Adenosine Deaminase Deficiency

Common Name(s)

Adenosine Deaminase Deficiency, Severe combined immunodeficiency due to ADA deficiency

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenosine Deaminase Deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adenosine Deaminase Deficiency" returned 68 free, full-text research articles on human participants. First 3 results:

Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans.
 

Author(s): Fabio Candotti, Kit L Shaw, Linda Muul, Denise Carbonaro, Robert Sokolic, Christopher Choi, Shepherd H Schurman, Elizabeth Garabedian, Chimene Kesserwan, G Jayashree Jagadeesh, Pei-Yu Fu, Eric Gschweng, Aaron Cooper, John F Tisdale, Kenneth I Weinberg, Gay M Crooks, Neena Kapoor, Ami Shah, Hisham Abdel-Azim, Xiao-Jin Yu, Monika Smogorzewska, Alan S Wayne, Howard M Rosenblatt, Carla M Davis, Celine Hanson, Radha G Rishi, Xiaoyan Wang, David Gjertson, Otto O Yang, Arumugam Balamurugan, Gerhard Bauer, Joanna A Ireland, Barbara C Engel, Gregory M Podsakoff, Michael S Hershfield, R Michael Blaese, Robertson Parkman, Donald B Kohn

Journal: Blood. 2012 Nov;120(18):3635-46.

 

We conducted a gene therapy trial in 10 patients with adenosine deaminase (ADA)-deficient severe combined immunodeficiency using 2 slightly different retroviral vectors for the transduction of patients' bone marrow CD34(+) cells. Four subjects were treated without pretransplantation ...

Last Updated: 2 Nov 2012

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Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy.
 

Author(s): Aisha V Sauer, Henner Morbach, Immacolata Brigida, Yen-Shing Ng, Alessandro Aiuti, Eric Meffre

Journal: J. Clin. Invest.. 2012 Jun;122(6):2141-52.

 

Adenosine deaminase (ADA) gene defects are among the most common causes of SCID. Restoration of purine metabolism and immune functions can be achieved by enzyme replacement therapy, or more effectively by bone marrow transplant or HSC gene therapy (HSC-GT). However, autoimmune complications ...

Last Updated: 1 Jun 2012

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Pillars article: Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity. The Lancet. 1972. 300: 1067-1069.
 

Author(s): Eloise R Giblett, Jeanne E Anderson, Flossie Cohen, Bernard Pollara, Hilaire J Meuwissen

Journal: J. Immunol.. 2012 Feb;188(3):936-8.

 

Last Updated: 20 Jan 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adenosine Deaminase Deficiency" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gene Therapy ADA Deficiency
 

Status: Recruiting

Condition Summary: Adenosine Deaminase Deficiency

 

Last Updated: 1 Mar 2012

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EZN-2279 in Patients With ADA-SCID
 

Status: Recruiting

Condition Summary: ADA-SCID; Adenosine Deaminase Deficiency; Severe Combined Immunodeficiency

 

Last Updated: 17 Dec 2013

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