free, full-text review articles on human participants. First 3 results:

[Congenital afibrinogenemia].
 

Author(s): P Pastilha, L Coelho, T D Costa, G Deus, H Santos, A Rosa, F Barrocas, L Braga

Journal: Acta Med Port. 1998 Dec;11(12):1117-9.

 

The authors present a case of congenital afibrinogenemia. A review of the literature is made, and some aspects of this rare inherited coagulation disorder are suggested and commented on.

Last Updated: 30 Apr 1999

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Fibrinogen Concentrate (Human) − Efficacy and Safety Study
 

Status: Recruiting

Condition Summary: Afibrinogenemia; Hypofibrinogenemia; Fibrinogen Deficiency

 

Last Updated: 29 Jan 2014

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Pharmacokinetic, Efficacy, and Safety Study of Octafibrin Compared to Haemocomplettan/Riastap
 

Status: Recruiting

Condition Summary: Congenital Fibrinogen Deficiency; Afibrinogenemia

 

Last Updated: 10 Jan 2014

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Pharmacokinetic, Efficacy and Safety of BT524 in Patients With Congenital Fibrinogen Deficiency
 

Status: Recruiting

Condition Summary: Congenital Afibrinogenemia; Congenital Hypofibrinogenemia

 

Last Updated: 17 Feb 2014

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