Acute lymphoblastic leukemia

Common Name(s)

Acute lymphoblastic leukemia, Acute lymphocytic leukemia

Acute lymphoblastic leukemia (ALL) is a quickly progressing (acute) cancer of the white blood cells. These white blood cells, also called lymphocytes, are produced in the bone marrow (inner part of the bones) and are part of our body’s immune system which fights infections. The bone marrow also makes red blood cells (which carry oxygen to all the cells of our body) and platelets (which help our blood clot). ALL occurs when cancerous, immature white blood cells are overproduced in the bone marrow, which limits the production of other blood cells, such as red blood cells and platelets. ALL is most common among children ages 2 through 5 and the elderly. The symptoms that result are fever, shortness of breath, coughing, chest pain, vomiting, increased bleeding, bleeding from the gums, and an increased risk of infections like pneumonia.

Diagnosis of ALL includes examining family history, a physical exam, blood counts, and a blood smear. A bone marrow biopsy may also be used to make a concrete diagnosis. Treatments have improved over the years, and about 80% of children diagnosed with ALL are cured. However, the prognosis for older individuals suffering from ALL are less positive. There are many treatment options such as chemotherapy, radiation therapy, biological therapy, and immunotherapy. These may be used alone or in combination with each other. While treatment and survival has improved, early detection is key. It is important to talk to your doctor as soon as possible if you think you or your child may have ALL.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute lymphoblastic leukemia" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute lymphoblastic leukemia" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute lymphoblastic leukemia" returned 2526 free, full-text research articles on human participants. First 3 results:

microRNA-181a enhances cell proliferation in acute lymphoblastic leukemia by targeting EGR1.
 

Author(s): Lorena Verduci, Gianluca Azzalin, Silvia Gioiosa, Claudia Carissimi, Ilaria Laudadio, Valerio Fulci, Giuseppe Macino

Journal: Leuk. Res.. 2015 Apr;39(4):479-85.

 

Acute lymphoblastic leukemia (ALL) is an aggressive cancer that occurs in both children and adults. Starting from an integrated analysis of miRNA/mRNA expression profiles in 20 ALL patients, we identify a negative correlation between miR-181a and EGR1. Coherently, miR-181a over-expression ...

Last Updated: 23 Mar 2015

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[Influence of thymidylate synthase gene polymorphisms on high-dose methotrexate-related toxicities in childhood acute lymphoblastic leukemia].
 

Author(s): Xiu-Juan Zhu, Xiang-Ling He, Yan-Peng Wu, Run-Ying Zou, Wan-Li Li, Hui Zou, Ya-Lan You, Hua Liu, Xin Tian

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Jan;17(1):11-4.

 

To investigate the influence of thymidylate synthase (TS) gene polymorphisms on high-dose methotrexate (HD-MTX)-related toxicities in childhood acute lymphoblastic leukemia (ALL).

Last Updated: 24 Jan 2015

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Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia.
 

Author(s): Yuki Aoki, Takashi Watanabe, Yoriko Saito, Yoko Kuroki, Atsushi Hijikata, Masatoshi Takagi, Daisuke Tomizawa, Mariko Eguchi, Minenori Eguchi-Ishimae, Akiko Kaneko, Rintaro Ono, Kaori Sato, Nahoko Suzuki, Saera Fujiki, Katsuyoshi Koh, Eiichi Ishii, Leonard D Shultz, Osamu Ohara, Shuki Mizutani, Fumihiko Ishikawa

Journal: Blood. 2015 Feb;125(6):967-80.

 

Translocation of the mixed-lineage leukemia (MLL) gene with AF4, AF9, or ENL results in acute leukemia with both lymphoid and myeloid involvement. We characterized leukemia-initiating cells (LICs) in primary infant MLL-rearranged leukemia using a xenotransplantation model. In MLL-AF4 ...

Last Updated: 6 Feb 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute lymphoblastic leukemia" returned 160 free, full-text review articles on human participants. First 3 results:

Treatment of pediatric acute lymphoblastic leukemia.
 

Author(s): Stacy L Cooper, Patrick A Brown

Journal: Pediatr. Clin. North Am.. 2015 Feb;62(1):61-73.

 

Acute lymphoblastic leukemia (ALL) is the most common pediatric oncologic diagnosis, and advances in its treatment have led to progressive improvements in survival. The 4 main components of therapy are remission induction, consolidation, maintenance, and central nervous system-directed ...

Last Updated: 1 Dec 2014

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Development of asparaginase Erwinia chrysanthemi for the treatment of acute lymphoblastic leukemia.
 

Author(s): Wanda L Salzer, Barbara L Asselin, Paul V Plourde, Tim Corn, Stephen P Hunger

Journal: Ann. N. Y. Acad. Sci.. 2014 Nov;1329():81-92.

 

Since it was identified in 1963 as the antileukemic agent in guinea pig serum, L-asparaginase (ASNase) has become an integral component of chemotherapy protocols to treat patients with acute lymphoblastic leukemia (ALL). Escherichia coli and Erwinia chrysanthemi provide the sources ...

Last Updated: 17 Nov 2014

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The biology of relapsed acute lymphoblastic leukemia: opportunities for therapeutic interventions.
 

Author(s): Teena Bhatla, Courtney L Jones, Julia A Meyer, Nicholas A Vitanza, Elizabeth A Raetz, William L Carroll

Journal: J. Pediatr. Hematol. Oncol.. 2014 Aug;36(6):413-8.

 

Although great strides have been made in the improvement of outcome for newly diagnosed pediatric acute lymphoblastic leukemia because of refinements in risk stratification and selective intensification of therapy, the prognosis for relapsed leukemia has lagged behind significantly. ...

Last Updated: 23 Jul 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase I Study of MLN 9708 in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older Adults
 

Status: Recruiting

Condition Summary: Acute Lymphoblastic Leukemia; Lymphoblastic Lymphoma; B-cell Adult Acute Lymphoblastic Leukemia; T-cell Adult Acute Lymphoblastic Leukemia

 

Last Updated: 15 Dec 2014

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Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: Adult B Acute Lymphoblastic Leukemia; Adult T Acute Lymphoblastic Leukemia; Childhood B Acute Lymphoblastic Leukemia; Childhood T Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia

 

Last Updated: 31 Mar 2015

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Risk-Adapted Chemotherapy in Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: B-cell Childhood Acute Lymphoblastic Leukemia; Philadelphia Chromosome Positive Childhood Precursor Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia

 

Last Updated: 1 May 2015

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