Angioedema, hereditary, type II

Common Name(s)

Angioedema, hereditary, type II

Hereditary angioedema (HAE) is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. There are 2 classic types of the disorder. In type I, representing 85% of patients, serum levels of C1NH are less than 35% of normal ({10:Cicardi and Agostoni, 1996}; {8:Bowen et al., 2001}). In type II, the levels are normal or elevated, but the protein is nonfunctional. The 2 types are clinically indistinguishable. See {300145} for a discussion of angioedema induced by ACE inhibitors. {78:Zuraw (2008)} provided a detailed review of the clinical features, management, and pathogenesis of hereditary angioedema.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Angioedema, hereditary, type II" for support, advocacy or research.

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Scientific Literature

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study to Assess the Tolerability and Safety of Ecallantide in Children and Adolescents With Hereditary Angioedema
 

Status: Not yet recruiting

Condition Summary: Hereditary Angioedema Types I and II

 

Last Updated: 15 Apr 2013

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Last Updated: 11 May 2014

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