Acute Promyelocytic Leukemia

Common Name(s)

Acute Promyelocytic Leukemia

Acute promyelocytic leukemia is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by a translocation of chromosomes 15 and 17. Acute promyelocytic leukemia usually occurs in middle-aged adults. Symptoms may include both bleeding and forming blood clots.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Promyelocytic Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Promyelocytic Leukemia" returned 762 free, full-text research articles on human participants. First 3 results:

A Pediatric Acute Promyelocytic Leukemia With a Rare Karyotype of ider(17)(q10)t(15;17) and Favorable Outcome: A Case Report.
 

Author(s): Yanli He, Ping Wang, Kaiwei Liang, Xiangjun Chen, Wen Du, Juan Li, Yanjie Hu, Yan Bai, Wei Liu, Xiaoqing Li, Runming Jin, Min Zhang, Jine Zheng

Journal: Medicine (Baltimore). 2015 Oct;94(41):e1778.

 

Acute promyelocytic leukemia (APL) is a specific malignant hematological disorder with a diagnostic hallmark of chromosome translocation t(15;17)(q22;q21). As a very rare secondary cytogenetic aberration in pediatric APL, ider(17q) (q10)t(15;17) was suggested to be a poor prognostic ...

Last Updated: 16 Oct 2015

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High ΔNp73/TAp73 ratio is associated with poor prognosis in acute promyelocytic leukemia.
 

Author(s): Antonio R Lucena-Araujo, Haesook T Kim, Carolina Thomé, Rafael H Jacomo, Raul A Melo, Rosane Bittencourt, Ricardo Pasquini, Katia Pagnano, Ana Beatriz F Glória, Maria de Lourdes Chauffaille, Melina Athayde, Carlos S Chiattone, Ingrid Mito, Rodrigo Bendlin, Carmino Souza, Cristina Bortolheiro, Juan L Coelho-Silva, Stanley L Schrier, Martin S Tallman, David Grimwade, Arnold Ganser, Nancy Berliner, Raul C Ribeiro, Francesco Lo-Coco, Bob Löwenberg, Miguel A Sanz, Eduardo M Rego

Journal: Blood. 2015 Nov;126(20):2302-6.

 

The TP73 gene transcript is alternatively spliced and translated into the transcriptionally active (TAp73) or inactive (ΔNp73) isoforms, with opposite effects on the expression of p53 target genes and on apoptosis induction. The imbalance between ΔNp73 and TAp73 may contribute to ...

Last Updated: 13 Nov 2015

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Pseudotumour cerebri in acute promyelocytic leukemia on treatment with all-trans-retinoic acid (ATRA) - an experience from a tertiary care centre.
 

Author(s): Manzoor Ahmad Tali, Yasir Bashir, Shuaeb Bhat, Fahim Manzoor, Nusrat Bashir, Sajad Geelani, Javid Rasool, Abdul Waheed Mir

Journal: Malays J Pathol. 2015 Aug;37(2):141-4.

 

Acute promyelocytic leukemia (APML) is considered to be sensitive to all-trans-retinoic acid (ATRA) which acts as a differentiating agent. ATRA is considered to be a well-tolerated agent and is known to achieve complete remission in acute promyelocytic leukemia. However, a few cases ...

Last Updated: 17 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Promyelocytic Leukemia" returned 76 free, full-text review articles on human participants. First 3 results:

Acute promyelocytic leukemia: where did we start, where are we now, and the future.
 

Author(s): C C Coombs, M Tavakkoli, M S Tallman

Journal:

 

Historically, acute promyelocytic leukemia (APL) was considered to be one of the most fatal forms of acute leukemia with poor outcomes before the introduction of the vitamin A derivative all-trans retinoic acid (ATRA). With considerable advances in therapy, including the introduction ...

Last Updated: 18 Apr 2015

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Global characteristics of childhood acute promyelocytic leukemia.
 

Author(s): L Zhang, A Samad, M S Pombo-de-Oliveira, G Scelo, M T Smith, J Feusner, J L Wiemels, C Metayer

Journal: Blood Rev.. 2015 Mar;29(2):101-25.

 

Acute promyelocytic leukemia (APL) comprises approximately 5-10% of childhood acute myeloid leukemia (AML) cases in the US. While variation in this percentage among other populations was noted previously, global patterns of childhood APL have not been thoroughly characterized. In ...

Last Updated: 3 Apr 2015

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New strategies in acute promyelocytic leukemia: moving to an entirely oral, chemotherapy-free upfront management approach.
 

Author(s): Amer M Zeidan, Steven D Gore

Journal: Clin. Cancer Res.. 2014 Oct;20(19):4985-93.

 

Incorporation of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) into the management paradigms of acute promyelocytic leukemia (APL) has markedly improved outcomes. Significant progress occurred in understanding the molecular pathogenesis of APL. ATO, in contrast with ATRA, ...

Last Updated: 2 Oct 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment Protocol for Relapsed Acute Promyelocytic Leukemia (APL) With Arsenic
 

Status: Recruiting

Condition Summary: Relapsed Acute Promyelocytic Leukemia; Refractory Acute Promyelocytic Leukemia

 

Last Updated: 22 Oct 2007

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Gemtuzumab Ozogamicin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Acute Promyelocytic Leukemia
 

Status: Recruiting

Condition Summary: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Promyelocytic Leukemia (M3); Childhood Acute Promyelocytic Leukemia (M3); Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Myeloid Leukemia

 

Last Updated: 27 Jul 2015

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Study of NRX 195183 Therapy for Patients With Relapsed or Refractory Acute Promyelocytic Leukemia
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 9 May 2008

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