Acute Promyelocytic Leukemia

Common Name(s)

Acute Promyelocytic Leukemia

Acute promyelocytic leukemia is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by a translocation of chromosomes 15 and 17. Acute promyelocytic leukemia usually occurs in middle-aged adults. Symptoms may include both bleeding and forming blood clots.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Promyelocytic Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Promyelocytic Leukemia" returned 735 free, full-text research articles on human participants. First 3 results:

Acute Promyelocytic Leukemia with i(17)(q10).
 

Author(s): Junki Inamura, Katsuya Ikuta, Nodoka Tsukada, Takaaki Hosoki, Motohiro Shindo, Kazuya Sato

Journal: Intern. Med.. ;55(22):3341-3345.

 

We herein report a rare chromosomal abnormality observed in an acute promyelocytic leukemia (APL) patient. She had several APL derivative clones including a clone with i(17)(q10) abnormality, which consists of two kinds of structural abnormalities, a cryptic translocation of t(15;17) ...

Last Updated: 17 Nov 2016

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NLS‑RARα modulates acute promyelocytic leukemia NB4 cell proliferation and differentiation via the PI3K/AKT pathway.
 

Author(s): Hao Song, Liu Li, Liang Zhong, Rong Yang, Kailing Jiang, Xiaoqun Yang, Beizhong Liu

Journal: Mol Med Rep. 2016 Dec;14(6):5495-5500.

 

In patients with acute promyelocytic leukemia (APL), ~98% express the promyelocytic leukemia (PML)‑retinoic acid receptor α (RARα) fusion protein. Previous studies have shown that, in primary leukemia cells of patients with APL, the cleavage of PML‑RARα by neutrophil elastase ...

Last Updated: 14 Nov 2016

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Cell Population Data NE-SFL and MO-WX From Sysmex XN-3000 Can Provide Additional Information for Exclusion of Acute Promyelocytic Leukemia From Other Acute Myeloid Leukemias: A Preliminary Study.
 

Author(s): Sang Hyuk Park, Hyung Hoi Kim, In Suk Kim, Jongyoun Yi, Chulhun L Chang, Eun Yup Lee

Journal: Ann Lab Med. 2016 Nov;36(6):607-10.

 

Last Updated: 31 Aug 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Promyelocytic Leukemia" returned 77 free, full-text review articles on human participants. First 3 results:

Acute promyelocytic leukemia with cryptic t(15;17) on isochromosome 17: a case report and review of literature.
 

Author(s): Yuting Tang, Ying Wang, Liang Hu, Fankai Meng, Danmei Xu, Kai Wan, Lifang Huang, Chunrui Li, Jianfeng Zhou

Journal:

 

Acute Promyelocytic Leukemia (APL) is one of the most curable leukemia which shows great sensitivity to all-trans retinoic acid (ATRA) although a small number of the patients present poor prognosis and short survival. Isochromosome 17 in APL which usually bears an additional copy ...

Last Updated: 29 Jan 2016

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The evolution of arsenic in the treatment of acute promyelocytic leukemia and other myeloid neoplasms: Moving toward an effective oral, outpatient therapy.
 

Author(s): Lorenzo Falchi, Srdan Verstovsek, Farhad Ravandi-Kashani, Hagop M Kantarjian

Journal: Cancer. 2016 Apr;122(8):1160-8.

 

The therapeutic potential of arsenic derivatives has long been recognized and was recently rediscovered in modern literature. Early studies demonstrated impressive activity of this compound in patients with relapsed acute promyelocytic leukemia (APL). Over the last 2 decades, intravenous ...

Last Updated: 11 Apr 2016

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Acute promyelocytic leukemia: where did we start, where are we now, and the future.
 

Author(s): C C Coombs, M Tavakkoli, M S Tallman

Journal:

 

Historically, acute promyelocytic leukemia (APL) was considered to be one of the most fatal forms of acute leukemia with poor outcomes before the introduction of the vitamin A derivative all-trans retinoic acid (ATRA). With considerable advances in therapy, including the introduction ...

Last Updated: 18 Apr 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Long-term QoL in Acute Promyelocytic Leukemia Treated With ATO or Standard Chemotherapy
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 23 May 2017

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Treatment of Non-high-risk Acute Promyelocytic Leukemia (APL) With Realgar-Indigo Naturalis Formula (RIF)
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 13 Sep 2016

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Role of Microparticles in the Coagulopathy of Acute Promyelocytic Leukemia
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 8 Dec 2016

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