Acute Lymphoblastic Leukemia

Common Name(s)

Acute Lymphoblastic Leukemia, Acute lymphoid leukemia

Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL ({19:Trevino et al., 2009}). Genetic Heterogeneity of Acute Lymphoblastic Leukemia A susceptibility locus for acute lymphoblastic leukemia (ALL1) has been mapped to chromosome 10q21. See also ALL2 ({613067}), which has been mapped to chromosome 7p12.2; and ALL3 ({615545}), which is caused by mutation in the PAX5 gene ({167414}) on chromosome 9p.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Lymphoblastic Leukemia" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Lymphoblastic Leukemia" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Lymphoblastic Leukemia" returned 2357 free, full-text research articles on human participants. First 3 results:

[Correlations between 6-mercaptopurine treatment-related adverse reactions in children with acute lymphoblastic leukemia and polymorphisms of thiopurine methyltransferase gene].
 

Author(s): Cai Xie, Li-Jie Yue, Hui Ding, Yan-Fei Ren, Chun-Lan Yang, Miao-Miao Zheng

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 May;16(5):499-503.

 

To explore 6-mercaptopurine (6-MP) treatment-related adverse reactions in children with acute lymphoblastic leukemia (ALL), and to assess the association between the polymorphisms of thiopurine methyltransferase (TPMT) gene and these 6-MP related toxicities.

Last Updated: 26 May 2014

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[A comparison of minimal residual disease in children with acute lymphoblastic leukemia of different genetic abnormalities].
 

Author(s): Shan-Ya-Mei Huang, Yue-Ping Jia, Gui-Lan Liu, Le-Ping Zhang, Ai-Dong Lu, Bin Wang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 May;16(5):494-8.

 

To study the changes of minimal residual disease (MRD) in children with B cell acute lymphoblastic leukemia (B-ALL) of different genetic abnormalities.

Last Updated: 26 May 2014

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Phase II trial of hyper CVAD and dasatinib in patients with relapsed Philadelphia chromosome positive acute lymphoblastic leukemia or blast phase chronic myeloid leukemia.
 

Author(s): Ohad Benjamini, Theresa Liu Dumlao, Hagop Kantarjian, Susan O'Brien, Guillermo Garcia-Manero, Stefan Faderl, Jeffrey Jorgensen, Rajyalakshmi Luthra, Rebecca Garris, Deborah Thomas, Partow Kebriaei, Richard Champlin, Elias Jabbour, Jan Burger, Jorge Cortes, Farhad Ravandi

Journal: Am. J. Hematol.. 2014 Mar;89(3):282-7.

 

Dasatinib is a second generation tyrosine kinase inhibitor, with activity in imatinib resistant Ph-positive ALL.We have treated 34 patients with relapsed Philadelphia chromosome positive acute lymphoblastic leukemia(ALL) (n519) or lymphoid blast phase of chronic myelogenous leukemia ...

Last Updated: 21 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Lymphoblastic Leukemia" returned 142 free, full-text review articles on human participants. First 3 results:

Oral manifestations resulting from chemotherapy in children with acute lymphoblastic leukemia.
 

Author(s): Everton Freitas de Morais, Jadson Alexandre da Silva Lira, RĂ´mulo Augusto de Paiva Macedo, Klaus Steyllon dos Santos, Cassandra Teixeira Valle Elias, Maria de Lourdes Silva de Arruda Morais

Journal: Braz J Otorhinolaryngol. ;80(1):78-85.

 

Acute lymphocytic leukemia is a type of cancer most common in children and it is characterized by excessive and disordered immature leukocytes in the bone marrow.

Last Updated: 14 Mar 2014

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Genomic characterization of childhood acute lymphoblastic leukemia.
 

Author(s): Charles G Mullighan

Journal: Semin. Hematol.. 2013 Oct;50(4):314-24.

 

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and a leading case of childhood cancer death. The last decade has witnessed a transformation in our understanding of the genetic basis of ALL due to detailed integrative genomic profiling of large cohorts of ...

Last Updated: 19 Nov 2013

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Vincristine sulfate liposomal injection for acute lymphoblastic leukemia.
 

Author(s): Trisha A Soosay Raj, Amanda M Smith, Andrew S Moore

Journal: Int J Nanomedicine. 2013 ;8():4361-9.

 

Vincristine (VCR) is one of the most extensively used cytotoxic compounds in hemato-oncology. VCR is particularly important for the treatment of acute lymphoblastic leukemia (ALL), a disease that accounts for approximately one-third of all childhood cancer diagnoses. VCR's full therapeutic ...

Last Updated: 15 Nov 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase I Study of MLN 9708 in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older Adults
 

Status: Not yet recruiting

Condition Summary: Acute Lymphoblastic Leukemia; Lymphoblastic Lymphoma; B-cell Adult Acute Lymphoblastic Leukemia; T-cell Adult Acute Lymphoblastic Leukemia

 

Last Updated: 27 Aug 2014

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Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: B-cell Adult Acute Lymphoblastic Leukemia; B-cell Childhood Acute Lymphoblastic Leukemia; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Childhood Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia

 

Last Updated: 9 Sep 2014

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Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: Childhood Acute Lymphoblastic Leukemia; Philadelphia Chromosome, Ph^1^, Absent; B-cell Childhood Acute Lymphoblastic Leukemia

 

Last Updated: 20 Nov 2013

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