Acute Promyelocytic Leukemia

Common Name(s)

Acute Promyelocytic Leukemia

Acute promyelocytic leukemia is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by a translocation of chromosomes 15 and 17. Acute promyelocytic leukemia usually occurs in middle-aged adults. Symptoms may include both bleeding and forming blood clots.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Promyelocytic Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Promyelocytic Leukemia" returned 745 free, full-text research articles on human participants. First 3 results:

Effect of ATRA and ATO on the expression of tissue factor in NB4 acute promyelocytic leukemia cells and regulatory function of the inflammatory cytokines TNF and IL-1β.
 

Author(s): Sylvie Dunoyer-Geindre, Anne-Sophie Rivier-Cordey, Olga Tsopra, Thomas Lecompte, Egbert K O Kruithof

Journal: Ann. Hematol.. 2017 Jun;96(6):905-917.

 

The characteristic hemorrhages of acute promyelocytic leukemia (APL) are caused in part by the high expression of tissue factor (TF) on leukemic cells, which also produce TNF and IL-1β, proinflammatory cytokines known to increase TF in various cell types. Exposure of NB4 cells, an ...

Last Updated: 26 Mar 2017

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Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia.
 

Author(s): Julia Abramowitz, Tzahi Neuman, Riki Perlman, Dina Ben-Yehuda

Journal:

 

Mechanisms that inactivate the p53 pathway in Acute Myeloid Leukemia (AML), other than rare mutations, are still not well understood.

Last Updated: 25 Mar 2017

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Acute WT1-positive promyelocytic leukemia with hypogranular variant morphology, bcr-3 isoform of PML-RARα and Flt3-ITD mutation: a rare case report.
 

Author(s): Xi Zhang, Cheng Yang, Xiangui Peng, Xinghua Chen, Yimei Feng

Journal: Sao Paulo Med J. ;135(2):179-184.

 

Acute promyelocytic leukemia (APL) accounts for 8% to 10% of cases of acute myeloid leukemia (AML). Remission in cases of high-risk APL is still difficult to achieve, and relapses occur readily.

Last Updated: 26 Jan 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Promyelocytic Leukemia" returned 75 free, full-text review articles on human participants. First 3 results:

Acute promyelocytic leukemia with cryptic t(15;17) on isochromosome 17: a case report and review of literature.
 

Author(s): Yuting Tang, Ying Wang, Liang Hu, Fankai Meng, Danmei Xu, Kai Wan, Lifang Huang, Chunrui Li, Jianfeng Zhou

Journal:

 

Acute Promyelocytic Leukemia (APL) is one of the most curable leukemia which shows great sensitivity to all-trans retinoic acid (ATRA) although a small number of the patients present poor prognosis and short survival. Isochromosome 17 in APL which usually bears an additional copy ...

Last Updated: 29 Jan 2016

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The evolution of arsenic in the treatment of acute promyelocytic leukemia and other myeloid neoplasms: Moving toward an effective oral, outpatient therapy.
 

Author(s): Lorenzo Falchi, Srdan Verstovsek, Farhad Ravandi-Kashani, Hagop M Kantarjian

Journal: Cancer. 2016 Apr;122(8):1160-8.

 

The therapeutic potential of arsenic derivatives has long been recognized and was recently rediscovered in modern literature. Early studies demonstrated impressive activity of this compound in patients with relapsed acute promyelocytic leukemia (APL). Over the last 2 decades, intravenous ...

Last Updated: 11 Apr 2016

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Acute promyelocytic leukemia: where did we start, where are we now, and the future.
 

Author(s): C C Coombs, M Tavakkoli, M S Tallman

Journal:

 

Historically, acute promyelocytic leukemia (APL) was considered to be one of the most fatal forms of acute leukemia with poor outcomes before the introduction of the vitamin A derivative all-trans retinoic acid (ATRA). With considerable advances in therapy, including the introduction ...

Last Updated: 18 Apr 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Long-term QoL in Acute Promyelocytic Leukemia Treated With ATO or Standard Chemotherapy
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 11 Oct 2017

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Treatment of Non-high-risk Acute Promyelocytic Leukemia (APL) With Realgar-Indigo Naturalis Formula (RIF)
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 13 Sep 2016

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Role of Microparticles in the Coagulopathy of Acute Promyelocytic Leukemia
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 8 Dec 2016

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