Acute Lymphoblastic Leukemia

Common Name(s)

Acute Lymphoblastic Leukemia, Acute lymphoid leukemia

Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL ({18:Trevino et al., 2009}). Genetic Heterogeneity of Acute Lymphoblastic Leukemia A susceptibility locus for acute lymphoblastic leukemia (ALL1) has been mapped to chromosome 10q21. See also ALL2 ({613067}), which has been mapped to chromosome 7p12.2; and ALL3 ({615545}), which is caused by mutation in the PAX5 gene ({167414}) on chromosome 9p.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Lymphoblastic Leukemia" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Lymphoblastic Leukemia" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Lymphoblastic Leukemia" returned 2222 free, full-text research articles on human participants. First 3 results:

Altered resting state functional connectivity in young survivors of acute lymphoblastic leukemia.
 

Author(s): Shelli R Kesler, Meike Gugel, Mika Pritchard-Berman, Clement Lee, Emily Kutner, S M Hadi Hosseini, Gary Dahl, Norman Lacayo

Journal: Pediatr Blood Cancer. 2014 Jul;61(7):1295-9.

 

Chemotherapy treatment for pediatric acute lymphoblastic leukemia (ALL) has been associated with long-term cognitive impairments in some patients. However, the neurobiologic mechanisms underlying these impairments, particularly in young survivors, are not well understood. This study ...

Last Updated: 5 May 2014

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T-lineage acute lymphoblastic leukemia and parvovirus infection in a child with neurofibromastosis-1.
 

Author(s): Pallavi Agarwal, Shano Naseem, Neelam Varma, R K Marwaha

Journal: Indian J Pathol Microbiol. ;56(4):446-8.

 

Neurofibromatosis (NF-1) patients have an increased risk of developing malignancies most commonly rhabdomyosarcomas, optic gliomas, brain tumors and non-lymphocytic leukemias. Acute lymphoblastic leukemia (ALL) has been infrequently reported in association with NF-1. We describe a ...

Last Updated: 20 Jan 2014

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RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.
 

Author(s): Elli Papaemmanuil, Inmaculada Rapado, Yilong Li, Nicola E Potter, David C Wedge, Jose Tubio, Ludmil B Alexandrov, Peter Van Loo, Susanna L Cooke, John Marshall, Inigo Martincorena, Jonathan Hinton, Gunes Gundem, Frederik W van Delft, Serena Nik-Zainal, David R Jones, Manasa Ramakrishna, Ian Titley, Lucy Stebbings, Catherine Leroy, Andrew Menzies, John Gamble, Ben Robinson, Laura Mudie, Keiran Raine, Sarah O'Meara, Jon W Teague, Adam P Butler, Giovanni Cazzaniga, Andrea Biondi, Jan Zuna, Helena Kempski, Markus Muschen, Anthony M Ford, Michael R Stratton, Mel Greaves, Peter J Campbell

Journal: Nat. Genet.. 2014 Feb;46(2):116-25.

 

The ETV6-RUNX1 fusion gene, found in 25% of childhood acute lymphoblastic leukemia (ALL) cases, is acquired in utero but requires additional somatic mutations for overt leukemia. We used exome and low-coverage whole-genome sequencing to characterize secondary events associated with ...

Last Updated: 29 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Lymphoblastic Leukemia" returned 132 free, full-text review articles on human participants. First 3 results:

Oral manifestations resulting from chemotherapy in children with acute lymphoblastic leukemia.
 

Author(s): Everton Freitas de Morais, Jadson Alexandre da Silva Lira, RĂ´mulo Augusto de Paiva Macedo, Klaus Steyllon dos Santos, Cassandra Teixeira Valle Elias, Maria de Lourdes Silva de Arruda Morais

Journal: Braz J Otorhinolaryngol. ;80(1):78-85.

 

Acute lymphocytic leukemia is a type of cancer most common in children and it is characterized by excessive and disordered immature leukocytes in the bone marrow.

Last Updated: 14 Mar 2014

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Vincristine sulfate liposomal injection for acute lymphoblastic leukemia.
 

Author(s): Trisha A Soosay Raj, Amanda M Smith, Andrew S Moore

Journal: Int J Nanomedicine. 2013 ;8():4361-9.

 

Vincristine (VCR) is one of the most extensively used cytotoxic compounds in hemato-oncology. VCR is particularly important for the treatment of acute lymphoblastic leukemia (ALL), a disease that accounts for approximately one-third of all childhood cancer diagnoses. VCR's full therapeutic ...

Last Updated: 15 Nov 2013

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The need for evidence based nutritional guidelines for pediatric acute lymphoblastic leukemia patients: acute and long-term following treatment.
 

Author(s): Joyce L Owens, Sheila J Hanson, Jennifer A McArthur, Theresa A Mikhailov

Journal:

 

High survival rates for pediatric leukemia are very promising. With regard to treatment, children tend to be able to withstand a more aggressive treatment protocol than adults. The differences in both treatment modalities and outcomes between children and adults make extrapolation ...

Last Updated: 1 Nov 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma
 

Status: Recruiting

Condition Summary: Contiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Stage II Adult T-cell Leukemia/Lymphoma; Stage II Childhood Lymphoblastic Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Childhood Lymphoblastic Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Childhood Lymphoblastic Lymphoma; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Childhood Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia

 

Last Updated: 9 Jul 2014

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Bortezomib and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: B-cell Adult Acute Lymphoblastic Leukemia; Ph Positive Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; T-cell Adult Acute Lymphoblastic Leukemia

 

Last Updated: 13 Jul 2014

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Risk-Adapted Chemotherapy in Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: B-cell Childhood Acute Lymphoblastic Leukemia; Philadelphia Chromosome Positive Childhood Precursor Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia

 

Last Updated: 17 Feb 2014

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