Acute Promyelocytic Leukemia

Common Name(s)

Acute Promyelocytic Leukemia

Acute promyelocytic leukemia is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by a translocation of chromosomes 15 and 17. Acute promyelocytic leukemia usually occurs in middle-aged adults. Symptoms may include both bleeding and forming blood clots.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Promyelocytic Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Promyelocytic Leukemia" returned 777 free, full-text research articles on human participants. First 3 results:

Targeted Therapy Alone for Acute Promyelocytic Leukemia.
 

Author(s): Francesco Lo-Coco, Laura Di Donato, , Richard F Schlenk,

Journal: N. Engl. J. Med.. 2016 Mar;374(12):1197-8.

 

Last Updated: 24 Mar 2016

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The Mutational Landscape of Acute Promyelocytic Leukemia Reveals an Interacting Network of Co-Occurrences and Recurrent Mutations.
 

Author(s): Mariam Ibáñez, José Carbonell-Caballero, Luz García-Alonso, Esperanza Such, Jorge Jiménez-Almazán, Enrique Vidal, Eva Barragán, María López-Pavía, Marta LLop, Iván Martín, Inés Gómez-Seguí, Pau Montesinos, Miguel A Sanz, Joaquín Dopazo, José Cervera

Journal:

 

Preliminary Acute Promyelocytic Leukemia (APL) whole exome sequencing (WES) studies have identified a huge number of somatic mutations affecting more than a hundred different genes mainly in a non-recurrent manner, suggesting that APL is a heterogeneous disease with secondary relevant ...

Last Updated: 18 Feb 2016

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Addition of Arsenic Trioxide into Induction Regimens Could Not Accelerate Recovery of Abnormality of Coagulation and Fibrinolysis in Patients with Acute Promyelocytic Leukemia.
 

Author(s): Ye Zhang, SiJing Wu, Dan Luo, JianFeng Zhou, DengJu Li

Journal:

 

All-trans retinoic acid combined to anthracycline-based chemotherapy is the standard regimen of acute promyelocytic leukemia. The advent of arsenic trioxide has contributed to improve the anti-leukemic efficacy in acute promyelocytic leukemia. The objectives of the current study were ...

Last Updated: 27 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Promyelocytic Leukemia" returned 76 free, full-text review articles on human participants. First 3 results:

Acute promyelocytic leukemia: where did we start, where are we now, and the future.
 

Author(s): C C Coombs, M Tavakkoli, M S Tallman

Journal:

 

Historically, acute promyelocytic leukemia (APL) was considered to be one of the most fatal forms of acute leukemia with poor outcomes before the introduction of the vitamin A derivative all-trans retinoic acid (ATRA). With considerable advances in therapy, including the introduction ...

Last Updated: 18 Apr 2015

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Global characteristics of childhood acute promyelocytic leukemia.
 

Author(s): L Zhang, A Samad, M S Pombo-de-Oliveira, G Scelo, M T Smith, J Feusner, J L Wiemels, C Metayer

Journal: Blood Rev.. 2015 Mar;29(2):101-25.

 

Acute promyelocytic leukemia (APL) comprises approximately 5-10% of childhood acute myeloid leukemia (AML) cases in the US. While variation in this percentage among other populations was noted previously, global patterns of childhood APL have not been thoroughly characterized. In ...

Last Updated: 3 Apr 2015

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New strategies in acute promyelocytic leukemia: moving to an entirely oral, chemotherapy-free upfront management approach.
 

Author(s): Amer M Zeidan, Steven D Gore

Journal: Clin. Cancer Res.. 2014 Oct;20(19):4985-93.

 

Incorporation of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) into the management paradigms of acute promyelocytic leukemia (APL) has markedly improved outcomes. Significant progress occurred in understanding the molecular pathogenesis of APL. ATO, in contrast with ATRA, ...

Last Updated: 2 Oct 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment Protocol for Relapsed Acute Promyelocytic Leukemia (APL) With Arsenic
 

Status: Recruiting

Condition Summary: Relapsed Acute Promyelocytic Leukemia; Refractory Acute Promyelocytic Leukemia

 

Last Updated: 22 Oct 2007

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Gemtuzumab Ozogamicin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Acute Promyelocytic Leukemia
 

Status: Recruiting

Condition Summary: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Promyelocytic Leukemia (M3); Childhood Acute Promyelocytic Leukemia (M3); Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Myeloid Leukemia

 

Last Updated: 26 Jul 2016

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Study of NRX 195183 Therapy for Patients With Relapsed or Refractory Acute Promyelocytic Leukemia
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 9 May 2008

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