Acute Intermittent Porphyria

Common Name(s)

Acute Intermittent Porphyria

Acute intermittent porphyria (AIP) is one of the liver (hepatic) porphyrias. AIP is caused by low levels of porphobilinogen deaminase (PGBD), an enzyme also often called hydroxymethylbilane synthase. The low levels of PGBD are generally not sufficient to cause symptoms; however, activating factors such as hormones, drugs, and dietary changes may trigger symptoms. Although most individuals with AIP never develop symptoms, symptomatic individuals typically present with abdominal pain. Treatment is dependent on the symptoms.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Intermittent Porphyria" for support, advocacy or research.

American Porphyria Foundation

The mission of the American Porphyria Foundation is to enhance awareness and education about the Porphyrias and to aid in advancing treatment of this group of disorders.

Last Updated: 2 Dec 2009

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Intermittent Porphyria" for support, advocacy or research.

American Porphyria Foundation

The mission of the American Porphyria Foundation is to enhance awareness and education about the Porphyrias and to aid in advancing treatment of this group of disorders.

http://www.porphyriafoundation.com

Last Updated: 2 Dec 2009

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Intermittent Porphyria" returned 131 free, full-text research articles on human participants. First 3 results:

Biochemical and hematological analysis in acute intermittent porphyria (AIP): a case report.
 

Author(s): Anna R R Dos Santos, Rafaela R De Albuquerque, Maria J R Doriqui, Graciomar C Costa, Ana Paula S A Dos Santos

Journal: An. Acad. Bras. Cienc.. 2013 Sep;85(3):1207-14.

 

Acute intermittent porphyria is the most common acute porphyria caused by a decrease in hepatic porphobilinogen deaminase activity, resulting in an accumulation of delta-aminolevulinic acid and porphobilinogen. This disease shows nonspecific signs and symptoms that can be confused ...

Last Updated: 26 Sep 2013

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Challenges in the diagnosis and treatment of a case of acute intermittent porphyria in India.
 

Author(s): R V Dosi, A P Ambaliya, R D Patell, N N Sonune

Journal: J Postgrad Med. ;59(3):241-2.

 

Last Updated: 13 Sep 2013

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Conformational stability and activity analysis of two hydroxymethylbilane synthase mutants, K132N and V215E, with different phenotypic association with acute intermittent porphyria.
 

Author(s): Helene J Bustad, Marta Vorland, Eva Rønneseth, Sverre Sandberg, Aurora Martinez, Karen Toska

Journal:

 

The autosomal dominantly inherited disease AIP (acute intermittent porphyria) is caused by mutations in HMBS [hydroxymethylbilane synthase; also known as PBG (porphobilinogen) deaminase], the third enzyme in the haem biosynthesis pathway. Enzyme-intermediates with increasing number ...

Last Updated: 5 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Intermittent Porphyria" returned 3 free, full-text review articles on human participants. First 3 results:

[Acute intermittent porphyria presenting as spontaneous hemothorax].
 

Author(s): Juliana Buitrago, Sandra Viviana Santa

Journal: Biomedica. 2009 Sep;29(3):339-47.

 

The porphyrias are inherited disorders of the heme biosynthetic pathway. They are relatively rare and often misdiagnosed; however, acute episodes can be curtailed by early administration of heme arginate. Acute intermittent porphyria is the commonest of acute forms of porphyria. Here, ...

Last Updated: 3 May 2010

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May 2006 update in porphobilinogen deaminase gene polymorphisms and mutations causing acute intermittent porphyria: comparison with the situation in Slavic population.
 

Author(s): M Hrdinka, H Puy, P Martasek

Journal: Physiol Res. 2006 ;55 Suppl 2():S119-36.

 

Acute intermittent porphyria (AIP) is an autosomal dominant disorder of heme biosynthesis caused by molecular defects in the porphobilinogen deaminase (PBGD) gene. This paper reviews published mutations, their types, and polymorphisms within the PBGD gene. To date, 301 different mutations ...

Last Updated: 14 Feb 2007

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The three-dimensional structures of mutants of porphobilinogen deaminase: toward an understanding of the structural basis of acute intermittent porphyria.
 

Author(s): P D Brownlie, R Lambert, G V Louie, P M Jordan, T L Blundell, M J Warren, J B Cooper, S P Wood

Journal: Protein Sci.. 1994 Oct;3(10):1644-50.

 

Mutations in the human gene for the enzyme porphobilinogen deaminase give rise to an inherited disease of heme biosynthesis, acute intermittent porphyria. Knowledge of the 3-dimensional structure of human porphobilinogen deaminase, based on the structure of the bacterial enzyme, allows ...

Last Updated: 13 Mar 1995

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Dental Health, Diet, Inflammation and Biomarkers in Patients With Acute Intermittent Porphyria(AIP)
 

Status: Not yet recruiting

Condition Summary: Acute Intermittent Porphyria

 

Last Updated: 8 Jun 2012

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Clinical Diagnosis of Acute Porphyria
 

Status: Recruiting

Condition Summary: Hereditary Coproporphyria (HCP); Acute Intermittent Porphyria (AIP); Variegate Porphyria (VP)

 

Last Updated: 23 Sep 2013

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Controlled Trial of Panhematin in Treatment of Acute Attacks of Porphyria
 

Status: Recruiting

Condition Summary: Acute Porphyrias

 

Last Updated: 30 Jun 2014

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