Acute Promyelocytic Leukemia

Common Name(s)

Acute Promyelocytic Leukemia

Acute promyelocytic leukemia is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by a translocation of chromosomes 15 and 17. Acute promyelocytic leukemia usually occurs in middle-aged adults. Symptoms may include both bleeding and forming blood clots.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Promyelocytic Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Promyelocytic Leukemia" returned 761 free, full-text research articles on human participants. First 3 results:

Effects of Fifty-Hertz Electromagnetic Fields on Granulocytic Differentiation of ATRA-Treated Acute Promyelocytic Leukemia NB4 Cells.
 

Author(s): Alfredo Errico Provenzano, Stefano Amatori, Maria Gemma Nasoni, Giuseppe Persico, Sergio Russo, Anna Rita Mastrogiacomo, Alessandro Gambarara, Mirco Fanelli

Journal: Cell. Physiol. Biochem.. 2018 ;46(1):389-400.

 

Life on Earth is constantly exposed to electromagnetic fields (EMFs) and the effects induced by EMFs on biological systems have been extensively studied producing different and sometimes contradictory results. Extremely low-frequency electromagnetic fields (ELF-EMFs) have shown to ...

Last Updated: 31 Dec 1969

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Case report: Purulent transformation of granulocytic sarcoma: An unusual pattern of differentiation in acute promyelocytic leukemia.
 

Author(s): Elodie Collinge, Isabelle Tigaud, Brigitte Balme, Luc-Marie Gerland, Pierre Sujobert, Violette Carlioz, Gilles Salles, Xavier Thomas, Etienne Paubelle

Journal: Medicine (Baltimore). 2018 Feb;97(8):e9657.

 

Acute promyelocytic leukemia (APL) is a curable subtype of acute myeloid leukemia. APL is currently treated with combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) resulting in the induction of apoptosis and differentiation of the leukemic cells. Differentiation ...

Last Updated: 31 Dec 1969

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Analysis of early death in newly diagnosed acute promyelocytic leukemia patients.
 

Author(s): Fang Xu, Chunli Wang, Changxin Yin, Xuejie Jiang, Ling Jiang, Zhixiang Wang, Fanyi Meng

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9324.

 

The aim of this study was to identify risk factors for early death (ED) in acute promyelocitic leukemia (APL) patients.Clinical records of 49 APL patients who suffered ED were divided into 4 groups: death before treatment or within the first 3 days (immediate death; iED group), death ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Promyelocytic Leukemia" returned 71 free, full-text review articles on human participants. First 3 results:

Acute promyelocytic leukemia with cryptic t(15;17) on isochromosome 17: a case report and review of literature.
 

Author(s): Yuting Tang, Ying Wang, Liang Hu, Fankai Meng, Danmei Xu, Kai Wan, Lifang Huang, Chunrui Li, Jianfeng Zhou

Journal:

 

Acute Promyelocytic Leukemia (APL) is one of the most curable leukemia which shows great sensitivity to all-trans retinoic acid (ATRA) although a small number of the patients present poor prognosis and short survival. Isochromosome 17 in APL which usually bears an additional copy ...

Last Updated: 31 Dec 1969

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The evolution of arsenic in the treatment of acute promyelocytic leukemia and other myeloid neoplasms: Moving toward an effective oral, outpatient therapy.
 

Author(s): Lorenzo Falchi, Srdan Verstovsek, Farhad Ravandi-Kashani, Hagop M Kantarjian

Journal: Cancer. 2016 Apr;122(8):1160-8.

 

The therapeutic potential of arsenic derivatives has long been recognized and was recently rediscovered in modern literature. Early studies demonstrated impressive activity of this compound in patients with relapsed acute promyelocytic leukemia (APL). Over the last 2 decades, intravenous ...

Last Updated: 31 Dec 1969

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Acute promyelocytic leukemia: where did we start, where are we now, and the future.
 

Author(s): C C Coombs, M Tavakkoli, M S Tallman

Journal:

 

Historically, acute promyelocytic leukemia (APL) was considered to be one of the most fatal forms of acute leukemia with poor outcomes before the introduction of the vitamin A derivative all-trans retinoic acid (ATRA). With considerable advances in therapy, including the introduction ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Long-term QoL in Acute Promyelocytic Leukemia Treated With ATO or Standard Chemotherapy
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 11 Oct 2017

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Treatment of Non-high-risk Acute Promyelocytic Leukemia (APL) With Realgar-Indigo Naturalis Formula (RIF)
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 13 Sep 2016

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Role of Microparticles in the Coagulopathy of Acute Promyelocytic Leukemia
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 22 Apr 2018

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